Human Papillomavirus

Human Papillomavirus

Proving and Using a Viral Cause for Cancer

1st Edition - November 23, 2019

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  • Editors: David Jenkins, Xavier Bosch
  • eBook ISBN: 9780128144862
  • Paperback ISBN: 9780128144572

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Human Papillomavirus: Proving and Using a Viral Cause for Cancer presents a steady and massive accumulation of evidence about the role of HPV and prevention of HPV-induced cancer, along with the role and personal commitment of many scientists of different backgrounds in establishing global relevance. This exercise involved years of personal commitment to proving or disproving an idea that aroused initial skepticism, and that still has difficult implications for some. It remains one of the big successes of medicine that exploited both established medical science dating back to the nineteenth century and new molecular genetic science during a time of transition in medicine.

Key Features

  • Presents a comprehensive, up-to-date review of the role of HPV in cancer from those involved in its study
  • Includes the way evidence on the role and utility of HPV based prevention has been accumulated over almost 40 years
  • Gives a series of vignettes of individual scientists involved in the development of the science of HPV and cancer at different stages and their experiences and reasons for involvement


Clinical and scientific virology and cancer research; public health, diagnostic and pharmaceutical industries; modern medical history and sociology. Graduate level scientists in virology, molecular biology, pathology, screening, vaccines and epidemiology and public health

Table of Contents

  • Section 1: Early questions and their slow answers
    1. Introduction: Implications and responses to a possible specific infectious cause for a solid cancer, approaches to proving the role of HPV, and exploring its potential uses against conventional medical practice
    2. Cervical and other cancers now associated with HPV prior to recognition of HPV in cervical cancer
    3. Cervical screening and its basis in ideas of precancer in classical microscopic pathology
    4. The "discovery" of HPV I6 in cervical cancer and studies of its transforming role, P53 and pRB
    5. Growing numbers of carcinogenic papillomaviruses and understanding of their differences
    6. The impact of HPV on conventional morphological pathology of cancer and precancer. Bethesda classification, molecular markers relating morphology to molecular mechanisms
    7. The proof of causality in humans
    8. Progression from infection to cancer
    9. Sexuality and HPV: sexual transmission, male role
    10. Genital warts
    11. HPV and non-cervical cancer
    12. Immune responses, and antibodies to HPV, making viral antigens
    13. Developing and standardising HPV tests
    14. HPV and non-HPV pathways to cancer

    Section 2: Prevention of cancer and HPV infection
    15. Introduction: Evidence-based medicine, HPV and cancer prevention
    16. Triage of women with low-grade smear abnormalities and HPV testing, HC1 and 2, GP5+/6+, ALTS trial, Netherlands, other trials
    17. Primary screening by HPV testing
    18. Prophylactic vaccines, proving their value and the role and limitations of the pharmaceutical industry and its regulators, safety and efficacy
    19. Modelling disease, prevention and cost-effectiveness – a developing process, different types of models, what does cost-effectiveness mean?
    20. Changing global concerns about screening and vaccination

Product details

  • No. of pages: 460
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: November 23, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128144862
  • Paperback ISBN: 9780128144572

About the Editors

David Jenkins

Senior Researcher. Practitioner and author and Emeritus Professor in Pathology, University of Nottingham, UK

Affiliations and Expertise

Emeritus Professor in Pathology, University of Nottingham, UK

Xavier Bosch

Senior Consultant to the Cancer Epidemiology Research Program and Director of International Affairs at the Catatan Institute of Oncology - Director of the e-oncologia - Co-Director of the the IARC / ICO Information Centre on HPV and Cancer, Catalan Institute of Oncology | Cancer Epidemiology Research Program | Granvia de L'Hospitalet 199-203 | 08908 L'Hospitalet de Llobregat (Barcelona, Catalonia, Spain)

Affiliations and Expertise

Senior Consultant, Cancer Epidemiology Research Program and Director of International Affairs, Catatan Institute of Oncology

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