Immune Recognition

1st Edition - January 1, 1975
Editor: Alan Rosenthal
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 2 1 3 - 7

Immune Recognition is a modified compilation of an experimental leukocyte culture conference about various aspects of macrophage and lymphocyte biology in relation to the eponymous… Read more

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Immune Recognition is a modified compilation of an experimental leukocyte culture conference about various aspects of macrophage and lymphocyte biology in relation to the eponymous central theme. The book is divided into nine sections. Section I covers non-antigenic signals and receptors for lymphocyte activation; the recognition of chemically modified autologous cells; surface membrane saccharides; and B and T cell activation. Section II is about antigenic signals; the activation of macrophages; and the induction of autosensitization of initiator lymphocytes. Sections III and IV discuss the early membrane and biochemical events in lymphocyte activation. Sections V to IX cover the coupling of cytoplasmic and nuclear events to membrane cycles; cellular and molecular basis of cell recognition and interaction in nonlymphocyte systems; the genetic control of immunocompetent cell interactions; and cellular mechanisms that regulate the immune response. The text is intended for doctors who specialize in immunology and want to know more about the different factors that cause the recognition of the immune system.

Participants

Preface

Acknowledgments

Section I. Signals for Lymphocyte Activation I: Nonantigenic Signals and Receptors

Scratching the Surface

Recognition of Chemically Modified Autologous Cells: Importance of the Murine Major Histocompatibility Complex

Lymphocyte Activation Induced by Modifications of Surface Membrane Saccharides

Signals and Receptors in B Cell Activation

Differential Stimulation of Murine T and B Cell Populations by Purified Mitogens from Poke weed

Discussion

Session Summary

Section II. Signals for Lymphocyte Activation II: Antigenic Signals and Receptors

The Mechanism of Action of Macrophages in the Activation of T-Lymphocytes In Vitro by Antigens and Mitogens

The Role of Antigen Presentation in B Cell Activation: Analysis with Two DNP-Polymer Conjugates

Immune Response to Phosphorylcholine: A Model System for the Study of Antibody Diversity

Recognition in MLC and CML: The LD-SD Dichotomy

Molecular Events in the Induction of Autosensitization of Initiator T Lymphocytes

Generation of Cytotoxic Lymphocytes and Inhibition of Cell-Mediated Lympholysis by Soluble HL-A Antigens

The Specificity of Guinea Pig T Lymphocyte Responses to Chemically Defined Antigens

Discussion

Section III. Early Events in Lymphocyte Activation I: Membrane and Biochemical Events

Regulation of Cell Surface Topography

The Modulation of Immunoglobulin in B Lymphocytes and Its Relevance to Immune Stimulation

The Role of Phospholipids in Lymphocyte Activation

Modulation in the Organization of Plasma Membranes Intramembranous Particles in Fibroblasts and Lymphocytes

Discussion

Section IV. Early Events in Lymphocyte Activation II: Membrane and Biochemical Events

Possible Mechanisms of Lymphocyte Activation

The Role of Cyclic Nucleotides in Lymphocyte Activation

Cyclic GMP and Lymphocyte Activation

Lymphocyte Transformation and Cation Transport

Discussion

Section V. Coupling of Cytoplasmic and Nuclear Events to Membrane Signals

Coupling of Nuclear and Cytoplasmic Events to Membrane Signals

The Role of Divalent Cations in the Initiation of Lymphocyte Activation

Microtubules, Cyclic GMP and Control of Cell Surface Topography

Receptor-Cytoplasmic Interactions and Lymphocyte Activation

Lymphocyte Junctions: Permeability and Structure

The Relationship between "Early Events" and DNA Synthesis in Mitogen Stimulated Lymphocytes

Discussion

Session Summary

Section VI. Cellular and Molecular Basis of Cell Recognition and Interaction in Nonlymphocyte Systems

Studies on the Cell Surface Receptors for IgE

Cell Interaction in the Packaging of Lysosomal Enzymes

Studies on the Hepatic Recognition and Removal of Circulating Glycoproteins

Intercellular Recognition and Communication by Cell Surface Glycosyltransferases and Oligosaccharides

Section VII. The Role of The Macrophage in The Initiation and Regulation of The Immune Response

The Saga of the Macrophage

The Role of Macrophages in T Lymphocyte Antigen Recognition

Secretion by Macrophages of Two Molecules Modulating Cell Proliferation

GVH Induced Immunosuppression: Regulatory Function of Macrophages in the Humoral Immune Response

A Novel Adherent Cell in Mouse Lymphoid Organs

The Macrophage as Secretory Cell

Discussion

Section VIII. Genetic Control of Immunocompetent Cell Interactions

Genetic Control of Immunocompetent Cell Interactions

Genetic Control of Macrophage-T Lymphocyte Interaction

On the Mechanism of Alloantiserum Mediated Suppression of Histocompatibility-Linked IrGene Controlled Immune Responses

In Vitro Studies of the Cellular Interactions in an Antibody Response Controlled by an Immune Response (Ir) Gene(s)

Genetic Control of the Stimulator and Effector Function in Allogeneic Lymphocyte Interaction: The Expression of/ Region Gene Products on T and B Lymphocytes

Discussion

Session Summary

Section IX. Regulation of The Immune Response: Cellular Mechanisms

Regulation of Interaction of Immunocompetent Cells

Evidence for the Control of Lymphocyte Interactions by Gene Products of the / Region of the H-2 Complex

Cell Interactions in Antibody Production—Problems of Heterogeneity, Diversity and Regulation

Antigen-Specific Enhancing and Suppressive T Cell Factors in the Regulation of Antibody Response

Antigen-Specific T Cell Factor in Cell Cooperation and Genetic Control of the Immune Response

Tolerance Induction Towards Determinants of the Major Histocompatibility Complex: Evidence for Deletion of T Cell Subsets

Suppression of Lymphocyte Proliferative Responses by Murine Lymphoma Cells

Suppressor and Helper Effects of Sensitized T-Cell Subpopulations on Proliferative T-Cell Responses

Discussion

Session Summary

Author Index

Subject Index