2nd Edition - January 1, 1973

Write a review

  • Author: Alfred J. Crowle
  • eBook ISBN: 9781483267272

Purchase options

Purchase options
DRM-free (PDF, EPub, Mobi)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed. Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data. The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.

Table of Contents

  • Preface to the First Edition


    1. Basic Information



    The Precipitin Reaction

    Other Serologic Reactions



    Other Methods of Reactant Migration

    2. General Information



    Immunization Protocols

    Collection and Care of Antiserum

    Nonantibody Precipitins

    Preparation of Antigens

    Media for Immunodiffusion

    Composition of Immunodiffusion Test Solvents

    Environmental Conditions for Immunodiffusion Tests


    Reaction Enhancement

    Nonspecific Precipitation in Immunodiffusion Tests

    Washing and Staining Immunodiffusion Patterns

    Observing Recording, and Photographing Immunodiffusion Reactions

    3. Single Diffusion Tests

    Mechanisms of Single Diffusion Tests

    Selected Single Diffusion Techniques


    4. Double Diffusion Tests

    Characteristics and Mechanisms

    Selected Double Diffusion Techniques

    Sensitivity of Double Diffusion Tests

    5. Immunoelectrophoresis

    Theory and Interpretation of Immunoelectrophoresis

    Immunoelectrophoresis Techniques

    6. Electroimmunodiffusion


    Theory and Mechanisms


    7. Ancillary Immunodiffusion Techniques

    Alternative Methods for Detecting Antigen-Antibody Reactions

    Auxiliary Indicators for Antigen-Antibody Reaction

    Novel Varieties of Immunodiffusion

    8. History



    Appendix I. Adjuvants

    Appendix U. Selected Immunodiffusion Electrolyte Solutions

    Appendix III. Selected Inmiunoelectrophoresis and Electroinmiunodiffusion Buffers

    Appendix IV. Immunochromatography Buffers

    Appendix V. Selected Protein Stains

    Appendix VI. Selected Lipid Stains

    Appendix VII. Selected Polysaccharide Stains

    Appendix VIII. Selected Nucleic Acid Stains

    Appendix IX. Selected Double Stains

    Subject Index

Product details

  • No. of pages: 560
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9781483267272

About the Author

Alfred J. Crowle

Ratings and Reviews

Write a review

There are currently no reviews for "Immunodiffusion"