Human-Gut Microbiome

Human-Gut Microbiome

Establishment and Interactions

1st Edition - July 9, 2022

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  • Editors: Gunjan Goel, Teresa Requena, Saurabh Bansal
  • Paperback ISBN: 9780323913133
  • eBook ISBN: 9780323913713

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Description

Human-Gut Microbiome: Establishment and Interactions gives an overview of microbiome establishments in humans and basic technologies used to decipher the structure and function of gut microbiome. Other sections focus on the application of microbiomics in different disease manifestations, such as obesity, diabetes, and more. The book provides the basics, as well as mechanistic knowledge underpinning the structural and functional understanding of the microbiome. With the advancement in omics technologies, as well as the development of bioinformatic tools, much research has been undertaken to decipher the microbiomes of different hosts. This research is generating valuable insights into micro-ecological niches and their impact on humans, hence this new release covers these new insights. The book will be a valuable resource for scientists, researchers, postgraduate and graduate students who are interested in understanding the impact and importance of the omics approach to humans and their microbiomes.

Key Features

  • Provides an overview of the recent developments in meta-omics technologies
  • Serves as a unique reference for healthcare professionals, pursuing research on gut homeostasis, and functional foods, as well as nutritional dietary management
  • Focuses on the application of microbiomics in different disease manifestations, such as obesity, diabetes, and more

Readership

Scientists (academic and industrial), postgraduate students, research Scholars, PhD students and postdocs, medical sectors involved in host-microbiome (pathogen) interactions studies for developing new drug molecules, and the food

Table of Contents

  • Cover
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Section A: Human microbiome: Establishment and functions
  • Chapter 1: An introduction to human gut microbiome
  • Abstract
  • Introduction
  • Human gut microbiota: Structure and composition
  • Early intestinal microbiota colonization
  • Gut microbiota and its impact on host health
  • Gut microbiota and associated diseases
  • Conclusions
  • References
  • Chapter 2: Early colonization of the human gut
  • Abstract
  • Establishment and development of intestinal microbiota in early life
  • Microbiome and reproduction: Is there microbial transmission in utero?
  • The transfer of bacteria from mother to child
  • References
  • Chapter 3: Techniques and challenges in studies related with human gut microbiome
  • Abstract
  • Introduction
  • Early studies of microbiome prior to sequencing
  • First-generation sequencing
  • Next-generation sequencing
  • TGS (single-molecule long read sequencing-SMRT)
  • Bioinformatics
  • Advancements in culturing techniques
  • Multiomics approach in understanding microbe-microbe and host-microbe interaction
  • Conclusion
  • References
  • Chapter 4: Dietary influence on human microbiome
  • Abstract
  • Acknowledgments
  • Introduction
  • Diet is determinant of the intestinal microbiota composition and function
  • Food ingredients accessible to the gut microbiota
  • Mutual interplay of diet, gut microbiota, and health
  • Food additives and the risk of industrialized microbiota
  • Concluding remarks
  • References
  • Chapter 5: Gut microbiome-derived metabolites in host health and diseases
  • Abstract
  • Introduction
  • Gut microbiome-derived metabolites: The basics
  • Short-chain fatty acids: Microbial fermentation
  • Physiological effects of microbial metabolites
  • SCFAs: Mechanisms of action
  • SCFAs in gut immune and inflammatory health
  • SCFAs in cardiometabolic health
  • SCFAs in cognitive and neurodegenerative health
  • Newly discovered gut microbial metabolites
  • Conclusion and prospects
  • References
  • Section B: Gut microbiome in health and diseases
  • Chapter 6: Role of gut microbiome in obesity
  • Abstract
  • Introduction
  • Historical background
  • Gut microbial diversity
  • The Firmicutes to Bacteroidetes ratio
  • The dynamic relationship between obesity and the gut microbiota
  • Other mechanisms underlying the association between the gut microbiome and obesity
  • Factors that influence the composition of the gut flora
  • Modulation of gut flora to treat obesity
  • Future prospects
  • References
  • Chapter 7: Relationship between gut microbiome and diabetes
  • Abstract
  • Introduction
  • Historical background of diabetes and gut microbiome
  • Gut ecosystem
  • Type 2 diabetes and gut microbiome
  • Gestational diabetes and gut microbiome
  • Type-1 diabetes
  • Major events that aid the pathogenesis of diabetes during gut dysbiosis
  • Gut microbiome manipulation for treatment and prevention
  • Effect of metformin on gut ecosystem
  • Effect of insulin on gut ecosystem
  • Future prospects
  • References
  • Web Reference
  • Chapter 8: Human microbiome and neurological disorders
  • Abstract
  • Conflicts of interest/competing interests
  • Introduction
  • Neuropsychiatric disorder
  • Neurodegenerative diseases
  • Autoimmune diseases
  • References
  • Chapter 9: Modulation of gut microbiota by probiotic interventions: A potential approach toward alleviating food allergy
  • Abstract
  • Introduction
  • Gut microbiota and its implications in the development of immune system
  • Gut-dysbiosis and food allergy
  • Gut microbiota and food allergy
  • Effect of food allergens on host immune response
  • Probiotics and their effects in food allergy
  • Conclusion
  • References
  • Chapter 10: Interplay of alpha-synuclein pathology and gut microbiome in Parkinson’s disease
  • Abstract
  • Acknowledgments
  • Introduction
  • Gut microbiota roles and functions
  • Pathological implications of gut microbiota dysbiosis
  • Etiology of Parkinson’s disease and role of alpha-synuclein
  • Gut microbiota alterations and Parkinson’s disease
  • Interplay of αSyn and gut microbiota in inducing Parkinson’s disease
  • Alpha-synuclein in the microbiota-gut-brain axis
  • Utility of alpha-synuclein and the microbiome for diagnosis and treatment of Parkinson’s disease
  • Conclusions and perspectives
  • References
  • Chapter 11: Impact of indigenous microbiota in gut inflammatory disorders
  • Abstract
  • Introduction
  • Indigenous microbiota shifts the way the host responds to inflammatory triggers in the gut
  • Dysbiotic microbiota impacts disease outcome in gut inflammatory disorders
  • Concluding remarks
  • References
  • Chapter 12: Emergence of antibiotic resistance in gut microbiota and its effect on human health
  • Abstract
  • Introduction
  • Microbiota in infections
  • Antimicrobial resistance in gut microbiota
  • Strategies to prevent resistance generation and spread
  • Conclusion
  • References
  • Chapter 13: The gut microbiome in chronic kidney disease
  • Abstract
  • Introduction
  • Gut dysbiosis in chronic kidney disease
  • Uremic toxins and the gut microbiome
  • Inflammation and gut microbiome in CKD: CKD outcomes
  • Strategies for gut microbiome modulation in chronic kidney disease
  • Conclusions
  • References
  • Chapter 14: Fecal microbiota transfer: Basic and clinical aspects, current applications, and future perspectives
  • Abstract
  • Introduction
  • Donor selection
  • Sample collection and processing
  • Recipient preparation
  • Clinical follow-up and engraftment control
  • Current indications
  • Other applications under study
  • Risks and adverse effects
  • Cost-effectiveness
  • Legislation
  • FMT 2.0
  • Conclusions
  • References
  • Chapter 15: Human gut microbiome and psychological disorders
  • Abstract
  • Acknowledgment
  • Gut microbiome (GM) and physical health
  • GM and human psychology
  • References
  • Further reading
  • Chapter 16: Effects of contaminants (heavy metals) on the microbiota status in humans
  • Abstract
  • Introduction
  • Human gut microbiota
  • Modulation of the human gut microbiota
  • Influence of the human gut microbiota on homeostasis of contaminants
  • Effects of contaminants (heavy metals) on human gut microbiota
  • Conclusion
  • References
  • Further reading
  • Index

Product details

  • No. of pages: 328
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 9, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323913133
  • eBook ISBN: 9780323913713

About the Editors

Gunjan Goel

Dr Gunjan Goel is an associate professor at the Department of Microbiology, Central University of Haryana, Mahendergarh, India. He completed his PhD in microbiology at the National Dairy Research Institute, Karnal, India, and did postdoctoral research at the University of Hohenheim, Germany and the University of Ghent, Belgium. He has been working in the area of microbial communities and their assessment and has published more than 70 research papers in journals of international repute. He has been the principal investigator for national and international research projects funded by government agencies. His current research focuses on deciphering the role of different factors affecting gut microbial ecology, bio-accessibility, and bioavailability of food ingredients for in vitro simulated gut-model systems, and the assessment of probiotics using in vitro and in vivo models. He is a life member of the Association of Microbiologists of India and the Probiotic Association of India and he is on the editorial board of Frontiers in Microbiology

Affiliations and Expertise

Associate Professor, Department of Microbiology, Central University of Haryana, Mahendergarh, India

Teresa Requena

Dr Teresa Requena is scientific researcher on the, Spain. She specializes in lactic acid bacteria and modulation of intestinal microbiota by diet, probiotics, and prebiotics. Her recent research achievements relate to the development of in vitro dynamic models of simulation of the human intestinal microbial ecosystem. She has been an invited researcher at the University of Minnesota, USA, and the University of Otago, New Zealand and principal investigator for Spanish and international research projects. Dr Requena has collaborated with commercial companies through research contracts, having broad expertise in patent development and has transferred five patents to food and biotechnology companies. She is author of more than 120 scientific articles published in high-ranked scientific journals, two books, and over twenty book chapters. She is a member of the Board of Directors of the Spanish Society of Microbiota, Probiotics and Prebiotics

Affiliations and Expertise

Spanish National Research Council, at the Institute of Food Science Research, CIAL, Madrid, Spain

Saurabh Bansal

Dr Saurabh Bansal works as an assistant professor in the Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, India. He completed his PhD in biotechnology at the Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Delhi, India. His PhD work involved the cloning, expression, purification, and characterization of the anti-cancer enzyme L-asparaginase from Pyrococcus furiosus, followed by development of their mutants, with improved turnover and catalytic efficiency, using a site-directed mutagenesis approach. Dr Saurabh has a keen interest in the identification of novel enzymes and improving their properties, using protein engineering tools, bio-catalysis, waste management, production optimization using bioprocess technology, and characterization. He has one US Patent. His work has been published in various internationally reputed journals namely, FASEB, Chemico-biological Interactions, Biochimica et Biophysica Acta - Proteins and Proteomics, Acta Crystallographica Section D: Biological Crystallography, and Journal of Molecular Liquids. He is a life member of the Biotech Research Society, India and the Society of Biological Chemists, India

Affiliations and Expertise

Assistant Professor, Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, India

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