Human Chorionic Gonadotropin (hCG)

1st Edition

Authors: Laurence Cole
Hardcover ISBN: 9780123849076
eBook ISBN: 9780123849083
Imprint: Elsevier
Published Date: 21st September 2010
Page Count: 400
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Description

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.

The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.

Key Features

  • It provides comprehensive information on hCG from basic science to clinical medicine

  • Written by specialists in the field

Readership

Researchers and clinicians in obstetrics, gynecology, clinical chemistry, endocrinology, reproductive medicine and oncology

Table of Contents

INTRODUCTION

 Chapter 1: THE EXPANDING WORLD OF hCG

Robert Hussa

Chapter 2: HISTORY AND INTRODUCTION TO HUMAN CHORIONIC GONADOTROPIN (hCG): ONE NAME FOR AT LEAST THREE INDEPENDENT MOLECULES
Laurence Cole

Chapter 3: INTRODUCTION TO PREGNANCY IMPLANTATION, VILLOUS FORMATION, AND HEMOCHORIAL PLACENTATION
Laurence Cole

 GENETICS, SYNTHESIS, SECRETION, STRUCTURE, AND DEGRADATION OF hCG

Chapter 4: THE MOLECULAR GENETICS OF hCG
Stephen Butler

Chapter 5: STRUCTURE, SYNTHESIS, SECRETION, AND FUNCTION OF hCG
Laurence Cole, PhD and Stephen Butler

Chapter 6: COMPARISSON OF STRUCTURES OF hCG AND HYPERGLYCOSYLATED hCG
Laurence Cole

Chapter 7: STRUCTURES OF FREE α-SUBUNIT AND FREE ß-SUBUNIT
Laurence Cole

Chapter 8: GLYCOBIOLOGY OF hCG
Akira Kobata

Chapter 9: DEGRADATION PRODUCTS OF hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT
Laurence Cole

Chapter 10: THE THREE DIMENSIONAL STRUCTURE OF hCG
Laurence Cole

 

BIOLOGICAL FUNCTION OF hCG

Chapter 11: PARADIGM SHIFT ON THE TARGETS OF hCG ACTIONS

CV Rao

Chapter 12: THE hCG RECEPTOR

Laurence Cole and Stephen Butler

Chapter 13: BIOLOGICAL FUNCTIONS OF HYPERGLCOSYLATED hCG
Laurence Cole

Chapter 14: BIOLOGICAL FUNCTION OF THE FREE BETA SUBUNIT: EXPRESSION AND TREATMENT TARGET IN CANCER

Steven Butler and Ray Iles

 

CLINICAL APPLICATIONS

Chapter 15: USE OF hCG IN REPRODUCTIVE DYSFUNCTION
Cisco Byrn

Chapter 16: hCG IN THE IVF CLINIC
Ervin Jones,

Chapter 17: ILLICIT USE OF hCG IN DIETARY PROGRAMS AND USE TO PROMOTE ANABOLISM
Laurence Cole

 

hCG TESTS

C

Details

No. of pages:
400
Language:
English
Copyright:
© Elsevier 2010
Published:
Imprint:
Elsevier
eBook ISBN:
9780123849083
Hardcover ISBN:
9780123849076

About the Author

Laurence Cole

Dr. Cole has served on the journal editorial board from 1994-2001 as the Editor of “Trophoblast Disease Update”. He has written more than 100 articles on hCG structure, physiology and immunoassay and on clinical applications of hCG or hCG-related molecules. He has a 1.17 FWCI in the Medicine category of SciVal where he has published throughout the various disciplines and maintains an average of 12.6 citations per article from 2009-2014. He has experience with international, single, and institutional collaboration. Awards and recognition for Dr. Cole include the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research.

Affiliations and Expertise

Director, USA hCG Reference Service, Santa Fe, New Mexico, USA

Reviews

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.

The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.