Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases

1st Edition - December 3, 2021

Write a review

  • Author: Anil Gupta
  • eBook ISBN: 9780128204436
  • Paperback ISBN: 9780128201220

Purchase options

Purchase options
DRM-free (EPub, PDF)
Available
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology.

Key Features

  • Provides in-depth knowledge about neurotoxic potential of transition metals, impaired mitochondrial dynamics in the brain neurons, mutant proteins Aβ peptide, tau protein, α-synuclein, huntingtin protein and formation of Lewy bodies, reactive oxygen and nitrogen species, ubiquitin proteasome dysregulation, and many others in neurodegenerative diseases
  • Elucidates neurogenetics of gene APP, gene PSEN1, gene APOE, gene LRRK2, gene DJ1, and others in the pathology of neurodegenerative diseases
  • Explains caspases-mediated neuronal apoptosis in pathogenesis of Alzheimer’s disease covering amyloidogenesis, caspase-activated DNase, rho-associated coiled coil–containing protein kinase 1, mammalian sterile 20-like kinase 1, role of synaptic loss, microglial TREM2 receptor, microglial LRP1 receptor, microglial advanced glycation end-product receptor, astrocytic glial α 7 subtypes of nAChR, NLRP3 inflammasome, P2X purinoreceptors, miRNAs, and many other factors
  • Demonstrates the role of caspases and apoptosis in Parkinson’s disease covering truncation of α-synuclein, neuroinflammation, parkin protein, activation of microglial cells, extrinsic and intrinsic pathways of apoptosis, Δtau314, and several other factors
  • Explains etiopathogenesis of Huntington’s disease through covering clinically important topics as role of exon 1 HTT protein, ubiquitous nature of huntingtin, length of expanded polyglutamine tract, classically and alternately activated microglia, nuclear factor kappa B, kynurenine signaling pathway, tumor suppressor protein, PGC-1α gene, advanced glycation end-products, autophagy, and many other significant topics

Readership

Biomedical researchers, graduate students, and scientists, as well as neuroscientist and student trainees

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Preface to first edition of book
  • Acknowledgment
  • Chapter 1. Neurodegenerative diseases
  • Introduction
  • Risk factors and neuropathology of neurodegenerative diseases
  • Genetics of neurodegenerative diseases
  • Epidemiology of neurodegenerative diseases
  • Conclusion
  • Chapter 2. Role of caspases, apoptosis and additional factors in pathology of Alzheimer's disease
  • Introduction
  • Amyloid cascade hypothesis in Alzheimer's disease
  • Role of apoptosis in the neuronal death in Alzheimer's disease: a possibility
  • Role of caspases in apoptotic neuronal-death in Alzheimer's disease
  • Role of synaptic loss in Alzheimer's disease
  • Role of microglia in the pathogenesis of Alzheimer's disease
  • Microglial TREM2 receptor in Alzheimer's disease
  • Microglial LRP1 receptor in Alzheimer's disease
  • Microglial advanced glycation end-product receptor in Alzheimer's disease
  • Microglial Fc γ receptors in Alzheimer's disease
  • Microglial CD36 transmembrane protein in Alzheimer's disease
  • Astrocytic glial α 7 subtype of nAChR (α7nAChRs) in Alzheimer's disease
  • Astrocytic glial calcium-sensing receptor in Alzheimer's disease
  • Microglia-τ interaction in Alzheimer's disease
  • Microglial PU.1 transcription factor in Alzheimer's disease
  • TLR4 (toll-like receptor)-mediated signaling pathway in Alzheimer's disease
  • Inflammasome-mediated signaling pathways in Alzheimer's disease
  • Pathway of activation of NLRP3 inflammasome in microglial cell
  • Role of P2X purinoreceptors in Alzheimer's disease
  • Role of P2X7 receptor in activation of inflammasome in Alzheimer’s disease
  • Role of P2X7 purinoreceptor in oxidative stress and Alzheimer's disease
  • Role of upregulated expression of P2X7 receptor in Alzheimer's disease
  • Role of P2X7 purinoreceptor and amyloidogenic processing of APP in Alzheimer's disease
  • Role of chronic psychological stress and Alzheimer's disease
  • Role of microRNAs (miRNAs) in Alzheimer's disease
  • Conclusion
  • Chapter 3. Role of caspases and apoptosis in Parkinson's disease
  • Introduction
  • Role of caspase 1 in pathology of Parkinson's disease
  • Role of caspase 3 in pathology of Parkinson's disease
  • Role of caspase 8 in pathology of Parkinson's disease
  • Role of apoptosis in Parkinson's disease
  • Role of caspase 2 in the pathology of Parkinson's disease
  • Chapter 4. Illustrated etiopathogenesis of Huntington's disease
  • Introduction
  • Structure of Huntingtin
  • Ubiquitous nature of Huntingtin
  • Mutated huntingtin in Huntington disease
  • Pathogenic role of exon 1 HTT protein
  • Clinical relevance of length of expanded polyglutamine tract
  • Introduction to etiopathogenesis of Huntington' disease
  • Microglia activation in pathology of Huntington's disease
  • Role of caspase 2 activation in Huntington disease
  • Oxidative stress, mitochondrial dysfunction and Huntington's disease
  • Advanced glycation end-products in pathology of Huntington disease
  • Role of autophagy in pathology of Huntington's disease
  • Ubiquitin proteasome functioning in Huntington's disease
  • Ubiquitin proteasome functioning is impaired in Huntington disease
  • Index

Product details

  • No. of pages: 242
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: December 3, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128204436
  • Paperback ISBN: 9780128201220

About the Author

Anil Gupta

Prof. (Dr.) Anil Gupta, (D. Sc), Ph.D., M.Sc., B.D.S B.Sc has more than 14 years of teaching experience, 7 years of postdoctoral research experience, and 8 years of PhD supervisor experience, and 25 years of clinical experience. His research interests are in distinctive fields as heavy metals contamination and quality of drinking water, predisposition of blood groups to diabetes mellitus and dyslipidemia, nutritional status of preschool children, habit of geophagia, neurodegenerative diseases, and insulin resistance. He has been an examiner to PhD scholars and dental undergraduates. He is serving as a reviewer and editorial board member in multidisciplinary journals.

Affiliations and Expertise

Former-Dean Research, Professor and Head Department of Biochemistry, Desh Bhagat University, Punjab, India

Ratings and Reviews

Write a review

Latest reviews

(Total rating for all reviews)

  • Deeksha Sun Apr 24 2022

    Review

    Conplete in all aspects..