Immunity, Cancer, and Chemotherapy

Immunity, Cancer, and Chemotherapy

Basic Relationship on the Cellular Level

1st Edition - January 1, 1967

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  • Editor: Enrico Mihich
  • eBook ISBN: 9781483259000

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Description

Immunity, Cancer, and Chemotherapy focuses on the interference of drugs on antibody response and transplantation immunity. The selection first offers information on the effects of immunosuppressive drugs on cellular changes after antigenic stimulation and specialized cell function in the lymphoid and reticuloendothelial cell series. Topics include effects of immunosuppressive drugs on the sensitization process; cellular changes in lymphoid tissue following sensitization; and demonstration of differences in antigen handling among cells of the reticuloendothelial system. The text also takes a look at allogeneic inhibition and its possible relation to cell-bound immunity in vitro and the effects of immunosuppressive drugs at various stages of differentiation of immunologically competent cells. The publication examines a study of antibody-containing cells in the course of immunization and cellular differentiation during immune responses studied with electron microscope and radioautography. The text also elaborates on ambiguity in the translation of genetic code into proteins, induced by aminoglycoside antibiotics and immunosuppressive agents and cellular kinetics of immune response. The selection is a dependable source of information for readers interested in effects of drugs on antibody response and transplantation immunity.

Table of Contents


  • articipants

    List of Contributors

    Foreword

    Preface

    The Effect Of Immunosuppressive Drugs On Cellular Changes After Antigenic Stimulation

    I. Cellular Changes In Lymphoid Tissue Following Sensitization

    II. Effect of Immunosuppressive Drugs on the Sensitization Process

    III. Conclusions

    References

    Discussion

    Specialized Cell Function In The Lymphoid And Reticuloendothelial Cell Series

    I. Demonstration of Differences In Antigen Handling Among Cells of the Reticuloendothelial System

    II. Specialization of Cells of the Lymphoid System

    III. Concluding Remarks

    References

    Discussion

    Allogeneic Inhibition And Its Possible Relation To Cell-Bound Immunity In Vitro

    I. Attempts to Demonstrate Allogenic Inhibition in Vitro

    II. Summary

    Acknowledgments

    References

    Discussion

    The Effect Of Immunosuppressive Drugs At Various Stages Of Differentiation Of Immunologically Competent Cells

    I. Definition Of The Inductive Phase By The Use Of Metabolic Inhibitors

    II. The Influence Of Metabolic Inhibitors On Antibody Production

    III. The Influence Of Inhibitors On The Preparation For The Secondary Response

    IV. The Influence Of Inhibitors On The Secondary Response

    V. Studies On Immunological Inhibition (Tolerance) Using Metabolic Inhibitors

    VI. Unitarian Concept Of Immune Reactions Based On The Model Of Immunological Cell Differentiation

    References

    Discussion

    A Study Of Antibody-Containing Cells In The Course Of Immunization

    I. Comparison Between The Results Obtained With The ICA And The Hemolysis Plaque Formation Techniques

    II. Application Of The ICA Method To The Study Of Cells Producing Antibodies Against Haptens

    III. Inhibition Of ICA By Heterologous Antibodies Against Immunoglobulins

    IV. Kinetics Of The Appearance Of "Rosette"-Forming Cells In The Spleen Of Mice Immunized Intravenously With Sheep Erythrocytes

    References

    Discussion

    Cellular Differentiation During Immune Responses Studied With The Electron Microscope And Radioautography

    Text

    References

    Discussion

    Concerning The Recognition Reaction And Transfer RNA In Protein Synthesis

    Text

    References

    Discussion

    Ambiguity In The Translation Of The Genetic Code Into Proteins, Induced By Aminoglycoside Antibiotics

    Text

    References

    Discussion

    Macrophage RNA And Antibody Synthesis

    Text

    References

    Discussion

    The Role Of Antigen In The Regulation Of Antibody Formation

    I. Kinetics Of Antibody Formation To Bacteriophage φX 174 In Guinea Pigs

    II. Immune Functions of Individual Antibody-Forming Cells

    References

    Discussion

    Alteration Of Immunity By Antimetabolites

    Text

    References

    Discussion

    Immunosuppressive Agents And The Cellular Kinetics Of The Immune Response

    I. Introduction

    II. Materials And Methods

    III. Results

    IV. Discussion

    V. Summary

    References

    Discussion

    Immunochemical Studies Of Mammalian Cell Membranes

    I. Introduction

    II. The Immunochemical Problem

    III. Methods For The Preparation Of Plasma Membranes

    IV. Recognition Marker For Plasma Membrane

    V. Composition Of Plasma Membrane Preparations

    VI. General Discussion

    References

    Discussion

    Tumor Antigens

    Text

    References

    Discussion

    Expression Of Antigens In Normal Mammalian Cells

    I. Introduction

    II. Cellular Antigens In Tissue Culture

    III. Embryonic Differentiation Of Antigens

    IV. Induction Of Antigens In The Thymus

    V. Modification Of The Expression Of Normal Tissue Antigens In Vivo

    VI. Differentiation Of Immunoglobulin-Producing Cells

    VII. Closing Comments

    References

    Discussion

    Mechanism Of Complement Action And Means Of Complement Depletion

    I. Physiogenic And Pathogenic Role Of Complement

    II. Mechanism Of Action Of Human Complement

    III. Enhancement Of Complement

    IV. Inhibition Of Complement

    V. Inactivation Of C'3 By Cobra Factor

    References

    Discussion

    Immunogenicity Of Synthetic Polymers Of Amino Acids; Role Of Carrier And Genetic Background

    I. Introduction

    II. Immunogenicity Of Linear Polymers Of α-L- And α-D-Amino Acids

    III. Role Of Carrier In Influencing The Immune Response

    IV. Genetic Control Of Immune Response

    References

    Discussion

    Studies On Transplantation

    I. Past Efforts

    II. Causes Of Failure

    III. Histocompatibility Matching

    IV. Improved Immunosuppression

    V. Other Organs

    References

    Discussion

    Author Index

    Subject Index




Product details

  • No. of pages: 414
  • Language: English
  • Copyright: © Academic Press 1967
  • Published: January 1, 1967
  • Imprint: Academic Press
  • eBook ISBN: 9781483259000

About the Editor

Enrico Mihich

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