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Hypothalamic Integration of Energy Metabolism - 1st Edition - ISBN: 9780444522610, 9780080463483

Hypothalamic Integration of Energy Metabolism, Volume 153

1st Edition

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Editors: A. Kalsbeek Eric Fliers Michel A. Hofman D.F. Swaab Eus JW Van Someren R.M. Buijs
Hardcover ISBN: 9780444522610
eBook ISBN: 9780080463483
Imprint: Elsevier Science
Published Date: 21st August 2006
Page Count: 430
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Table of Contents

List of Contributors. Preface. Acknowledgements.


  1. The human hypothalamus in metabolic and episodic disorders.
  2. Synaptic plasticity mediating Leptin's effect on metabolism.
  3. The hypothalamus, hormones and hunger: alterations in human obesity and illness.
  4. Glucocorticoids, chronic stress, and obesity.
  5. Design and synthesis of (ant)-antagonists that alter appetite and adiposity.
  6. Monogenic human obesity syndromes.

II. HYPOTHAMAMIC INTEGRATION OF BLOOD BORNE SIGNALS 7. The selfish brain: competition for energy resources. 8. Integration of metabolic stimuli in the hypothalamic arcuate nucleus. 9. Adipokines that link obesity and diabetes to the hypothalamus.

III. HYPOTHALAMIC CONTROL OF BONE AND THYROID METABOLISM 10. The circadian modulation of Leptin-controlled bone formation. 11. Hypothalamic thyroid hormone feedback in health and disease. 12. The TRH Neuron: a hypothalamic integrator of energy metabolism.

IV. RHYTHMS, SLEEP AND ENERGY METABOLISM 13. The seventeenth C.U. Ariens Kappers Lecture. An Introduction. 14. Staying awake for dinner: hypothalamic integration of sleep, feeding and circadian rhythms. 15. Circadian timing in health and disease. 16. Circadian time keeping: the daily ups and downs of genes, cells and organisms. 17. The hypothalamic clock and its control of glucose homeostatis. 18. Mechanisms and functions of coupling between sleep and temperature rhythms. 19. What can we learn from seasonal animals about the regulation of energy balance?

V. HYPOTHALAMIC INTEGRATION OF "SENSORY" INFORMATION 20. Organization of circadian functions: interaction with the body. 21. Hypoglycemia in diabetes: pathophysiological mechanisms and diurnal variation. 22. Hypothalamic integration of immune function and metabolism.

Subject Index.


The prevalence of obesity in developed countries is fast becoming a health issue on par with infectious diseases and malnutrition. Research in this area has grown substantially and includes the neurochemical pathways of the hypothalamus and its role in regulating energy expenditures in the body. This volume in the Progress in Brain Research series examines the emerging role of the hypothalamus as a crucial link between the sensing of nutrients and the control of insulin sensitivity, glucose uptake, and glucose production, the integrative role of the hypothalamus in thyroid and bone metabolism, the interaction between circadian information and energy metabolism, and the important interplay between the immune system and energy metabolism.

Key Features

· All contributors are recognized experts in their respective specialities · Provides expanded coverage of hypothalamic mechanisms involved in energy metabolism · Includes many outstanding full-colour illustrations · Contains special sections on circadian rhythms, immune system, thyroid and bone metabolism


Neuroscientists, endocrinologists, and obesity researchers.


No. of pages:
© Elsevier Science 2006
21st August 2006
Elsevier Science
Hardcover ISBN:
eBook ISBN:

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About the Editors

A. Kalsbeek

Affiliations and Expertise

The Netherlands Institute for Brain Research, Amsterdam, The Netherlands

Eric Fliers

Affiliations and Expertise

The Netherlands Institute for Brain Research, Amsterdam, The Netherlands

Michel A. Hofman

Michel A. Hofman is at Netherlands Institute for Neuroscience, Netherlands

Affiliations and Expertise

Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

D.F. Swaab

Affiliations and Expertise

Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands

Eus JW Van Someren

Affiliations and Expertise

The Netherlands Institute for Brain Research, Amsterdam, The Netherlands

R.M. Buijs

Affiliations and Expertise

Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands