Human Brain Proteome

Human Brain Proteome

1st Edition - October 13, 2004

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  • Editor: Lisa A. Neuhold
  • eBook ISBN: 9780080522463

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Description

Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer’s disease, alcoholism, trauma/stroke, Huntington's disease, and Parkinson's disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic.

Key Features

* Describes the latest databases and techniques for analyzing the data generated by proteomics
* Outlines the latest developments in proteomic methods
* Provides numerous color illustrations highlighting the application of proteomics to the identification of novel drug targets and biomarkers

Readership

Researchers in academia and industry interested in neuroscience, neurology, molecular biology, and biochemistry, as well as senior undergraduate and graduate students studying these disciplines.

Table of Contents

  • Section I:
    High-Throughput Technologies
    Biomarker Discovery Using Molecular Profiling Approaches
    Proteomic Analysis of Mitochondrial Proteins
    Section II:
    Proteomic Applications
    NMDA Receptors, Neural Pathways and Protein Interaction Databases
    Dopamine Transporter Networks and Pathways
    Proteomic Approaches in Drug Discovery and Development
    Section III:
    Informatics
    Proteomic Informatics
    Proteomics Analysis in Alzheimer's Disease: New Insights into Mechanisms of Neurodegeneration
    Proteomics and Alcoholism
    Proteomic Studies of Traumatic Brain Injury
    Influence of Huntington's Disease on the Human and Mouse Proteome
    Section V:
    Overview of the Neuroproteome
    Proteomics - Application to the Brain

Product details

  • No. of pages: 352
  • Language: English
  • Copyright: © Academic Press 2004
  • Published: October 13, 2004
  • Imprint: Academic Press
  • eBook ISBN: 9780080522463

About the Serial Volume Editor

Lisa A. Neuhold

Affiliations and Expertise

Program Director, Genetics and Proteomics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, U.S.A.

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