Human Toxicology of Chemical Mixtures

Human Toxicology of Chemical Mixtures

Toxic Consequences Beyond the Impact of One-Component Product and Environmental Exposures

1st Edition - June 18, 2008

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  • Author: Harold Zeliger
  • eBook ISBN: 9780815519843

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This book considers how exposure to toxic mixtures affects the different physiological systems and organs, including the respiratory, cardiovascular, immunological, musculoskeletal, nervous and reproductive systems, as well as the various organs, including the kidneys, liver and skin.The author evaluates various sources of exposure, including air, water, and soil pollution; in utero exposure; chemicals contained in foods, cosmetics, and domestic cleaning products; adhesives and paints; industrial chemicals; pesticides; electromagnetic radiation; and chemicals ingested or inhaled during the use of alcohol, tobacco and narcotics.The book also examines the interplay between exposure to these mixtures and the prevalence of various diseases and conditions, including autism, attention deficit hyperactivity disorder (ADHD), developmental neurotoxicology, multiple chemical sensitivity (MSC), chronic fatigue syndrome (CFS), fibromyalgia (FM), Gulf war syndrome, cancer and cancer clusters. The author also discusses how exposure to these mixtures yields the above diseases and conditions in different populations: fetuses, infants, pre-adolescent children, adolescents and adults.Finally, the book addresses the profound policy implications for formulation, labeling and use of chemical products, and it proposes more stringent exposure limits and warning requirements in light of the newly recognized toxic effects that are directly attributable to the mixture of toxic lipophilic and hydrophilic chemicals.

Key Features

* Addresses chemical mixtures, while most literature only deals with single chemicals exposure.
* Explains why certain toxicological effects are observed.
* Discusses diagnosis and treatment of injuries resulting from exposure.
* Explores consequences of effects on product formulation, use, handling and required warnings.
* Provides guidelines for safer development of personal care, cosmetic, industrial and consumer use products.


Toxicologists, medical practitioners, industrial hygienists, safety personnel, chemical formulators in the chemical, personal care, cosmetic, pharmaceutical, industrial, and consumer chemical product industries. Other segments include food manufacturers, laboratory workers, environmental and OSHA training personnel, forensic investigators and attorneys involved in toxic torts litigation.

Table of Contents

  • PART I Introduction to Chemical Toxicology of Mixtures
    Health Effects of Exposures to Chemical Mixtures
    Absorption of Chemical Mixtures
    Chemical Toxicology
    PART II Exposures to Chemical Mixtures
    Scope and sources of toxic exposures
    In Utero Exposure
    Air Pollution
    Water Pollution
    Soil Pollution
    Chemicals In and Around The Home
    Sick Building Syndrome
    Industrial Exposure
    Alcohol and Tobacco: Recreational Toxins
    Electromagnetic Radiation and Toxic Exposure
    PART III Mixture Effects on Body Systems
    Respiratory System
    Nervous System
    Developmental Neurotoxicology
    Autism: Effect of Maternal Exposure to Neurotoxic Chemcials
    Attention Deficit Hyperactivity Disorder (ADHD)
    Endocrine System
    Toxic Infertility
    Immune System
    Chemical Sensitivity: Multiple Chemical Sensitivity (MCS)
    Musculoskeletal System
    Cardiovascular System
    Childhood Cancer
    Cancer Clusters
    Regulatory Requirements

Product details

  • No. of pages: 400
  • Language: English
  • Copyright: © William Andrew 2008
  • Published: June 18, 2008
  • Imprint: William Andrew
  • eBook ISBN: 9780815519843

About the Author

Harold Zeliger

Dr. Harold I. Zeliger holds a PhD in organic chemistry and has been a professor of chemistry and environmental science. He is a Certified Professional Chemist, a Board- Certified Forensic Examiner, and an EPA Certified Laboratory Director. Dr. Zeliger is the author of 51 technical publications, including basic research journal articles and patents. In his more than 40 years in the Chemical Process Industry, he has personally developed many industrial and consumer chemical products, designed chemical product warning labels and written Material Safety Data Sheets for toxic and flammable chemicals. Dr. Zeliger has investigated hundreds of toxic chemical exposures, environmental spills and discharges, chemical fires and explosions nationally and internationally. He has served repeatedly as an expert witness for both plaintiffs and defendants in chemical product, process, toxic exposure, environmental, flammable, intellectual property and subrogation claims. Dr. Zeliger has provided services for numerous forensic examinations, technology transfer and due diligence investigations. Dr. Zeliger’s research is in the area of chemical toxicology. His published work includes papers on the toxic effects of chemical mixtures and chemical causes of cancer clusters and two editions of Human Toxicology of Chemical Mixtures, Second Edition.

Affiliations and Expertise

Toxic and Flammable Chemical Consultant and Expert Witness; Certified Professional Chemist and Board Certified Forensic Examiner; Technology Transfer and Due Diligence Investigator, USA

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