Human Reproductive and Prenatal Genetics - 1st Edition - ISBN: 9780128135709

Human Reproductive and Prenatal Genetics

1st Edition

Editors: Peter Leung Jie Qiao
Paperback ISBN: 9780128135709
Imprint: Academic Press
Published Date: 3rd September 2018
Page Count: 710
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Human Reproductive and Prenatal Genetics presents the latest material from a detailed molecular, cellular and translational perspective. Considering its timeliness and potential international impact, this all-inclusive and authoritative work is ideal for researchers, students, and clinicians worldwide. Currently, there are no comprehensive books covering the field of human reproductive and prenatal genetics. As such, this book aims to be among the largest and most useful references available.

Key Features

  • Features chapter contributions from leading international scientists and clinicians
  • Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization and implantation, in vitro culture of the human embryo for the study of post-implantation development, and more
  • Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics based approaches


Active researchers, basic and translational scientists, clinicians, and students in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, andrology, embryology, endocrinology, bioinformatics, prenatal testing, and genetic testing; genetic counselors; bioethicists; fertility specialists

Table of Contents

Part I. Reproductive Tract Development and Gametogenesis
1. Developmental Genetics of the Male Reproductive System
  Dolores Lamb
2. Genetics and genomics of early gonad development
  Kai Kei Miu, Dan Dan Cao, Gang Lu and Wai Yee Chan
3. Genetic Analysis of Meiotic Chromosome Dynamics and Fertility
  Mary Ann Handel, Travis Kent and Tanmoy Bhattacharyya
4. Aging and Sperm Chromatin Quality
  Bernard Robaire, Anais Noblanc and Heather Fice
5. In Vitro Spermatogenesis from Embryonic Stem Cells
  Qi Zhou
6. Developmental Genetics of the Female Reproductive Tract
  Jose Teixeira and Amanda Patterson
7. Molecular Genetics of Oogenesis
  Jie Qiao
8. Epigenetic Control of Oocyte Development
  Maria M. Vivieros and Rabindranath de la Fuente
9. RNA Binding Protein Networks and Translational Control in Oocytes
  Marco Conti
10. Translational Regulation of Gene Expression During Oogenesis and Pre-Implantation Embryo Development
  Emre U. Seli and Ecem Esencan
11. MicroRNAs in Gametes and Preimplantation Embryos: Clinical Implications
  Allison Tscherner, Leanne Stalker and Jonathan LaMarre

Part II. Embryo Implantation, Placenta Development and Pregnancy
12. Mechanisms of Embryo Implantation and Implantation Failure
  Francesco DeMayo
13. Transcriptomics of the Human Endometrium and Embryo Implantation
  Carlos Simon and Maria Ruiz
14. Maternal Recognition of Pregnancy
  Asgerally T. Fazleabas
15. Human Genetics at the Fetal-Maternal Interface
  Claire Trelford Roberts
16. Epigenetic Modifications in the Human Placenta
  Wendy P. Robinson
17. Micro RNA in the Human Placenta and Pre-eclampsia
  Yan-Ling Wang
18. Genetics and Genomics of Preterm Birth
  Stephen J. Lye, Oksana Shynlova and Lubna Nadeem
19. The Intergenerational Effects on Fetal Programming
  He-Feng Huang

Part III. Infertility and Assisted Reproductive Technology
20. Genetic Testing in Male Infertility
  Alberto Ferlin and Carlo Foresta
21. Genetics and Genomics of Endometriosis
  Linda C. Giudice
22. Genetics and Genomics of Primary Ovarian Insufficiency
  Elena J. Tucker, Sylvie Jaillard and Andrew H. Sinclair
23. Genetics of Polycystic Ovary Syndrome
  Tristan Hardy and Robert J. Norman
24. Genetics and Genomics of Recurrent Pregnancy Loss
  Laura Kasak, Kristiina Rull and Maris Laan
25. Human Genetics and Assisted Reproduction
  Chii-Ruey Tzeng
26. Uterine Transplantation
  Mats Brännström

Part IV. Preimplantation/Prenatal Genetic Diagnosis and Screening
27. Preimplantation Genetic Diagnosis (PGD) and Screening (PGS)
  Alan H. Handyside
28. Molecular Genetics in Preimplantation Diagnosis and Screening
  Joris R. Vermeesch
29. Epidemiology and Genetics of Human Aneuploidy
  Howard Cuckle and Svetlana Arbuzova
30. Next Generation Sequencing for Gene Panels and Clinical Exomes
  Ignatia Barbara Van den Veyver
31. Chromosomal Microarrays and Exome Sequencing for Diagnosis of Fetal Abnormalities
  Brynn Levy
32. Noninvasive Prenatal Testing for Genetic Diseases
  Jason C.H. Tsang and Y.M. Dennis Lo
33. Non-Invasive Prenatal Testing by Cell-Free DNA: Technology, Biology, Clinical Utility and Limitations
  Francesca Romana Grati, Komal Bajaj, Giuseppe Simoni, Federico Maggi, Susan J. Gross and Jose Carlos Pinto B. Ferreira
34. Prenatal diagnosis and treatment of genetic steroid disorders
  Maria I. New and Ahmed A. Khattab
35. Application of Gene-Editing Technologies in Embryos and Their Potential for Gene Therapy
  Cristina Eguizabal, Nuria Montserrat and Juan Carlos Izpisua Belmonte


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Academic Press
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About the Editor

Peter Leung

Dr. Leung is a Professor at the University of British Columbia’s Department of Obstetrics & Gynecology and former Associate Dean in the Faculty of Medicine at UBC. Dr. Leung received his PhD from Western University. After post-doctoral training at the University of California at Los Angeles and the Laval University, he joined the University of British Columbia in 1982 as a faculty member. Dr. Leung has received a number of prestigious awards, including a Scholar Award and a Scientist Award from the Medical Research Council of Canada, a Distinguished Scholar Award from the Michael Smith Foundation for Health Research and a Senior Scientist Award from the BC Children Hospital Research Institute. Dr. Leung has served on many national and international organizations, including as President of the Canadian Fertility and Andrology Society, Director of the Society for the Study of Reproduction, Director of the Ovarian Workshops in the USA, temporary advisor to the World Health Organization, Fellow of the Canadian Academy for Health Sciences, and Fellow of the Royal Society of Canada. Dr. Leung’s research focuses on hormonal determinants of women’s reproductive health. His publication record to date includes 400 papers, 350 abstracts, 22 book chapters and 7 monographs. Since his appointment at UBC, Dr. Leung has served as the research supervisor for more than 100 graduate students, postdoctoral fellows and visiting scientists.

Affiliations and Expertise

Professor, Department of Obstetrics and Gynecology, University of British Columbia, Canada

Jie Qiao

Dr. Jie Qiao is the Chief Scientist of the Ministry of Science and Technology of China, the Incumbent Director of the North Third Hospital Department of Obstetrics and Gynecology, the Chinese Medical Association branch chairman for Reproductive Medicine, and the Beijing Medical Association branch chairman for Reproductive Medicine. She has been engaged in reproductive health-related clinical and basic research throughout her career, including as a visiting scholar at the University of Hong Kong and as a post-doctoral researcher at Stanford University. Her research has focused on gametes fertilization, infertility and embryo implantation mechanisms, and polycystic ovary syndrome pathogenesis among other topics. Dr. Jie Qiao has published more than 250 paper publications in peer reviewed journals on topics related to reproductive health.

Affiliations and Expertise

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Beijing University Third Hospital, Haidian District, Beijing, China

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