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Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.
The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.
It provides comprehensive information on hCG from basic science to clinical medicine
Written by specialists in the field
Researchers and clinicians in obstetrics, gynecology, clinical chemistry, endocrinology, reproductive medicine and oncology
Chapter 1: THE EXPANDING WORLD OF hCG
Chapter 2: HISTORY AND INTRODUCTION TO HUMAN CHORIONIC GONADOTROPIN (hCG): ONE NAME FOR AT LEAST THREE INDEPENDENT MOLECULES
Chapter 3: INTRODUCTION TO PREGNANCY IMPLANTATION, VILLOUS FORMATION, AND HEMOCHORIAL PLACENTATION
GENETICS, SYNTHESIS, SECRETION, STRUCTURE, AND DEGRADATION OF hCG
Chapter 4: THE MOLECULAR GENETICS OF hCG
Chapter 5: STRUCTURE, SYNTHESIS, SECRETION, AND FUNCTION OF hCG
Laurence Cole, PhD and Stephen Butler
Chapter 6: COMPARISSON OF STRUCTURES OF hCG AND HYPERGLYCOSYLATED hCG
Chapter 7: STRUCTURES OF FREE α-SUBUNIT AND FREE ß-SUBUNIT
Chapter 8: GLYCOBIOLOGY OF hCG
Chapter 9: DEGRADATION PRODUCTS OF hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT
Chapter 10: THE THREE DIMENSIONAL STRUCTURE OF hCG
BIOLOGICAL FUNCTION OF hCG
Chapter 11: PARADIGM SHIFT ON THE TARGETS OF hCG ACTIONS
Chapter 12: THE hCG RECEPTOR
Laurence Cole and Stephen Butler
Chapter 13: BIOLOGICAL FUNCTIONS OF HYPERGLCOSYLATED hCG
Chapter 14: BIOLOGICAL FUNCTION OF THE FREE BETA SUBUNIT: EXPRESSION AND TREATMENT TARGET IN CANCER
Steven Butler and Ray Iles
Chapter 15: USE OF hCG IN REPRODUCTIVE DYSFUNCTION
Chapter 16: hCG IN THE IVF CLINIC
Chapter 18: ANTIBODYS FOR INTACT hCG, TOTAL hCG, FREE SUBUNITS, GLYCOSYLATION VARIANTS, AND hCG FRAGMENTS
Chapter 19: QUANTITATIVE hCG ASSAYS
Chapter 20: FALSE-POSITIVE hCG ASSAYS
Chapter 21: SPECIFICITY OF DIFFERENT hCG ASSAYS
Chapter 22: POINT-OF-CARE PREGNANCY TESTS
Laurence Cole Chapter 24: hCG STANDARDS
Chapter 25: BACKGROUND hCG
Chapter 27: PREDICTING SPONTANEOUSLY ABORTED (SAB) PREGNANCIES
Chapter 28: hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT IN PREDICTING DOWN SYNDROME PREGNANCIES AND PREECLAMPSIA
Chapter 29: hCG IN MONITORING GESTATIONAL TROPHOBLASTIC DISEASES
Chapter 30: USE OF HYPERGLYCOSYLATED hCG AS A UNIQUE MARKER OF GESTATIONAL TROPHOBLASTIC NEOPLASMS
Laurence Cole and Carolyn Muller
Chapter 31: PITUITARY hCG AND FAMILIAL hCG
Chapter 33: hCG AND HYPERGLYCOSYLATED HCG PURIFICATION FROM SERUM, URINE, AND CULTURE FLUIDS
Chapter 34: DISSOCIATION, DESIALYLATION, AND CLEAVAGE OF HCG
Chapter 35: hCG AND FREE ß-SUBUNIT PRODUCING CELL LINES
EVOLUTION, SUMMARY AND THE FUTURE
Chapter 36: EVOLUTION OF hCG, EVOLUTION OF HUMANS, EVOLUTION OF HUMAN PREGNANCY DISORDERS AND CANCER
Chapter 37: SUMMARY: hCG A REMARKABLE MOLECULE
Chapter 38: hCG AND THE FUTURE
- No. of pages:
- © Elsevier 2010
- 21st September 2010
- eBook ISBN:
- Hardcover ISBN:
Dr. Cole has served on the journal editorial board from 1994-2001 as the Editor of "Trophoblast Disease Update". He has written more than 100 articles on hCG structure, physiology and immunoassay and on clinical applications of hCG or hCG-related molecules. He has a 1.17 FWCI in the Medicine category of SciVal where he has published throughout the various disciplines and maintains an average of 12.6 citations per article from 2009-2014. He has experience with international, single, and institutional collaboration. Awards and recognition for Dr. Cole include the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research.
Director, USA hCG Reference Service, Santa Fe, New Mexico, USA
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