Immunogenetics: A Molecular and Clinical Overview

Immunogenetics: A Molecular and Clinical Overview

Clinical Applications of Immunogenetics

1st Edition - March 24, 2022

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  • Editors: Muneeb Rehman, Azher Arafah, Md. Niamat Ali, Shafat Ali
  • eBook ISBN: 9780323902519
  • Paperback ISBN: 9780323902502

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Clinical Applications of Immunogenetics: Immunogenetics: A Molecular and Clinical Overview, Volume II provides readers with an exclusive, updated overview of scientific knowledge, achievements and findings in the field of immunogenetics. In thirteen chapters, the book gives insights in new advancements and approaches in viral and autoimmune diseases. Specific chapters are dedicated to immunogenetic mechanisms in the treatment of immune disorders, cancer, neurological and neurodegenerative disorders. In addition, other chapters cover immunogenomics in precision medicine, clinical medicine and transplantation. Finally, a special chapter, COVID-19: A novel challenge to human immune-genetic machinery, updates on thoughts surrounding the pandemic.

Key Features

  • Contains exclusive information about global research on immunogenetics
  • Provides a solid foundation to researchers wanting to work on immunogenetics and their application in different autoimmune, viral and infectious diseases
  • Delivers information in a meticulous, attractive manner using pictures, illustrations and tables
  • Gives insights into immunogenetics and its utility in therapeutics


Researchers and Scientist, Students, Academicians, immunologists, Immuno-genetics, Pharmaco-genetics, specialists in infectious diseases, connective tissue diseases, viral and autoimmune diseases, as well as to medical scientists in immunology and molecular biology. Researchers in universities, colleges, R and D of industries, medical practitioner including the immunologists, genetics, dieticians, scientist in pharmacology, cytology, genetics academicians, college students and teachers

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • List of contributors
  • About the editors
  • Preface
  • Chapter 1. Immunogenetics and its utility in therapeutics
  • Abstract
  • Introduction
  • Immunogenetics
  • Classification of major histocompatibility complex
  • Distribution of major histocompatibility complex
  • Importance of major histocompatibility complex
  • Classification of human leukocyte antigen complex
  • Importance of human leukocyte antigen allele system
  • Methods for detecting antigens and alleles
  • Human leukocyte antigen system nomenclature
  • Immunogenetics and inherited multifactorial diseases and disorders
  • Immunogenetics and spectrum of immune disorders
  • Autoimmune diseases
  • Neurological diseases
  • Infectious diseases
  • Bacterial infection
  • Parasitic infections
  • Immunosenescence
  • Immunogenetics and vaccine design
  • Immunogenetics and response to vaccination
  • Immunogenetics, prevention and its utility in the treatment
  • Challenges in vaccine development
  • Conclusion
  • References
  • Chapter 2. Immunogenetics in the diagnosis of clinical disorders
  • Abstract
  • Introduction
  • Human leukocyte antigen class I and class II
  • Association of human leukocyte antigen region with disease
  • Limitations
  • Conclusion
  • References
  • Chapter 3. Immunogenetic markers as prognostic tools for the management of various human diseases
  • Abstract
  • Introduction
  • Biologic markers
  • Cytokines
  • Pro-inflammatory cytokines
  • Tumor necrosis factor
  • Interferon-γ
  • Chemokines
  • Immunogenetic markers in auto-immune disorders
  • Systemic lupus erythematous
  • Integrin alpha M, FCGR2A, vitamin D receptor, interleukin-6 polymorphism
  • Immunogenetic markers of multiple sclerosis
  • Type 1 diabetes mellitus
  • Major histocompatibility complex markers
  • Nonmajor histocompatibility complex markers
  • Myasthenia gravis
  • Human leukocyte antigen and myasthenia gravis
  • Immunoglobulins and myasthenia gravis
  • Epigenetic processes and myasthenia gravis
  • Conclusion
  • References
  • Chapter 4. Immunogenetic disorders: treatment with phytomedicines
  • Abstract
  • Introduction
  • Severe combined immunodeficiency
  • Treatment of immunogenetic diseases by phytocompounds
  • Echinacea purpurea
  • Lithospermum erythrorhizon
  • Dioscorea family
  • Phytochemicals/photocompounds: regulators of immunity
  • Alkaloids
  • Terpenoids
  • Polysaccharides
  • Conclusion
  • References
  • Chapter 5. Understanding the immunogenetics of human viral diseases
  • Abstract
  • Introduction
  • Human leukocyte antigen
  • Human leukocyte antigen and infectious diseases
  • Viral infections
  • Human leukocyte antigen and acquired immunodeficiency syndrome
  • Dengue viruses
  • Dengue
  • Clinical manifestations of dengue
  • Dengue fever
  • Dengue hemorrhagic fever
  • Dengue shock syndrome
  • Dengue and human leukocyte antigen
  • Hantavirus
  • Hantavirus pathogenesis and host immunity
  • Hantavirus and human leukocyte antigen
  • COVID-19
  • COVID-19 and human leukocyte antigen
  • Signaling pathways
  • Toll like receptor pathway
  • Nuclear factor kappa beta pathway
  • JAK-STAT pathway
  • Protein kinase-C-mediated pathway
  • Ras-MAP kinase pathway
  • PI3K-AKT pathway
  • Vaccinomics and adversomics: immunogenetics and vaccination response
  • Conclusion
  • References
  • Chapter 6. MicroRNAs as potential immunotherapeutic modulators in cancer
  • Abstract
  • Introduction
  • microRNAs biogenesis
  • Gene expression regulation by microRNAs
  • microRNAs in cancer immunotherapy
  • microRNAs as immunotherapeutic targets or agents
  • Conclusion
  • References
  • Further reading
  • Chapter 7. Immunogenetic perspective of inflammatory disorders
  • Abstract
  • Introduction
  • Mediators of inflammation
  • Pathways of inflammatory response
  • Nuclear factor kappa-B pathway
  • MAPK pathway
  • JAK–STAT pathway
  • NETosis, inflammation, and autoimmunity: a triangular relationship
  • Immunogenetics of inflammatory disorders
  • Conclusion
  • References
  • Chapter 8. Immunogenetic mechanism driving neurological and neurodegenerative disorders
  • Abstract
  • Introduction
  • Major histocompatibility complex region and neurological disease
  • Various neurological and neurodegenerative disorders
  • Innate immune response and neurodegeneration
  • Adaptive immune response and neurodegeneration
  • References
  • Chapter 9. Human leukocyte antigen-typing: a significant immunogenetic application in clinical medicine
  • Abstract
  • Introduction
  • Classification of human leukocyte antigen molecules
  • Human leukocyte antigen-typing
  • Clinical applications of human leukocyte antigen typing
  • Conclusion
  • References
  • Chapter 10. Immunogenomics: a potential approach for precision medicine
  • Abstract
  • Introduction to immunogenomics
  • Available immunogenomic technologies in immunotherapy-based personalized medicine
  • Biomarker identification from immunogenomics
  • Neoantigens
  • High-throughput T cell receptor sequencing
  • T cell receptor and B cell receptor sequencing with next-generation sequencers
  • Changes in T cell during immunotherapy
  • Immunotherapy by neoantigen-specific T cell receptor
  • Assessment of immune biomarkers by genomic tools
  • Discovery of immunotherapy biomarkers guided by immunogenomics
  • Future directions
  • References
  • Chapter 11. Rheumatoid arthritis: immunogenetic factors and immune therapies
  • Abstract
  • Introduction
  • Conclusion
  • Acknowledgment
  • Funding
  • Conflict of interest
  • Author contributions
  • References
  • Chapter 12. Covid-19: a novel challenge to human immune genetic machinery
  • Abstract
  • Introduction
  • Patient presentation
  • Receptor
  • Structure of Corona virus
  • Fatality
  • Role of comorbid illnesses in Covid-19
  • Treatment modalities
  • Emergence of vaccines
  • Molecular aspects of corona virus
  • Exosomes
  • Immune cell development and importance of micro RNAs
  • Other roles of micro RNA
  • Immune response
  • Hypersensitivity reactions
  • Cytokine storm
  • Cytokine release syndrome
  • Conclusion
  • References
  • Further reading
  • Chapter 13. Immunogenetic mechanisms in the treatment of cancer
  • Abstract
  • Introduction of cancer
  • Immune regulation of cancer
  • Immune evasion in cancer: therapeutic strategies
  • Future perspectives
  • References
  • Chapter 14. Transplantation immunogenetics
  • Abstract
  • Abbreviations
  • Introduction
  • Innate and adaptive immunities
  • Transplantation antigens
  • The major histocompatibility complex
  • The impact of non-human leukocyte antigens immunogenetics on hematopoietic stem cell transplantation
  • Major histocompatibility complex class I-related chain genes and HSCT
  • Minor histocompatibility antigens and HSCT
  • The allogeneic immune response
  • Clinical applications of transplantation immunogenetics
  • Conclusion
  • References
  • Chapter 15. Immunognetics: a tool for the identification of novel therapeutic targets in immune disorders
  • Abstract
  • Introduction
  • The genetic architecture of human major histocompatibility complex
  • Constraints in mapping major histocompatibility complex genes
  • The international immunognetics information system
  • Immunognetics and inherited risk of multifactorial diseases
  • Immunognetics and the spectrum of immune disorders
  • Autoimmune diseases
  • Rheumatoid arthritis
  • Autoimmune thyroid diseases
  • Primary biliary cirrhosis
  • Type 1 diabetes mellitus
  • Systemic lupus erythematosus
  • Systemic sclerosis
  • Multiple sclerosis
  • Infectious diseases
  • Hepatitis B virus and hepatitis C virus infection
  • Tuberculosis
  • Immunognetics and immunosenescence
  • Immunognetics of atopic diseases
  • Vaccinomics and adversomics: immunognetics and response to vaccination
  • Immunoassay techniques in immunognetics diseases
  • Multiplex Western blot
  • Capillary electrophoresis and capillary Western blotting
  • Microfluidic Western blotting
  • Dot blot
  • Far-Western blotting
  • Protein microarray
  • Luminex xMAP array
  • Conclusion
  • References
  • Chapter 16. Therapeutic approaches of immunogenetic molecules in inflammatory bowel disease management
  • Abstract
  • Introduction
  • Targeting proinflammatory mediators’ pathways in inflammatory bowel disease theuraptic management
  • Molecular biological drugs
  • Conclusion
  • References
  • Further reading
  • Index

Product details

  • No. of pages: 426
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: March 24, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323902519
  • Paperback ISBN: 9780323902502

About the Editors

Muneeb Rehman

Muneeb U Rehman (Ph.D.) is a Faculty member at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Toxicology (specialization in cancer biology and natural product research) from Jamia Hamdard, New Delhi, India Dr. Rehman has more than 10 years of research and teaching experience in the field of toxicology, biochemistry, cancer biology, natural product research and pharmacogenomics. He is the recipient of several national and international fellowships and awards. He has published more than 100 research papers in peer-reviewed, international journals, and has 7 edited books and 39 book chapters to his name. Dr. Rehman is an on the editorial boards and is a reviewer of several high-impact, international scientific journals. He is also a life member of various international societies and organizations. Currently, Dr. Rehman is engaged in studying the molecular mechanisms of cancer prevention by natural products and the role of pharmacogenomics and toxicogenomics in evaluating the effectiveness and safety of drugs.

Affiliations and Expertise

Faculty Member, King Saud University, Riyadh, Saudi Arabia

Azher Arafah

Affiliations and Expertise

Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Md. Niamat Ali

Md. Niamat Ali (M. Phil, Ph.D.) is Director and Faculty member at Centre of Research for Development, University of Kashmir, Srinagar, India. After completing his doctorate in Zoology (Specialization in Cytogenetics and Molecular Biology), Aligarh Muslim University, Aligarh, India in 1994. He worked as Research Associate and Pool Officer (CSIR, New Delhi) at the Aligarh Muslim University, Aligarh, India till 2002. Later He joined Department of Zoology, University of Kashmir, Srinagar, India and worked there till 2013. Prof. Ali has more than 29 years of research experience and 25 years of teaching experience in Cytogenetics and Molecular Biology, Toxicogenomics, Human Genomics and Proteomics, Stem Cell Biology, Regenerative Medicine, Radiation Biology and Gene Therapy, Cell and Tissue Culture Technology and Ageing Biology, PCR and DNA Fingerprinting Technology, FISH Technology and Comet Assay and Biostatistics. He is the recipient of several fellowships and awards at both national and international levels. He is a Life Member of Indian Science Congress Association and Environmental Mutagen Society of India, India. Prof. Ali is handling many projects of national and international importance. He also has to his credit 65 research publications in peer-reviewed international journals and multiple book chapters in edited volumes with international publishers. Prof. Ali is on editorial board panel and reviewer of several high-impact international scientific journals from Springer, Elsevier and John Wiley. He also has served as Executive Editor of Journal/ Editor Souvenir and Abstract Book for Seminar and Conference/ Workshop Guide Books. Currently, Prof. Ali is involved in studying vermin-technology, eco-toxicology, fish toxicology, DNA bar-coding, cancer biology, congenital human diseases, immunogenetic mechanisms of Recurrent Pregnancy loss etc.

Affiliations and Expertise

Cytogenetics and Molecular Biology Laboratory, Centre of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India

Shafat Ali

Shafat Ali pursued his BSc. from University of Kashmir and Masters in Zoology from Barkatullah Vishwavidyalaya, India. Currently he is engaged in research work for last 5 years at Cytogenetics and Molecular Biology Laboratory, Centre of Research for Development, University of Kashmir, Department of Biochemistry, Government Medical College, Srinagar, Jammu and Kashmir, and ICMR funded Multidisciplinary Research Unit, Government Medical College, Srinagar, Jammu and Kashmir, India, with specialization in the field of reproductive immunogenetics, cytokine biology, gynaecology and obstetrics, molecular biology, cancer biology and cytogenetics. He has 5 years of research experience and 5 years of teaching experience. He is the recipient of several awards and fellowships at both national and international levels. He has more than 20 book chapters, several edited books and multiple peer-reviewed, international research publications to his credit. Mr. Ali is also the reviewer of many reputed international journals. Presently, Mr. Ali is involved in studying immunogenetic mechanisms involved in recurrent pregnancy loss.

Affiliations and Expertise

Cytogenetics and Molecular Biology Laboratory Centre of Research for Development, University of Kashmir, Jammu and Kashmir, India

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