Human Prion Diseases

1st Edition, Volume 153 - June 7, 2018
Editors: Maurizio Pocchiari, Jean Manson
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 4 - 6 3 9 4 5 - 5
eBook ISBN:
9 7 8 - 0 - 4 4 4 - 6 3 9 5 3 - 0

Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including… Read more

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Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems.

Maurizio Pocchiari

Professor Maurizio Pocchiari is a neurologist working at the Istituto Superiore di Sanità, Rome, Italy, where chairs the Department of Neuroscience. He heads a group of neurologists, geneticists, biochemists, and statisticians working on various aspects of human and experimental prion diseases. These include studies on clinical and molecular epidemiology, diagnosis, pathogenesis, experimental therapy, biochemistry and molecular and cellular biology of the prion protein and the prion protein gene, development of new techniques for the inactivation of prions, and the analysis of risk in transmitting prions from animal-to-human or from human-to-human. Professor Pocchiari runs the Italian Creutzfeldt-Jakob disease surveillance unit since 1993 and is a member of the Coordination Committee of the European Creutzfeldt-Jakob disease Surveillance Network (EuroCJD) of the European Centre for Disease Prevention and Control (ECDC).

Affiliations and expertise

Professor and Director of Research, Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanita (ISS), Rome, Italy

Jean Manson

Prof. Manson is an internationally recognised leading scientist in TSE research and has developed, delivered and managed a high international scientific programme involving studies of animal and human Transmissible Spongiform Encephalopathies (TSEs). She develops and uses in vivo and in vitro model systems to define the basic mechanisms of disease and to address practical issues involving the TSEs. She heads a division of six group leaders and forty scientific staff all researching TSEs. She also runs a research group of seventeen people, including postdocs, technicians and PhD students.

The transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases affecting humans and animals. TSEs present with characteristic pathology which can include neuronal loss, reactive astrogliosis, deposition of disease-associated prion protein (PrP) and vacuolation in the brain. The aim of her group is to examine the role of host PrP in TSEs such as scrapie, bovine spongiform encephalopathy (BSE) and Creutzfeldt-Jakob disease (CJD), the nature of the infectious and neurotoxic agent and to define routes of transmission between and within animal Basic research into neurodegenerative processes has also led into study of other diseases such as Alzheimer’s disease. They use a variety of models from the molecular to whole animal level of study. They have produced a number of unique transgenic mouse models via gene-targeting and with these models we are investigating the effects of PrP sequence, the species barrier, the influence of PrP glycosylation on disease susceptibility and also the expression of PrP in various cell-types or at specific time-points during disease. The group also investigates human to human transmission of vCJD via blood transfusion and other potential routes. Their research programme currently receives funding from a number of different sources including BBSRC, MRC, DEFRA, DoH and EU.

Affiliations and expertise

Professor and Head, Neurobiology Division, The Roslin Institute, University of Edinburgh, UK