Immunogenetics: A Molecular and Clinical Overview

Immunogenetics: A Molecular and Clinical Overview

A Molecular Approach to Immunogenetics

1st Edition - November 26, 2021

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  • Editors: Muneeb Rehman, Azher Arafah, Md. Niamat Ali, Shafat Ali
  • Paperback ISBN: 9780323900539
  • eBook ISBN: 9780323903356

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A Molecular Approach to Immunogenetics, Immunogenetics: A Molecular and Clinical Overview, Volume One provides readers with an exclusive, updated overview on the scientific knowledge, achievements and findings in the field of immunogenetics. The book presents readily available, updated information on the molecular and clinical aspects of immunogenetics, from origin and development to clinical applications and future prospects. The breadth of information goes from basics to developments, clinical applications and future prospects. The book's most attractive attribute is its academic and clinical amalgamation that covers both the theoretical and practical aspects of immunogenetics. An additional feature of the book is a special chapter on viral genetics that covers COVID-19. Above all, the book contains chapters that discuss immunogenetics in relation to pharmaco-genomics and immune-toxicology.

Key Features

  • Contains exclusive information about research on immunogenetics from around the globe
  • Includes minute and recent details that will be the prerequisite requirement for any researcher who wants to work on immunogenetics and its applications
  • Comes fully-equipped with pictures, illustrations and tables that deliver information in a meticulous manner


Researchers and Scientist, Students, Academicians, Immuno-genetists, Pharmaco-genetists, specialists in infectious diseases, endocrinology, connective tissue diseases, and neurology, as well as to medical scientists in immunology and molecular biology. Researches in universities, colleges, R and D of industries, medical practioner including the genetists, dieticians, scientist in pharmacology, cytology, genetics academicians, college students and teachers

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • List of contributors
  • Preface
  • Chapter 1. Origin and history of immunogenetics
  • Abstract
  • 1.1 Introduction
  • 1.2 Immunogenetics and discovery of blood groups
  • 1.3 Origin of immunogenetics
  • 1.4 Major histocompatibility complex
  • 1.5 MHC class I
  • 1.6 MHC class II
  • 1.7 MHC class III
  • 1.8 Immunogenetics and the spectrum of immune disorders
  • 1.9 Autoimmune diseases
  • 1.10 Neurological diseases
  • 1.11 Infectious diseases
  • 1.12 Atopic diseases
  • 1.13 Conclusion
  • References
  • Chapter 2. Immunogenetics: the developmental course
  • Abstract
  • 2.1 Introduction
  • 2.2 Genetic defects associated with immune deficiency
  • 2.3 B cell deficiency
  • 2.4 T cell deficiency
  • 2.5 Regulatory T cell deficiency
  • 2.6 Phagocyte deficiency
  • 2.7 Defects in cytokine signaling
  • 2.8 Origin of immunogenetics
  • 2.9 History of immunogenetics
  • 2.10 Discovery of the major histocompatibility gene complex
  • 2.11 Genetic organization of the human leukocyte antigen system
  • 2.12 The most polymorphic human genomic region
  • 2.13 Role of human leukocyte antigen in creating the first physical and genetic map of the human genome
  • 2.14 Conclusion
  • References
  • Chapter 3. Basics of immunogenetics: application and future perspectives
  • Abstract
  • 3.1 Introduction
  • 3.2 Application of genomic procedures to major immunodeficiency syndromes
  • 3.3 Biogenetic variation, functional genomics, and the immune system
  • 3.4 Histocompatibility complex region of humans and neurological disease
  • 3.5 Killer-immunoglobulin-like receptor network is a novel range of neural infection in genetics of immune system
  • 3.6 Human leukocyte antigen antibody screening by ELISA
  • 3.7 Flow cytometry and luminex techniques for the screening of human leukocyte antigen antibody
  • 3.8 Human leukocyte antigen antibody identification
  • 3.9 Polymerase chain reaction sequence-based typing
  • 3.10 Polymerase chain reaction-sequence specific primers or (PCR-SSP)
  • 3.11 Future perspectives of immunogenetics
  • References
  • Chapter 4. Immunogenetics: a tool for anthropological studies
  • Abstract
  • 4.1 Introduction
  • 4.2 Human genetic diversity
  • 4.3 HLA and KIR polymorphism
  • 4.4 Gene frequency analysis
  • 4.5 To Test disease associations
  • 4.6 Conclusion
  • References
  • Chapter 5. Immunogenetic surveillance to histocompatibility
  • Abstract
  • 5.1 Introduction
  • 5.2 Major Histocompatibility Complex genomics and human disease
  • 5.3 The Major Histocompatibility Complex locus and genetic susceptibility to autoimmune and infectious diseases
  • 5.4 Role of Major Histocompatibility Complex variants in human diseases
  • 5.5 Genetic restraint of the immune reaction
  • 5.6 Major Histocompatibility Complex class I chain-related molecule (MICA) antibodies in transplantation
  • 5.7 Immune response to MICA
  • 5.8 Conclusion and future perspectives
  • References
  • Chapter 6. Gestational immunogenetics: an overview
  • Abstract
  • 6.1 Introduction
  • 6.2 Placenta as an anatomical barrier
  • 6.3 Placental human leucocyte antigen molecules
  • 6.4 Immune responses at the fetomaternal interface
  • 6.5 Conclusion
  • References
  • Chapter 7. Gene polymorphisms and their role in autoimmunity
  • Abstract
  • 7.1 Introduction
  • 7.2 Autoimmunity and autoimmune genes
  • 7.3 Toll like receptors polymorphism and effects on autoimmunity
  • 7.4 Vitamin D receptor polymorphism and their role in autoimmunity
  • 7.5 Major histocompatibility complex gene polymorphism and autoimmunity
  • 7.6 Genetic polymorphism and autoimmune disorders
  • 7.7 Immunogenetics and immune therapy
  • 7.8 Conclusion
  • References
  • Chapter 8. Role of immunogenetics polymorphisms in infectious diseases
  • Abstract
  • 8.1 Introduction
  • 8.2 The major histocompatibility complex/human leukocyte antigen system: general structure and gene organization
  • 8.3 Classification of major histocompatibility complex genes
  • 8.4 Human leukocyte antigen system and the infectious diseases (function and association)
  • 8.5 Human leukocyte antigen system and the human immunodeficiency virus
  • 8.6 Human leukocyte antigen system and tuberculosis
  • 8.7 Human leukocyte antigen system and malaria
  • 8.8 Conclusion
  • Acknowledgments
  • Disclosure/conflict of interest
  • Author’s contributions
  • References
  • Chapter 9. MicroRNAs and their role in immunogenetic-dysregulation
  • Abstract
  • 9.1 Introduction
  • 9.2 Genetic bases of immune response
  • 9.3 miRNA regulating immune response
  • 9.4 miRNA and immune tolerance
  • 9.5 miRNA and immune checkpoint proteins
  • 9.6 Conclusion
  • References
  • Further reading
  • Chapter 10. Immunogenetic causes of infertility
  • Abstract
  • 10.1 Introduction
  • 10.2 Immunogenetic factors as a cause of infertility
  • 10.3 Conclusion
  • References
  • Chapter 11. Immunopharmacogenomics: clinical applications, challenges, and future prospects
  • Abstract
  • 11.1 Introduction
  • 11.2 Immunopharmacogenomics in cancer therapy
  • 11.3 Immunopharmacogenomics in autoimmunity
  • 11.4 Immunopharmacogenomics in food allergy
  • 11.5 Immunopharmacogenomics and adverse drug reactions
  • 11.6 Organ transplant rejection and immunopharmacogenomics
  • 11.7 Challenges of immunopharmacogenomics
  • 11.8 Future direction
  • 11.9 Conclusion
  • References
  • Chapter 12. Immunopharmacology of Alzheimer’s disease
  • Abstract
  • 12.1 Introduction
  • 12.2 Innate immunity and Alzheimer’s disease
  • 12.3 Alzheimer’s disease and interferons
  • 12.4 Alzheimer’s disease and glial cells
  • 12.5 Alzheimer’s dementia and microglia
  • 12.6 Astrocytes and Alzheimer’s disease
  • 12.7 Alzheimer’s disease and oligodendrocytes
  • 12.8 Alzheimer’s dementia and glia barriers
  • 12.9 Alzheimer’s disease and current immune-related therapies
  • 12.10 Conclusion
  • References
  • Chapter 13. miRNAs: the genetic regulators of immunity
  • Abstract
  • 13.1 Introduction
  • 13.2 MicroRNA biogenesis
  • 13.3 Immuno-miRNAs: vital immune regulators
  • 13.4 miRNA-mediated regulation of T cell differentiation and function
  • 13.5 Conclusion
  • References
  • Further reading
  • Chapter 14. Immunopharmacogenomics: a hope in the treatment of carcinoma
  • Abstract
  • 14.1 Introduction
  • 14.2 Cancer immunogenomics
  • 14.3 Cancer genomic biomarkers
  • 14.4 Cancer antigens and neoantigens
  • 14.5 Cancer immunotherapy
  • 14.6 Personalized cancer therapies
  • 14.7 Conclusion
  • References
  • Chapter 15. Immunopharmaco-genomics: future of clinical medicine
  • Abstract
  • 15.1 Introduction
  • 15.2 Adverse drug reactions
  • 15.3 Genomics approaches to illuminate the complexity of drug response
  • 15.4 Challenges for genetic association studies of IM-ADRs
  • 15.5 Approaches to determine IM-ADR mechanisms
  • 15.6 Role of immunopharmacogenomics in preventing IM-ADRs
  • 15.7 Complexities of the human immune system
  • 15.8 Applications of T cell receptors/B cell receptors sequencing
  • 15.9 Future perspectives of immunopharmacogenomics
  • References
  • Index

Product details

  • No. of pages: 410
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: November 26, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780323900539
  • eBook ISBN: 9780323903356

About the Editors

Muneeb Rehman

Muneeb U Rehman (Ph.D.) is a Faculty member at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Toxicology (specialization in cancer biology and natural product research) from Jamia Hamdard, New Delhi, India Dr. Rehman has more than 10 years of research and teaching experience in the field of toxicology, biochemistry, cancer biology, natural product research and pharmacogenomics. He is the recipient of several national and international fellowships and awards. He has published more than 100 research papers in peer-reviewed, international journals, and has 7 edited books and 39 book chapters to his name. Currently, Dr. Rehman is engaged in studying the molecular mechanisms of cancer prevention by natural products and the role of pharmacogenomics and toxicogenomics in evaluating the effectiveness and safety of drugs

Affiliations and Expertise

Faculty Member, Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Azher Arafah

Affiliations and Expertise

Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Md. Niamat Ali

Md. Niamat Ali (M. Phil, Ph.D.) is Director and Faculty member at Centre of Research for Development, University of Kashmir, Srinagar, India. After completing his doctorate in Zoology (Specialization in Cytogenetics and Molecular Biology), Aligarh Muslim University, Aligarh, India in 1994. He worked as Research Associate and Pool Officer (CSIR, New Delhi) at the Aligarh Muslim University, Aligarh, India till 2002. Later He joined Department of Zoology, University of Kashmir, Srinagar, India and worked there till 2013. Prof. Ali has more than 29 years of research experience and 25 years of teaching experience in Cytogenetics and Molecular Biology, Toxicogenomics, Human Genomics and Proteomics, Stem Cell Biology, Regenerative Medicine, Radiation Biology and Gene Therapy, Cell and Tissue Culture Technology and Ageing Biology, PCR and DNA Fingerprinting Technology, FISH Technology and Comet Assay and Biostatistics. He is the recipient of several fellowships and awards at both national and international levels. He is a Life Member of Indian Science Congress Association and Environmental Mutagen Society of India, India. Prof. Ali is handling many projects of national and international importance. He also has to his credit 65 research publications in peer-reviewed international journals and multiple book chapters in edited volumes with international publishers. Prof. Ali is on editorial board panel and reviewer of several high-impact international scientific journals from Springer, Elsevier and John Wiley. He also has served as Executive Editor of Journal/ Editor Souvenir and Abstract Book for Seminar and Conference/ Workshop Guide Books. Currently, Prof. Ali is involved in studying vermin-technology, eco-toxicology, fish toxicology, DNA bar-coding, cancer biology, congenital human diseases, immunogenetic mechanisms of Recurrent Pregnancy loss etc.

Affiliations and Expertise

Cytogenetics and Molecular Biology Laboratory, Centre of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India

Shafat Ali

Shafat Ali (Ph.D.) pursued his BSc. from University of Kashmir and Masters in Zoology from Barkatullah Vishwavidyalaya, India. Currently he is engaged in research work for last 5 years at Cytogenetics and Molecular Biology Laboratory, Centre of Research for Development, University of Kashmir, Department of Biochemistry, Government Medical College, Srinagar, Jammu and Kashmir, and ICMR funded Multidisciplinary Research Unit, Government Medical College, Srinagar, Jammu and Kashmir, India, with specialization in the field of reproductive immunogenetics, cytokine biology, gynaecology and obstetrics, molecular biology, cancer biology and cytogenetics. He has 5 years of research experience and 5 years of teaching experience. He has more than 20 book chapters, several edited books and numerous peer-reviewed, international research publications to his credit. Mr. Ali is also the reviewer of many reputed international journals. Presently, Mr. Ali is involved in studying immunogenetic mechanisms involved in recurrent pregnancy loss

Affiliations and Expertise

Cytogenetics and Molecular Biology Laboratory, Centre of Research for Development, University of Kashmir, Jammu and Kashmir, India

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