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Hypercalcemia, An Issue of Endocrinology and Metabolism Clinics of North America
- 1st Edition, Volume 50-4 - November 15, 2021
- Editors: Claudio Marcocci, Filomena Cetani
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 1 3 2 5 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 1 3 2 6 - 6
Purchase options
Institutional subscription on ScienceDirect
Request a sales quote- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Foreword
- Preface
- Physiology of Calcium Homeostasis: An Overview
- Key points
- Introduction
- Basic aspects of calcium homeostasis
- Endocrine control of calcium homeostasis
- Receptor-mediated regulation of calcium balance in target tissue
- The gastrointestinal-bone-renal axis
- Summary
- Clinics care points
- Pathophysiology of Hypercalcemia
- Key points
- Introduction and physiologic regulation of extracellular calcium
- Pathophysiology of hypercalcemia in clinical disorders
- Summary
- Clinics care points
- Acknowledgments
- Sporadic Primary Hyperparathyroidism
- Key points
- Introduction
- Epidemiology
- Genetic abnormalities
- Clinical presentation
- Diagnosis
- Treatment
- Summary
- Clinics care points
- Nontraditional Aspects of Sporadic Primary Hyperparathyroidism
- Key points
- Introduction
- Cardiovascular disease
- Neurologic, psychological, and cognitive features
- Other systemic involvement
- Unusual presentations
- Summary
- Clinics care points
- Tertiary and Postrenal Transplantation Hyperparathyroidism
- Key points
- Introduction
- Prevalence and casual factors of parathormone anomalies after kidney transplantation
- Clinical impact of parathormone disorders in patients who have undergone kidney transplantation
- Biochemical and instrumental evaluation of parathormone disorders in patients who have undergone kidney transplantation
- Therapeutic management
- Summary
- Clinics care points
- Hereditary Primary Hyperparathyroidism
- Key points
- Introduction
- Clinical evaluation: identification of patients with hereditary primary hyperparathyroidism
- Hereditary causes of primary hyperparathyroidism
- Nonsyndromic familial primary hyperparathyroidism
- Genetic testing workflow
- Summary
- Clinics care points
- Funding statement
- Parathyroid Carcinoma and Ectopic Secretion of Parathyroid hormone
- Key points
- Introduction
- Parathyroid carcinoma
- Ectopic secretion of parathyroid hormone
- Clinics care points
- Disclosure
- Acknowledgments
- Endocrine Disorders with Parathyroid Hormone-Independent Hypercalcemia
- Key points
- Introduction
- Hyperthyroidism
- Hypothyroidism
- Cortisol
- Pheochromocytoma
- Vasoactive intestinal polypeptide
- Growth hormone
- Gonadal dysfunction
- Hyperprolactinemia
- Diabetes
- Discussion
- Summary
- Clinics care points
- Hypercalcemia of Malignancy
- Key points
- Introduction
- Clinical vignette
- Definition and presentation of hypercalcemia of malignancy
- Pathophysiology of hypercalcemia of malignancy
- Diagnostic approach
- Treatment strategies
- Summary
- Clinics care points
- Vitamin D–dependent Hypercalcemia
- Key points
- Vitamin D metabolism
- Hypercalcemic states involving Altered Vitamin D metabolism
- Idiopathic Infantile Hypercalcemia due to Mutations of SLC34A1/NaPi Cotransporter 2A
- Therapeutic approaches to vitamin D–mediated hypercalcemia
- Clinics care points
- Drug-Related Hypercalcemia
- Key points
- Introduction
- Clinics care points
- Hypercalcemia in Pregnancy
- Key points
- Introduction
- Physiology of calcium metabolism during euparathyroid pregnancy
- Causes of hypercalcemia in pregnancy
- Clinical presentation and maternal–fetal complications of hypercalcemia
- Assessment
- Management
- Summary
- Clinics care points
- Rare Causes of Hypercalcemia
- Key points
- Introduction
- Immobilization hypercalcemia
- Hypercalcemia caused by heritable diseases in children
- Cosmetic hypercalcemia
- Milk-alkali syndrome
- Calcium sulfate beads hypercalcemia
- Manganese intoxication
- Postacute kidney failure hypercalcemia
- Hypercalcemia in Paget’s disease
- Clinics care points
- Treatment of Hypercalcemia of Malignancy
- Key points
- Introduction
- Fluids, lasix, calcitonin
- Bisphosphonates and denosumab
- Parathyroid crisis
- Alternative therapies and research directions
- Clinics care points
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 50-4
- Published: November 15, 2021
- Imprint: Elsevier
- Hardback ISBN: 9780323813259
- eBook ISBN: 9780323813266
CM
Claudio Marcocci
Claudio Marcocci, MD, is Professor of Endocrinology at the Department of Clinical and Experimental Medicine, Director of the Postgraduate School in Endocrinology and Metabolism, University of Pisa and Director of the Endocrine Unit 2, University Hospital of Pisa. Over the years he has combined its clinical appointments with basic, translational and clinical research in the fields of parathyroid and thyroid diseases and vitamin D. Over the last 10 years he has contributed original work on the management of Graves’ orbitopathy, the calcium sensing receptor, clinical aspects of primary hyperparathyroidism and hypoparathyroidism and the molecular mechanisms of parathyroid tumorigenesis. Member of several Scientific Associations: Italian Society of Endocrinology, Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases, European Thyroid Association, American Thyroid Association, Endocrine Society, American Society of Bone and Mineral Research, American Association of Clinical Endocrinologists.
Affiliations and expertise
Professor of Endocrinology, Department of Endocrinology, Metabolism, and Orthopaedics, University of Pisa, Pisa, ItalyFC
Filomena Cetani
Affiliations and expertise
Department of Endocrinology and Metabolism
Section of Endocrinology and Bone Metabolism
University of Pisa, Pisa, Italy