Immune Recognition

Immune Recognition

1st Edition - January 1, 1975

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  • Editor: Alan Rosenthal
  • eBook ISBN: 9780323142137

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Immune Recognition is a modified compilation of an experimental leukocyte culture conference about various aspects of macrophage and lymphocyte biology in relation to the eponymous central theme. The book is divided into nine sections. Section I covers non-antigenic signals and receptors for lymphocyte activation; the recognition of chemically modified autologous cells; surface membrane saccharides; and B and T cell activation. Section II is about antigenic signals; the activation of macrophages; and the induction of autosensitization of initiator lymphocytes. Sections III and IV discuss the early membrane and biochemical events in lymphocyte activation. Sections V to IX cover the coupling of cytoplasmic and nuclear events to membrane cycles; cellular and molecular basis of cell recognition and interaction in nonlymphocyte systems; the genetic control of immunocompetent cell interactions; and cellular mechanisms that regulate the immune response. The text is intended for doctors who specialize in immunology and want to know more about the different factors that cause the recognition of the immune system.

Table of Contents

  • Participants



    Section I. Signals for Lymphocyte Activation I: Nonantigenic Signals and Receptors

    Scratching the Surface

    Recognition of Chemically Modified Autologous Cells: Importance of the Murine Major Histocompatibility Complex

    Lymphocyte Activation Induced by Modifications of Surface Membrane Saccharides

    Signals and Receptors in B Cell Activation

    Differential Stimulation of Murine T and B Cell Populations by Purified Mitogens from Poke weed


    Session Summary

    Section II. Signals for Lymphocyte Activation II: Antigenic Signals and Receptors

    The Mechanism of Action of Macrophages in the Activation of T-Lymphocytes In Vitro by Antigens and Mitogens

    The Role of Antigen Presentation in B Cell Activation: Analysis with Two DNP-Polymer Conjugates

    Immune Response to Phosphorylcholine: A Model System for the Study of Antibody Diversity

    Recognition in MLC and CML: The LD-SD Dichotomy

    Molecular Events in the Induction of Autosensitization of Initiator T Lymphocytes

    Generation of Cytotoxic Lymphocytes and Inhibition of Cell-Mediated Lympholysis by Soluble HL-A Antigens

    The Specificity of Guinea Pig T Lymphocyte Responses to Chemically Defined Antigens


    Section III. Early Events in Lymphocyte Activation I: Membrane and Biochemical Events

    Regulation of Cell Surface Topography

    The Modulation of Immunoglobulin in B Lymphocytes and Its Relevance to Immune Stimulation

    The Role of Phospholipids in Lymphocyte Activation

    Modulation in the Organization of Plasma Membranes Intramembranous Particles in Fibroblasts and Lymphocytes


    Section IV. Early Events in Lymphocyte Activation II: Membrane and Biochemical Events

    Possible Mechanisms of Lymphocyte Activation

    The Role of Cyclic Nucleotides in Lymphocyte Activation

    Cyclic GMP and Lymphocyte Activation

    Lymphocyte Transformation and Cation Transport


    Section V. Coupling of Cytoplasmic and Nuclear Events to Membrane Signals

    Coupling of Nuclear and Cytoplasmic Events to Membrane Signals

    The Role of Divalent Cations in the Initiation of Lymphocyte Activation

    Microtubules, Cyclic GMP and Control of Cell Surface Topography

    Receptor-Cytoplasmic Interactions and Lymphocyte Activation

    Lymphocyte Junctions: Permeability and Structure

    The Relationship between "Early Events" and DNA Synthesis in Mitogen Stimulated Lymphocytes


    Session Summary

    Section VI. Cellular and Molecular Basis of Cell Recognition and Interaction in Nonlymphocyte Systems

    Studies on the Cell Surface Receptors for IgE

    Cell Interaction in the Packaging of Lysosomal Enzymes

    Studies on the Hepatic Recognition and Removal of Circulating Glycoproteins

    Intercellular Recognition and Communication by Cell Surface Glycosyltransferases and Oligosaccharides

    Section VII. The Role of The Macrophage in The Initiation and Regulation of The Immune Response

    The Saga of the Macrophage

    The Role of Macrophages in T Lymphocyte Antigen Recognition

    Secretion by Macrophages of Two Molecules Modulating Cell Proliferation

    GVH Induced Immunosuppression: Regulatory Function of Macrophages in the Humoral Immune Response

    A Novel Adherent Cell in Mouse Lymphoid Organs

    The Macrophage as Secretory Cell


    Section VIII. Genetic Control of Immunocompetent Cell Interactions

    Genetic Control of Immunocompetent Cell Interactions

    Genetic Control of Macrophage-T Lymphocyte Interaction

    On the Mechanism of Alloantiserum Mediated Suppression of Histocompatibility-Linked IrGene Controlled Immune Responses

    In Vitro Studies of the Cellular Interactions in an Antibody Response Controlled by an Immune Response (Ir) Gene(s)

    Genetic Control of the Stimulator and Effector Function in Allogeneic Lymphocyte Interaction: The Expression of/ Region Gene Products on T and B Lymphocytes


    Session Summary

    Section IX. Regulation of The Immune Response: Cellular Mechanisms

    Regulation of Interaction of Immunocompetent Cells

    Evidence for the Control of Lymphocyte Interactions by Gene Products of the / Region of the H-2 Complex

    Cell Interactions in Antibody Production—Problems of Heterogeneity, Diversity and Regulation

    Antigen-Specific Enhancing and Suppressive T Cell Factors in the Regulation of Antibody Response

    Antigen-Specific T Cell Factor in Cell Cooperation and Genetic Control of the Immune Response

    Tolerance Induction Towards Determinants of the Major Histocompatibility Complex: Evidence for Deletion of T Cell Subsets

    Suppression of Lymphocyte Proliferative Responses by Murine Lymphoma Cells

    Suppressor and Helper Effects of Sensitized T-Cell Subpopulations on Proliferative T-Cell Responses


    Session Summary

    Author Index

    Subject Index

Product details

  • No. of pages: 876
  • Language: English
  • Copyright: © Academic Press 1975
  • Published: January 1, 1975
  • Imprint: Academic Press
  • eBook ISBN: 9780323142137

About the Editor

Alan Rosenthal

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