Description

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future.

Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog.

These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.

Key Features

  • Brings together perspectives leading laboratories and clinical research groups to highlight advances from bench to the bedside
  • Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic HSCT scenarios
  • Categorizes the published advances in various aspects of immune biology of allegeneic HSCT to illustrate opportunities for clinical applications

Readership

Stem cell biologists, cancer biologists, immunologists, hematologists, cardiologists, oncologists, pathologist

Table of Contents

Contributors

Foreword

Abbreviations

CH 1. Overview of the immune biology of allogeneic hematopoietic stem cell transplantation

Introduction

Immune rejection

Immune deficiency

GVHD pathophysiology

The graft-versus-leukemia effect

References

CH 2. The HLA system in hematopoietic stem cell transplantation

Introduction

Classical HLA

The role of classical HLA in unrelated donor hematopoietic cell transplantation

The clinical significance of non-classical HLA genes: HLA-E, (HLA-F), HLA-G and MIC genes

Conclusions

Acknowledgments

References

CH 3. The impact of minor histocompatibility antigens in allogeneic stem cell transplantation

From immunobiology to the impact of mHags in GVHD and GVT

Murine mHags, challenges for the human system

Immunobiology and biochemical identity of mHags

Mechanisms of generation of mHags

The impact of individual mHags on GVHD and GVT

To match or to mismatch: paradigm shifts in the mHag field

Hematopoietic mHags: ideal targets for separating GVT from GVHD

Immunotherapeutic targeting of hematopoietic mHags

Toward a broad and more effective application of mHag therapy

Controlling naturally existing and mHag-specific CD8+ regulatory T cells

Concluding remarks

References

CH 4. In vivo imaging of graft-versus-host disease and graft-versus-leukemia

Introduction

Bioluminescence imaging

In vivo fluorescence imaging

Nuclear imaging (PET/SPECT)

Magnetic resonance imaging

Multimodal imaging of GVHD and anti-tumor responses

Advances in imaging technology

Conclusion

References

CH 5. Immune rejection: the immune biology of allogeneic hematopoietic stem cell transplantation (from mice to humans)

Introduction

Hematopoie

Details

No. of pages:
536
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Electronic ISBN:
9780123914651
Print ISBN:
9780124160040

About the editors

Reviews

"Socié and Blazar provide clinical and scientific researchers with 12 chapters on research on allogenic hematopoietic stem cell transplantation (HSCT) and implications for translational practice."--Reference and Research Book News, August 2013
"Bruce Blazar and Gérard Socié have put together an important book on the Immune Biology of Stem Cell Transplants. The Authors chosen for specific chapters are all recognized experts in their field. This book will be very popular among young scientists in training, as well as among experienced transplanters."--Andrea Bacigalupo, MD, Head of the Department of Hematology at Ospedale San Martino in Genoa, Italy
"Self/non-self discrimination is a fundamental requirement of life. Accordingly, vertebrates are equipped with an adaptive immune system that is eminently self-referential: it is selected on self-molecules, sustained by self-molecules, and activated in the presence of self-molecules. Therefore, what might be the consequences of introducing a mature immune system in a novel "non-self" host? The consequences are many. Some are predictable and dreadful (e.g., graft-vs.-host disease), other unexpected and awe-inspiring (e.g., the graft-vs.-leukemia effect). Nonetheless, when allogeneic hematopoietic stem cell transplantation was introduced in medicine, it would have been impossible to anticipate its profound impact on our understanding of immunobiology. Gérard Socié and Bruce Blazar have taken up the gauntlet. They have assembled a dream team of experts who present a clear, comprehensive, critical and exciting picture of the current knowledge in immunobiology of allogeneic hematopoietic stem cell transplantation."--Claude Perreault, PhD, Professor and Canada Research Chair in Immunobiology Institute for Research in Immunology and Cancer Université de Montréal