Immunobiology of Transfer Factor

Immunobiology of Transfer Factor

1st Edition - January 1, 1983

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  • Editors: Charles H. Kirkpatrick, Denis R. Burger, H. Sherwood Lawrence
  • eBook ISBN: 9781483277684

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Immunobiology of Transfer Factor compiles research papers presented at the Fourth International Transfer Factor Workshop, held at the Given Institute of Pathobiology in Aspen, Colorado, on October 3-6, 1982. This book focuses on the immunologic effects of transfer factor, which are supported by in vitro and in vivo experiments that indicate immunologically specific interactions between transfer factor and antigens. The topics include the selective removal of transfer factor activity with antigen, antigen-specific suppressor factor in human leukocyte dialysates, and specific suppressor dialysates from mice. The kinetics of immune response and production of transfer factor in bovine, dialyzable leukocyte extracts in pulmonary diseases, and mechanisms of action of human transfer factor are also elaborated. This compilation is suitable for microbiologists, immunologists, and specialists researching on transfer factor.

Table of Contents

  • Contributors



    The Merrill W. Chase Prize in Cellular Immunology

    Section I. The Nature of Transfer Factor

    The Immunological Enigma of Transfer Factor

    Human Transfer Factor: Specificity and Structural Models

    Human Transfer Factor: Exogenous Labeling, Purification, and Role of Ribonucleic Acid Segment

    Selective Removal of Transfer Factor Activity with Antigen

    Antigen-Specific Inducer Factor in Human Leukocyte Dialysates: A Product of TH Cells which Binds to Anti-V Region and Anti-La Region Antibodies

    Antigen-Specific Suppressor Factor in Human Leukocyte Dialysates: A Product of Ts Cells which Binds to Anti-V Region and Anti-La Region Antibodies

    Isolation and Purification of Antigen-Specific Inducer and Suppressor Factors from Pooled Leukocyte Dialysates of Unselected Donors by Affinity Adsorption

    Section II. Studies of Dialyzable Leukocyte Extracts in Animals

    Dialyzable Leukocyte Extract Containing Transfer Factor—Its Future in Veterinary Medicine

    Effect of Dialyzable Leucocyte Extract and Other Tissue Dialysates on Listeria Resistance

    Osteosarcoma-Specific Dialyzable Extracts: Prophylaxis Post Surgery in an Animal Model of Human Osteosarcoma

    Antigen-Specific Transfer Factor Induced in Mice by an Attenuated Virus from the Tick-Borne Encephalitis Complex: Biological, Histological, and Concentration Studies

    Antigen-Specific Suppressor Factor in Human Leukocyte Dialysates Suppresses in Vivo Footpad Reactivity in Immunized BALB/c Mice

    Specific Suppressor Dialysates from Mice

    Kinetics of Immune Response and Production of Transer Factor in Bovine

    Transfer of Cell-Mediated Immunity in Vitro to Human Lymphocytes Using Dialyzable Leukocyte Extracts from Immune Burros

    Section III. Studies of Dialyzable Leukocyte Extracts in ManThe Use of Antigen Specific Transfer Factor in the Management of Infections with Herpes Viruses

    Specific Bovine Transfer Factor for the Treatment of Herpes Infections

    Oral Bovine Transfer Factor (OTF) Use in the Hyper-IgE Syndrome

    Dialyzable Leukocyte Extracts in Pulmonary Diseases (Lung Cancer and Recurrent Bronchitis)

    Clinical Use of Leukocyte Dialysate (Transfer Factor) in Osaka Area of Japan

    Clinical Applications of the Leukocyte Migration Inhibition Assay—New Methods for Determining Transfer Factor Potency and for Predicting Clinical Response

    The Effects of Immune and Nonimmune Dialyzable Leucocyte Extracts on KLH and HCH Reactivity in Unprimed Human Recipients: A Double Blind Study

    Section IV. In Vitro Activities in Dialyzable Leukocyte Extracts

    Mechanism(s) of Action of Human Transfer Factor: Insights Obtained from Studying "Antigen-Liberated Transfer Factor" Specific for Tuberculin

    Dialyzable Leukocytes Extracts (D.L.E.) and Theophylline-Treated Lymphocytes

    Dialyzable Leucocyte Extract Stimulates cAMP in Τγ Lymphocytes: Lack of Fc-Receptor Induction or NK-Cell Activation

    Porcine Spleen Cell Dialysate Increases the Phagocytic Capacity and Decreases Prostaglandin Levels of Peritoneal Macrophages in Mouse

    Initial Characterization of an Ampliative Nucleoside Isolated from Human Dialyzable Leukocyte Lysate

    Immunochemical and Physical-Chemical Evidence for the Presence of Thymosin AlpharPeptide in Dialyzable Leukocyte Extracts

    Thymosin α1-Like Material in Dialy sates of Leukocyte Extracts

    Transfer Factor and Immune RNA

    Closing Comments


Product details

  • No. of pages: 462
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 1, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9781483277684

About the Editors

Charles H. Kirkpatrick

Denis R. Burger

H. Sherwood Lawrence

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