Hybrid Nanomaterials for Drug Delivery

Hybrid Nanomaterials for Drug Delivery

1st Edition - February 2, 2022

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  • Editors: Prashant Kesharwani, N.K. Jain
  • eBook ISBN: 9780323903561
  • Paperback ISBN: 9780323857543

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Description

Hybrid Nanomaterials for Drug Delivery covers a broad range of hybrid nanomaterials and nanocomposites used in drug delivery systems. The book reviews a variety of hybrid nanomaterials and structures, including polymer-lipid, chitosan-based, protein-inorganic, quantum dot hybrids, and more. The strengths, limitations and regulatory aspects of hybrid drug delivery systems are also discussed, allowing readers to make informed decisions when choosing to utilize hybrid nanomaterials. Users will find this to be an exciting and comprehensive look into this emerging area. It will be of particular interest to academics and researchers working in materials science, engineering, biomedical engineering, nanotechnology and pharmaceutical science. Multi nanocarrier-based hybrid systems are an emerging concept in the field of drug delivery that allow researchers to avoid some of the challenges faced when administering drugs, such as low bioavailability, development of drug resistance, toxicities, premature drug release, and therapeutic efficacy.

Key Features

  • Describes the properties, synthesis and application of hybrid nanomaterials for use in drug delivery systems
  • Reviews a variety of hybrid nanomaterials and structures, including dendrimer, silica-based, polymer-metal, nanogel systems, and more
  • Discusses the strengths, limitations and regulatory aspects of hybrid drug delivery systems

Readership

Academics and researchers in materials science, engineering and biomedical engineering. Pharmaceutical scientists

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • List of contributors
  • Preface
  • Acknowledgments
  • Chapter 1. Nanostructures and their associated challenges for drug delivery
  • Abstract
  • 1.1 Introduction
  • 1.2 Types of nanostructures for drug delivery
  • 1.3 The main issues of nano drug delivery challenges
  • 1.4 Conclusions and future perspectives
  • References
  • Chapter 2. Chemical and structural characterization of hybrid delivery systems studied by FTIR, NMR, and SAS techniques
  • Abstract
  • 2.1 Introduction
  • 2.2 Chemical and structural characterization techniques
  • 2.3 Final considerations
  • Acknowledgment
  • References
  • Chapter 3. Applications of hybrid nanocrystals in drug delivery
  • Abstract
  • 3.1 Introduction
  • 3.2 The classification, composition, and characteristics of hybrid nanocrystals
  • 3.3 Preparation methods of hybrid nanocrystals
  • 3.4 Applications of hybrid nanocrystals in different administration routes
  • 3.5 Conclusion
  • Acknowledgments
  • References
  • Chapter 4. Hybrid nanogel systems for drug delivery
  • Abstract
  • 4.1 Introduction
  • 4.2 The development of hybrid nanogels-based systems
  • 4.3 Polymeric NPs-hydrogel nanocomposites
  • 4.4 Metal NPs-hydrogel nanocomposites
  • 4.5 pH responsive hybrid nanogel systems
  • 4.6 Temperature responsive hybrid nanogel systems
  • 4.7 Light-responsive hybrid nanogel systems
  • 4.8 Magnetic-responsive hybrid nanogels systems
  • 4.9 Conclusion and future perspectives
  • References
  • Chapter 5. Polymer–lipid hybrid nanostructures for drug delivery
  • Abstract
  • 5.1 Introduction
  • 5.2 Concept, structure, and mechanism of formation of polymer–lipid hybrid nanostructures
  • 5.3 Types of polymer–lipid hybrid nanostructures
  • 5.4 Preparation methodologies and formulation parameters
  • 5.5 Advances in drug delivery using PLHNs
  • 5.6 Conclusion and perspectives
  • References
  • Chapter 6. Hybrid chitosan-based nanoparticulate systems for drug delivery
  • Abstract
  • 6.1 Introduction
  • 6.2 Preparations of various hybrid chitosan
  • 6.3 Hybrid chitosan for oral delivery
  • 6.4 Hybrid chitosan for ocular delivery
  • 6.5 Hybrid chitosan for pulmonary delivery
  • 6.6 Applications of hybrid chitosan
  • 6.7 Conclusion and future perspective
  • Acknowledgment
  • References
  • Chapter 7. Hybrid polymer−metal composites for drug delivery
  • Abstract
  • 7.1 Introduction
  • 7.2 Preparation methods of hybrid structures
  • 7.3 Properties of hybrid structures
  • 7.4 Potential application
  • 7.5 Future prospective and conclusion
  • References
  • Chapter 8. Hybrid protein-inorganic nanoparticles for drug delivery in cancer therapy
  • Abstract
  • 8.1 Introduction
  • 8.2 Hybridization strategies
  • 8.3 Drug loading
  • 8.4 Protein corona
  • 8.5 Impacts of protein functionalization
  • 8.6 Pharmaceutical applications of hybrid protein-inorganic nanoparticles
  • 8.7 Conclusion
  • References
  • Chapter 9. Silica−polymer hybrid nanoparticles for drug delivery and bioimaging
  • Abstract
  • 9.1 Introduction
  • 9.2 Surface modification of silica with polymers
  • 9.3 Silica−polymer or silica−protein hybrid nanoparticles as diagnostics
  • 9.4 Silica-polymer or protein hybrid nanoparticles as theranostics
  • 9.5 Silica-polymer/protein hybrid nanoparticles as therapeutics
  • 9.6 Conclusion
  • Acknowledgment
  • Conflict of interest
  • References
  • Chapter 10. Dendrimer nanohybrid systems for drug delivery
  • Abstract
  • 10.1 Introduction
  • 10.2 Dendrimers-based nanohybrid techniques
  • 10.3 Advantages of dendrimer-based nanohybrids
  • 10.4 Conclusion
  • References
  • Chapter 11. Bioactive hybrid nanowires for drug delivery
  • Abstract
  • 11.1 Introduction
  • 11.2 General properties of nanowires
  • 11.3 Types of nanowires
  • 11.4 Production methods for nanowires
  • 11.5 Surface functionalization of nanowires (hybrid nanowires for biomaterials)
  • 11.6 Bioapplications of nanowires
  • 11.7 Toxicity of nanowires
  • 11.8 Conclusions and future prospects
  • References
  • Chapter 12. Polymers and polymeric hybrids for targeted drug delivery
  • Abstract
  • 12.1 Introduction
  • 12.2 Principle for the design of anticancer nanomedicine
  • 12.3 Polymers, polymeric conjugates, and polymeric micelles
  • 12.4 Conclusions
  • References
  • Chapter 13. Quantum dots hybrid systems for drug delivery
  • Abstract
  • 13.1 Introduction
  • 13.2 Types of quantum dots
  • 13.3 Synthesis of quantum dots
  • 13.4 Surface modifications of quantum dots
  • 13.5 Hybrid quantum dots for drug delivery
  • 13.6 Conclusions
  • Acknowledgment
  • Competing interests
  • References
  • Chapter 14. Strengths, limitations, and regulatory aspects of hybrid drug delivery systems
  • Abstract
  • 14.1 Introduction
  • 14.2 Application/strength of hybrid drug delivery system
  • 14.3 Hybrid drug delivery system as regulatory perspective
  • 14.4 Requirement for hybrid drug marketing approvals
  • 14.5 Hybrid pharmaceutical drugs
  • 14.6 Few drugs that are appropriate for hybrid or 505(b)(2) mechanisms
  • 14.7 Hybrid or 505(b)(2) versus generics
  • 14.8 Selection criteria for drug candidate and hybrid system
  • 14.9 Conclusion and future prospects
  • References
  • Chapter 15. Recent advances and future prospective of hybrid drug delivery systems
  • Abstract
  • 15.1 Introduction
  • 15.2 Importance of different hybrid system for drug delivery
  • 15.3 Hybrid system to treat cancer
  • 15.4 Recent development in hybrid drug delivery system
  • 15.5 Conclusion
  • Acknowledgment
  • References
  • Index

Product details

  • No. of pages: 406
  • Language: English
  • Copyright: © Woodhead Publishing 2022
  • Published: February 2, 2022
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9780323903561
  • Paperback ISBN: 9780323857543

About the Editors

Prashant Kesharwani

Dr Kesharwani has more than 200 international publications in well reputed journals and 13 published books (Elsevier). He is a recipient of several internationally acclaimed awards viz ‘Ramanujan Fellowship, DST, India-2017’, ‘Excellence Research Award 2014’, ‘Young Innovator Award (Gold medal) 2012’, ‘International Travel Award/Grant from DST (New Delhi) and INSA (CCSTDS, Chennai) 2012’. He has received an ICMR Senior Research Fellowship (PhD) and AICTE Junior Research Fellowship (M. Pharm). He has presented many invited talks and oral presentations at prestigious scientific peer-conferences, received international acclaims and awards for research contribution, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of wider community. An overarching goal of his current research is the development of nano-engineered drug delivery systems for various diseases, including cancer.

Affiliations and Expertise

Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

N.K. Jain

Prof. N.K. Jain is an internationally renowned academician and researcher and a senior professor in India who superannuated in June 2014 after rendering more than 40 years of dedicated and distinguished service as a teacher and 25 years as full professor. Prof. Jain is the author of two dozen celebrated books in pharmaceutical sciences in India and has contributed several chapters in national and international books. He has to his credit over 480 publications in reputed pharmaceutical Journals and has supervised 55 PhD and 141 M. Pharm. candidates. He has been a reviewer for several international and national research journals. Professor Jain’s current research interests include various aspects of controlled, novel and targeted drug delivery; nanotechnology and nanomedicine and he is globally known for his excellent research in the field of hydrotropic solubilization, resealed erythrocytes-based drug delivery and dendrimer drug delivery. Currently he is exploring the pharmaceutical potential of Carbon Nanotubes and Quantum Dots. Recently he has also contributed two chapters on international books.

Affiliations and Expertise

Internationally Renowned Academician, Researcher and a Senior Professor, India

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