Humoral Control of Growth And Differentiation

Humoral Control of Growth And Differentiation

Vertebrate Regulatory Factors

1st Edition - January 1, 1973

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  • Editor: Joseph Lobue
  • eBook ISBN: 9780323150781

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Humoral Control of Growth and Differentiation, Volume I: Vertebrate Regulatory Factors is a part of two-volume work that introduces the reader to humoral control of growth and differentiation in vertebrates. This volume gives emphasis on chemical messengers, which have received relatively little attention in standard treatises on endocrine physiology for a number of reasons. Organized into three parts, this book begins with the physiological significance of chalones. This class of hormones is intimately associated with mitotic homeostasis as inhibitors of cell division. The book then looks into the aspects of blood cell formation and release, as well as the humoral control of organs and tissue growth. This volume also includes chapters discussing the humoral changes occurring in diseases of the blood and other pathologic states. The humoral factors influencing lymphocyte proliferation in culture are also explained. Moreover, this volume examines the effects of the more orthodox hormones upon skeletal growth and regeneration.

Table of Contents

  • List of Contributors


    Contents of Volume II

    I Chalones

    1. Chalone Control Systems

    I. Introduction

    II. Mitotic Control: Positive Feedback

    III. Mitotic Control: Negative Feedback

    IV. Mitotic Control in Epidermis

    V. Epidermal Chalone and Stress Hormones

    VI. Other Chalone Systems

    VII. Characteristics of Chalones

    VIII. The Chalone Mechanism

    IX. The Epidermal Response to the Epidermal Chalone

    X. Wound Healing and Tissue Regeneration

    XI. Carcinomata

    XII. The Pattern of Tumor Growth

    XIII. General Conclusions


    II Blood Cell Formation and Release

    2. Erythropoietin: The Humoral Regulator of Erythropoiesis

    I. Introduction

    II. Erythropoietin

    III. General Conclusions


    3. Humoral Regulation of Neutrophil Production and Release

    I. Historical Background

    II. Stem Cells

    III. Proliferation and Maturation of Neutrophils

    IV. Cellular and Humoral Regulation of Neutrophil Release

    V. Regulation within the Circulation

    VI. Regulatory Events in an Inflammatory Reaction

    VII. Possible Mechanisms Regulating Neutrophil Production and Release

    VIII. Problems to Be Resolved


    4. Humoral Regulation of Eosinophil Production and Release

    I. Introduction

    II. Eosinapheresis as a Methodological Approach for the Study of the Control of Eosinophil Production

    III. The Humoral Control of Leukopoiesis: General Mechanisms and Some Speculations on Factors Controlling Eosinopoiesis

    IV. Summary


    5. The Colony Stimulating Factor (CSF)

    I. Granulocytic and Macrophage Colony Formation

    II. Nature and Origin of Colony Stimulating Factor

    III. Mechanism of Action of CSF in Vitro

    IV. Origin and Metabolism of CSF

    V. Effects of CSF in Vivo

    VI. Summary


    6. Humoral Regulation of Thrombocytopoiesis

    I. Introduction

    II. Alterations in Thrombocytopoiesis under Changing Demands for Circulating Platelets

    III. Thrombopoietin and Its Assay

    IV. Mode of Action of Thrombopoietin

    V. Regulation of Termination of DNA Synthesis

    VI. Summary


    7. Humoral Aspects of Blood Cell Dyscrasias

    I. Introduction

    II. Humoral Aspects of Erythropoiesis

    III. Humoral Aspects of Thrombocytopoiesis

    IV. Humoral Aspects of Leukopoiesis

    V. Conclusions


    8. Regulation of Erythopoiesis in Lower Vertebrates

    I. Introduction

    II. Studies in Frogs

    III. Studies in Birds

    IV. Studies in Fish

    V. Species and Class Specificity of Mammalian and Submammalian Ep

    VI. Comments and Conclusions


    9. Humoral Regulation of Lymphocyte Growth in Vitro

    I. Introduction

    II. Soluble Activities Derived from Leukocytes Stimulating or Potentiating Lymphocyte Growth in Vitro

    III. Factors Involved in Lymphocyte-Macrophage Interaction

    IV. Soluble Activities Present in the Culture Environment Stimulating or Potentiating Lymphocyte Growth in Vitro

    V. Biological Significance of Different Stimulating or Potentiating Activities

    VI. Soluble Substances Derived from Leukocytes Inhibiting Lymphocyte Growth in Vitro

    VII. Soluble Substances Present in the Culture Environment Inhibiting Lymphocyte Growth in Vitro

    VIII. Studies on Growth Modifying Agents in Different Diseases

    IX. Conclusion


    10. Possible Feedback Inhibition of Leukemic Cell Growth: Kinetics of Shay Chloroleukemia Grown in Diffusion Chambers and Intraperitoneally in Rodents

    I. Introduction

    II. Materials and Methods

    III. Results

    IV. Discussion

    V. Summary


    III Humoral Control of Organs and Tissue Growth

    11. The Nerve Growth Factor

    I. Introduction

    II. Structural Properties of NGF

    III. Distribution of NGF

    IV. Biological Properties of NGF

    V. Immunosympathectomy

    VI. Metabolic Effects of NGF

    VII. Concluding Remarks


    12. Humoral Aspects of Liver Regeneration

    I. Introduction

    II. Experimental Results

    III. Conclusion


    13. Renal Growth Factor

    I. Introduction

    II. Denervated, Transplanted Kidney

    III. Kidneys in Vascular Parabiosis

    IV. Problems in Assays

    V. Transfer of Serum

    VI. Tissue Extracts

    VII. Growth Regulators versus Work Hypertrophy

    VIII. Search for the Factor

    IX. Summary


    14. Hormonal Influence on Skeletal Growth and Regeneration

    I. Introduction

    II. The Hierarchy of Skeletal Cell Compartments

    III. Somatotropic Hormone (Growth Hormone, STH)

    IV. Thyroid Hormone

    V. Androgens and Gonadotropins

    VI. Estrogens and Progestogens

    VII. Adrenocorticotropic Hormone (ACTH) and Adrenocortical Hormones

    VIII. Insulin

    IX. Parathyroid Hormone (PTH)

    X. Thyrocalcitonin (Calcitonin, TCT)

    XI. Parotin

    XII. Summary


    15. Trauma and Tumor Growth with Special Emphasis on Wound Stress and "Wound Hormones"

    I. Introduction

    II. Long-Term Effects of Trauma on Tumor Induction

    III. Immediate Effects of Trauma on Tumor Growth in Experimental Animals

    IV. Effect of Cell and Wound Tissue Factors

    V. Wound Hormones

    VI. The Effect of Stress on Metastases

    VII. Endocrine Effects of Trauma

    VIII. Other Effects of Stress on Cell Proliferation

    IX. Summary


    16. General Summary

    Author Index

    Subject Index

Product details

  • No. of pages: 428
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9780323150781

About the Editor

Joseph Lobue

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