Immune Recognition and Evasion: Molecular Aspects of Host–Parasite Interaction

Immune Recognition and Evasion: Molecular Aspects of Host–Parasite Interaction

1st Edition - January 1, 1990

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  • Editor: L.H.T. Van Der Ploeg
  • eBook ISBN: 9780323155663

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Description

Immune Recognition and Evasion: Molecular Aspects of Host-Parasite Interaction reviews recent advances in understanding the genetic basis of host-parasite interactions, with emphasis on antigenic epitopes, the genetics of parasites, the molecular mechanisms of immune recognition and evasion, and the way that cytokines and hormones act on host-parasite interactions. Organized into four parts encompassing 25 chapters, this volume begins with an overview of the genomic organization of the T cell receptor genes and the contribution of non-B DNA structures to switch recombination in immunoglobulin genes. It then discusses signal transduction by class II molecules encoded by the major histocompatibility complex la and the biological consequences of this process; allelic polymorphism of HLA class II antigens and its connection to the molecular basis of autoimmunity; mimicry between HLAB27 and bacteria; and genetic control of susceptibility to helminth infection. The reader is also introduced to recognition of protein antigens by antibodies; recognition of influenza antigens by class I-restricted cytotoxic T lymphocytes; the biochemical basis of cachexia of infection; mechanisms of antigenic variation in Plasmodium; and rational design of trypanocidal drugs. Geneticists and molecular biologists will gain valuable information from this book.

Table of Contents


  • Preface

    Part I Mechanisms and Genetic Control of Immune Recognition

    1 Genomic Organization of the T Cell Receptor

    Introduction

    Genomic Organization of the T Cell Receptor Genes

    Conclusion

    References

    2 Contribution of Non-B DNA Structures to Switch Recombination in Immunoglobulin Genes

    Introduction

    Results

    Discussion

    References

    3 Biological Consequences of Signal Transduction by Class II Molecules Encoded by the Major Histocompatibility Complex la

    Introduction

    Results and Discussion

    Conclusions

    References

    4 Allelic Polymorphism of HLA Class II Antigens: Clues to the Molecular Basis of Autoimmunity

    Introduction

    M H C Class II Structure and Function

    HLA and Disease

    Conclusions

    References

    5 Mimicry between HLA-B27 and Bacteria: A Spurious Finding or the Link Connecting HLA-B27 and Arthritogenic Bacteria?

    Introduction

    Cross-Reactivity Using Monoclonal Anti-B 2 7 Antibodies

    Evidence for Mimicry Using Synthetic Peptides

    General Conclusion

    References

    6 Genetic Control of Predisposition to Helminth Infection

    Introduction

    Generation of Predisposition

    Analysis of Genetically Determined Predisposition

    Conclusions

    References

    Part II Structure of Antigenic Epitopes: Parasite Antigens

    7 Recognition of Protein Antigens by Antibodies: Crystal Structure of Antibody Fab Fragments Complexed with Influenza Virus Neuraminidase

    Introduction

    Structure of Fab-NA Complexes

    Escape Mutants

    Structure of Escape Mutants

    Mechanisms of Inhibition of NA Activity by Antibody

    Antibody Distortion

    References

    8 Recognition of Influenza Antigens by Class I-Restricted Cytotoxic T Lymphocytes

    Introduction

    Slightly Altered Versions of Self

    How Are Cytoplasmic Antigens Recognized at the Cell Surface?

    Recent Work

    References

    9 The Origin of the Autoimmune Pathology Associated with Trypanosoma cruzi Infection

    Introduction

    Conclusions

    References

    10 Advances toward a Vaccine against Schistosomiasis

    Introduction

    Protective Immunity against Schistosomes

    Target Antigens of Immunity

    Conclusions

    References

    11 Stress Proteins as Immune Targets in Bacterial and Parasitic Infections

    Introduction

    Results and Discussion

    References

    Part III Cytokines and Hormones in Host-Parasite Interaction

    12 Autocrine-Stimulated Immortalization of Lymphocytes by the Parasite Theileria parva

    Introduction

    Life Cycle

    Lymphocyte Proliferation in Vitro

    Growth of Theileria in Nonbovine Cells and Animals

    Host-Parasite Relationship

    References

    13 Characteristics, Distribution, and Possible Evolutionary Importance of the Human Growth Hormone-Like Factor from Plerocercoids of the Tapeworm Genus Spirometra

    Introduction

    Characteristics of Growth Hormone

    Characteristics of Plerocercoid Growth Factor

    Possible Adaptive Roles for Plerocercoid Growth Factor

    Summary and Hypothesis

    References

    14 The Biochemical Basis of Cachexia of Infection

    Introduction

    History of the Isolation of Cachectin

    Catabolic Cellular Responses to Cachectin/TNF

    Cachectin TNF-Induced Cachexia

    Summary and Future Directions

    References

    Part IV Genetic Mechanisms in Immune Evasion: Molecular Genetics of Parasitic Organisms

    15 Escape from the Host Humoral Response: Examples from Two Microbial Pathogens

    Text

    References

    16 Multiphasic Antigenic Variation in the Bacterium that Causes Relapsing Fever

    Introduction

    Biology of Relapsing Fever

    The Variable Antigens: Outer Membrane Proteins

    Antigenic Variation: The Consequences of DNA Rearrangements

    The vmp Genes: On Linear Plasmids

    Model Mechanisms of vmp Gene Switching

    References

    17 Mechanisms of Antigenic Variation in Plasmodium

    Introduction

    Variations in the Tandem Repeats of Malaria Antigens

    Transpositions and Rearrangements Involving Subtelomeric Regions of Chromosomes

    Point Mutations and Focal Deletions

    Conclusions

    References

    18 Genome Structure, Transcriptional Control, and Nuclear Organization in Trypanosoma brucei

    The Cell Surface Coat and Antigenic Variation

    Chromosome Structure

    DNA Recombinational Events and Differential VSG Gene Expression

    Identification of Transcription Initiation Sites

    Discontinuous Transcription and Trans-Splicing

    ?-Amanitin-Resistant Transcription of Protein-Coding Genes and Telomeres

    Analysis of Nuclear Structure

    Concluding Remarks

    References

    19 Antigenic Variation in Giardia lamblia

    Text

    References

    20 Recent Developments in the Analysis of Chromosome-Sized DNA and Their Application to Studies on Giardia lamblia and Trypanosoma brucei

    Introduction

    Principles of Pulsed-Field Gel Electrophoresis

    Sizing Large DNA Molecules

    Enzymatic Manipulation of Intact Chromosomes

    Pulsed-Field Gel Electrophoretic Analysis of the Giardia lamblia Genome

    The Large Chromosomes of Trypanosoma brucei

    Prospectus

    References

    21 Identification and Comparison of Putative Chlamydial Promoter Elements

    Introduction

    Results

    Conclusions

    References

    22 The Double-Stranded RNA Virus of Giardia lamblia

    Introduction

    Results

    Discussion

    References

    23 Viruses and Episomes of Leishmania

    Introduction

    Methods

    Results

    Discussion

    References

    24 gp63 as a Surface Metalloproteinase in Leishmania Virulence: Molecular Determinants of Proteolytic Activity and N-Glycosylation

    Introduction

    gp63 as a Zn-Proteinase

    Predicted Amino Acid Sequences at Zinc-Binding and Catalytic Sites of gp63

    Functional Significance of gp63 in Leishmanial Virulence

    Regulation of gp63 Expression by N-Glycosylation

    Increased Dolichol Pathway Enzyme for N-Glycosylation and Leishmania Virulence in Tunicamycin-Resistant Variants

    Glycosyltransferase Gene Amplification Responsible for Tunicamycin Resistance and Leishmania Virulence?

    Summary

    References

    25 Rational Design of Trypanocidal Drugs

    Trypanosome Glycolysis

    Glycolytic Enzymes from Trypanosomes Are Different

    Toward the Rational Design of Selective Inhibitors

    Antihot Spot Compounds

    Outlook

    References

    Index






Product details

  • No. of pages: 330
  • Language: English
  • Copyright: © Academic Press 1990
  • Published: January 1, 1990
  • Imprint: Academic Press
  • eBook ISBN: 9780323155663

About the Editor

L.H.T. Van Der Ploeg

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