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Hypothalamic Control of Lactation - 1st Edition - ISBN: 9780433289913, 9781483193038

Hypothalamic Control of Lactation

1st Edition

Monographs on Endocrinology

Author: F. G. Sulman
Editors: F. Gross A. Labhart T. Mann
eBook ISBN: 9781483193038
Imprint: Butterworth-Heinemann
Published Date: 1st January 1970
Page Count: 248
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Monographs on Endocrinology, Volume 3: Hypothalamic Control of Lactation provides information pertinent to the fundamental aspects of lactation, which is dependent upon the temporal cortex of the brain. This book discusses the manifold problems of hypothalamic lactation. Organized into four parts encompassing 30 chapters, this volume begins with an overview of the mechanisms of lactation and explores the hormone requirements for mammary development in various species. This text then examines the theory of the anterior pituitary gland being controlled by neurohumors carried through the hypophysial portal circulation. Other chapters consider the physiology of pituitary prolactin, which is distinguished from other pituitary tropins by its inhibitory regulation originating in the central nervous system. This book discusses as well the mechanism of the lactogenic effect of hypothalamic tranquilizers. The final chapter deals with the structure of the hypothalamic factors responsible for lactation. This monograph is a valuable resource for endocrinologists, scientists, students, and researchers.

Table of Contents

Part I Physiological Regulation of Lactation

Chapter 1. Mechanism of Lactation

Chapter 2. Hypothalamus-Pituitary Axis

a) Hypothalamic Control of Prolactin Secretion

b) Prolactin-Inhibiting Factor (PIF)

c) Prolactin-Releasing Factor (PRF)

d) Hypothalamic Feedback of Prolactin

e) Effect of Steroids

f) Interrelation between Pituitary Tropins

g) Suckling

h) Conclusions

Chapter 3. Prolactin

a) Introduction

b) Storage and Release

c) Properties

d) Prolactin in Body Fluids

e) Prolactin in Pituitary Tumors

f) Effect of Prolactin on Mammary Growth

g) Levels of Pituitary Prolactin in Various Stages of Lactation

h) Theories on the Mechanism of Onset of Lactation

i) Conclusion

Chapter 4. Growth Hormone

Chapter 5. Gonadotropins and Sex Steroids

Chapter 6. Adrenocorticotropin and Corticosteroids

Chapter 7. Thyrotropin and Thyroid Hormones

Chapter 8. Oxytocin and Vasopressin

Chapter 9. Parathormone and Calcitonin

Chapter 10. Insulin and Glucagon

Chapter 11. Pineal Gland

Chapter 12. Placental and Amniotic Fluid

Part II Pharmacological Regulation of Lactation

Chapter 13. Hypothalamic Lactation Produced by Psychopharmaca

a) History

b) Dissociation of Mammotropic and Sedative Effects

c) Biological Dissociation through Combined Treatment with Tranquilizers and Psycho-Stimulants

d) Chemical Dissociation by Molecular Changes of Tranquilizers

e) Studies in Hypophysectomized Rats

f) Conclusions

Chapter 14. Mammotropic Effect of Phenothiazine Derivatives

a) History

b) Mammotropic Index (MTI)

c) Body Temperature Drop (BTD)

d) Screening of Phenothiazine Derivatives

e) Screening of Phenothiazine Sulfoxides and Sulfodioxides

f) Stimulation of Synthesis and Release of Prolactin by Perphenazine

g) Intracerebral Implantation of Phenothiazine Derivatives

h) Mammotropic Effect of Fluphenazine Enanthate in the Rat

i) Comparative Study of Phenothiazine Effect on Hypothalamic Prolactin-Inhibiting Factor and MSH-Releasing Factor

j) Conclusions

Chapter 15. Mammotropic Effect of Phenothiazine-like Compounds

Chapter 16. Mammotropic Effect of Reserpine Derivatives

Chapter 17. Mammotropic Effect of Butyrophenones

Chapter 18. Mammotropic Effect of Miscellaneous Psychotropic Drugs

Chapter 19. Structure-Activity Relationship of Mammotropic Drugs and Receptor Theory

Chapter 20. Pituitary-Ovary Axis in Hypothalamic Lactation

Chapter 21. Pituitary-Adrenal Axis in Hypothalamic Lactation

Chapter 22. Pituitary-Thyroid Axis in Hypothalamic Lactation

a) Role of Thyroid in vivo and In Vitro

b) Thyroid and Hypothalamic Mammary Growth

c) Thyroid and Post-Partum Galactopoiesis

d) Conclusion

Chapter 23. Prolactin Release by Hypothalamus of Nursing Rat Mothers

Chapter 24. Prolactin as Luteotropic Hormone

Part III Prolactin Assay

Chapter 25. In Vitro Methods

a) Effect of Hypothalamus

b) Effect of Pituitary

c) Effect of Steroids

d) Effect of Neurohormones

e) Effect of Phenothiazines

f) Effect of Reserpine

g) Effect of Thyroid

h) Effect of Oxytocin

i) Conclusion

Chapter 26. In Vivo Methods

a) Rabbit Tests

b) Rat Tests

c) Pigeon Tests

d) Concentration Methods

Chapter 27. Radioimmunoassay

Part IV Problems of Lactation

Chapter 28. Lactation in Humans

a) Lactation and Post-Partum Amenorrhea

b) Inhibition of Lactation and Breast Engorgement

c) Persistence of Lactation and Menstrual Cycle

d) Sterility during Lactation

e) Galactorrhea as a General Syndrome

f) Forbes-Albright-Castillo Syndrome

g) Chiari-Frommel Syndrome

h) Sheehan's Syndrome

i) Hypothalamic Lactation

j) Promotion of Post-Partum Lactation

k) Gynecomastia

l) Conclusion

Chapter 29. Conclusions

Chapter 30. Research Problems


Subject Index


No. of pages:
© Butterworth-Heinemann 1970
1st January 1970
eBook ISBN:

About the Author

F. G. Sulman

About the Editors

F. Gross

A. Labhart

T. Mann

Ratings and Reviews