Human Toxicology of Chemical Mixtures

1st Edition

Toxic Consequences Beyond the Impact of One-Component Product and Environmental Exposures

Print ISBN: 9780815515890
eBook ISBN: 9780815519843
Imprint: William Andrew
Published Date: 18th June 2008
Page Count: 400
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This book considers how exposure to toxic mixtures affects the different physiological systems and organs, including the respiratory, cardiovascular, immunological, musculoskeletal, nervous and reproductive systems, as well as the various organs, including the kidneys, liver and skin.

The author evaluates various sources of exposure, including air, water, and soil pollution; in utero exposure; chemicals contained in foods, cosmetics, and domestic cleaning products; adhesives and paints; industrial chemicals; pesticides; electromagnetic radiation; and chemicals ingested or inhaled during the use of alcohol, tobacco and narcotics.

The book also examines the interplay between exposure to these mixtures and the prevalence of various diseases and conditions, including autism, attention deficit hyperactivity disorder (ADHD), developmental neurotoxicology, multiple chemical sensitivity (MSC), chronic fatigue syndrome (CFS), fibromyalgia (FM), Gulf war syndrome, cancer and cancer clusters. The author also discusses how exposure to these mixtures yields the above diseases and conditions in different populations: fetuses, infants, pre-adolescent children, adolescents and adults.

Finally, the book addresses the profound policy implications for formulation, labeling and use of chemical products, and it proposes more stringent exposure limits and warning requirements in light of the newly recognized toxic effects that are directly attributable to the mixture of toxic lipophilic and hydrophilic chemicals.

Key Features

  • Addresses chemical mixtures, while most literature only deals with single chemicals exposure.
  • Explains why certain toxicological effects are observed.
  • Discusses diagnosis and treatment of injuries resulting from exposure.
  • Explores consequences of effects on product formulation, use, handling and required warnings.
  • Provides guidelines for safer development of personal care, cosmetic, industrial and consumer use products.


Toxicologists, medical practitioners, industrial hygienists, safety personnel, chemical formulators in the chemical, personal care, cosmetic, pharmaceutical, industrial, and consumer chemical product industries. Other segments include food manufacturers, laboratory workers, environmental and OSHA training personnel, forensic investigators and attorneys involved in toxic torts litigation.

Table of Contents

PART I Introduction to Chemical Toxicology of Mixtures Introduction Health Effects of Exposures to Chemical Mixtures Absorption of Chemical Mixtures Chemical Toxicology PART II Exposures to Chemical Mixtures Scope and sources of toxic exposures In Utero Exposure Air Pollution Water Pollution Soil Pollution Food Chemicals In and Around The Home Sick Building Syndrome Industrial Exposure Pesticides Alcohol and Tobacco: Recreational Toxins Electromagnetic Radiation and Toxic Exposure PART III Mixture Effects on Body Systems Respiratory System Nervous System Developmental Neurotoxicology Autism: Effect of Maternal Exposure to Neurotoxic Chemcials Attention Deficit Hyperactivity Disorder (ADHD) Endocrine System Toxic Infertility Teratogens Immune System Chemical Sensitivity: Multiple Chemical Sensitivity (MCS) Skin Musculoskeletal System Cardiovascular System Liver Kidneys Cancer Childhood Cancer Cancer Clusters PART IV REGULATORY REQUIREMENTS, CONCLUSIONS Regulatory Requirements Conclusions


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© William Andrew 2008
William Andrew
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"An easy-to-read book that should be in any toxicologist's library. With an enormous effort of synthesis, the author has treated a wide variety of subjects in the emerging field of chemical mixtures." -- Arturo Ortego, M.D., School of Medicine and Health Sciences, Rovira I Virgili University, Reus, Spain