Hypertension, Cardiovascular Disease, Analgesics, and Endocrine Disorders

Hypertension, Cardiovascular Disease, Analgesics, and Endocrine Disorders

1st Edition - January 1, 1981

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  • Editors: Jack Z. Yetiv, Joseph R. Bianchine
  • eBook ISBN: 9781483266503

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Description

Recent Advances in Clinical Therapeutics, Volume 1: Hypertension, Cardiovascular Disease, Analgesics, and Endocrine Disorders presents the clinical development in therapeutics. This book covers three major areas, including endocrinology, analgesics, and hypertension and other cardiovascular risk factors. Organized into four parts encompassing 20 chapters, this volume begins with an overview of the stepped care approach to the treatment of hypertension. This text then summarizes the advances in various fields of medicine, including concepts or principles of pharmacotherapy. Other chapters consider the value of treating mild hypertension and the combined use of sodium nitroprusside and a chronotropic drug in congestive heart failure. This book discusses as well the methods in the therapy of diabetes mellitus. The final chapter deals with the three general approaches by which therapeutic agents are developed, namely, clinical methods, pharmacological methods, and chemical methods. This book is a valuable resource for clinical pharmacologists, primary care physicians, and allied health professionals.

Table of Contents


  • Contributors

    Foreword

    Preface

    I Hypertension, Hyperlipidemia, and Cardiology

    1 Current Concepts in the Treatment of Essential Hypertension

    Introduction

    Step 1

    Step 2

    Step 3

    Step 4

    Summary

    References

    2 New Antihypertensive Drugs

    Introduction

    Prazosin

    Minoxidil

    Combination Therapy

    Summary

    References

    3 Treatment Decisions in Mild Hypertension

    Introduction

    Design of the HDFP Study

    Stepped Care Therapy

    Results of Treatment of Mild Hypertension in the HDFP

    Conclusion

    References

    4 Treatment of Malignant Hypertension and Hypertensive Crisis

    Introduction

    Malignant Hypertension

    Hypertensive Crisis

    Conclusion

    References

    5 Recent Innovations in the Pharmacology of Low-Output Congestive Heart Failure

    Introduction

    Pathophysiological Responses to Ventricular Dysfunction

    Pharmacological Concepts

    Conclusion

    References

    6 Pharmacotherapy of Cardiac Arrhythmia

    Introduction

    General Principles of Antiarrhythmic Therapy

    Methods for Arrhythmia Diagnosis, Treatment, and Assessment of Treatment Efficacy

    Classification of Antiarrhythmic Drugs

    Summary

    References

    7 Update on Protective Lipids

    Introduction

    Risk Factors for Atherosclerosis

    Lipoprotein Nomenclature

    Lipid and Lipoprotein Metabolism

    Pathogenesis of Atherosclerosis

    HDL—The Protective Lipid

    Conclusions

    References

    8 Panel Discussion on Hypertension

    9 Case Presentation and Discussion on Hypertension

    Patient 1

    Patient 2

    Patient 3

    II Endocrinology

    10 Vitamin D and Calcium Metabolism

    Introduction

    Endocrine Control of Calcium Homeostasis

    Renal-Vitamin D Endocrine System

    Clinical Relevance of Vitamin D Endocrine System

    Summary

    References

    11 Management of Postmenopausal Osteoporosis

    Introduction

    Bone Calcium Dynamics

    Differentiation of Osteomalacia from Osteoporosis

    Radiographic Signs of Osteoporosis

    Differential Diagnosis of Postmenopausal Osteoporosis

    Therapy of Osteoporosis

    Summary

    References

    12 Oral Hypoglycemics

    Introduction

    Historical Background of the Sulfonylureas

    First-Generation Sulfonylureas

    Second-Generation Sulfonylureas

    Conclusion

    References

    13 Recent Advances in Diabetes Research and Therapy

    Introduction

    New Diagnostic Criteria and Reclassification

    The UGDP Study

    Etiology of Diabetes

    Determinants of Diabetic Control

    Assessment of Diabetic Control

    Review of Conventional and New Therapeutic Maneuvers in the Treatment of Diabetes Mellitus

    Conclusion

    References

    14 New Dopamine Agonists in the Treatment of Hyperprolactinemia and Acromegaly

    Introduction

    History

    Hyperprolactinemia

    Dopamine Receptor Agonists

    Bromocriptine

    Conclusions

    References

    15 Panel Discussion on Osteoporosis

    III Analgesics

    16 Pharmacological and Other Effects of Opiate Agonists and Antagonists

    Introduction

    Pain

    Opiate Agonists and Antagonists

    Endogenous Opiate Peptides: Enkephalins and Endorphins

    Conclusions

    References

    17 Narcotics in Myocardial Infarction

    Introduction

    Administration of Narcotics

    Hemodynamic Effects of Morphine, Meperidine, Pentazocine, and Nalbuphine

    Side Effects

    Summary

    References

    18 Treatment of Rheumatoid Arthritis

    Introduction

    Influence of Pathogenesis on Treatment

    Analgesic and Anti-Inflammatory Medications

    Attempts to Induce Remission

    Other Compounds and Procedures

    Surgery

    Physical Therapy and Rehabilitation

    Conclusion

    References

    IV Miscellaneous

    19 Management of Anaphylaxis

    Introduction

    Etiology

    Pathogenesis

    Clinical Manifestations

    Pathological Findings

    Differential Diagnosis

    Treatment

    Prevention

    Summary

    References

    20 Rational, Serendipitous, and Other Means of Drug Development

    Introduction

    Chemical Methods

    Pharmacological Methods

    Clinical Trial Methods

    Summary

    References

    Index


Product details

  • No. of pages: 284
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: January 1, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9781483266503

About the Editors

Jack Z. Yetiv

Joseph R. Bianchine

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