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Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed. Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data. The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.
Preface to the First Edition
1. Basic Information
The Precipitin Reaction
Other Serologic Reactions
Other Methods of Reactant Migration
2. General Information
Collection and Care of Antiserum
Preparation of Antigens
Media for Immunodiffusion
Composition of Immunodiffusion Test Solvents
Environmental Conditions for Immunodiffusion Tests
Nonspecific Precipitation in Immunodiffusion Tests
Washing and Staining Immunodiffusion Patterns
Observing Recording, and Photographing Immunodiffusion Reactions
3. Single Diffusion Tests
Mechanisms of Single Diffusion Tests
Selected Single Diffusion Techniques
4. Double Diffusion Tests
Characteristics and Mechanisms
Selected Double Diffusion Techniques
Sensitivity of Double Diffusion Tests
Theory and Interpretation of Immunoelectrophoresis
Theory and Mechanisms
7. Ancillary Immunodiffusion Techniques
Alternative Methods for Detecting Antigen-Antibody Reactions
Auxiliary Indicators for Antigen-Antibody Reaction
Novel Varieties of Immunodiffusion
Appendix I. Adjuvants
Appendix U. Selected Immunodiffusion Electrolyte Solutions
Appendix III. Selected Inmiunoelectrophoresis and Electroinmiunodiffusion Buffers
Appendix IV. Immunochromatography Buffers
Appendix V. Selected Protein Stains
Appendix VI. Selected Lipid Stains
Appendix VII. Selected Polysaccharide Stains
Appendix VIII. Selected Nucleic Acid Stains
Appendix IX. Selected Double Stains
- No. of pages:
- © Academic Press 1973
- 1st January 1973
- Academic Press
- eBook ISBN:
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