Section I: High-Throughput Technologies Biomarker Discovery Using Molecular Profiling Approaches Proteomic Analysis of Mitochondrial Proteins Section II: Proteomic Applications NMDA Receptors, Neural Pathways and Protein Interaction Databases Dopamine Transporter Networks and Pathways Proteomic Approaches in Drug Discovery and Development Section III: Informatics Proteomic Informatics Proteomics Analysis in Alzheimer's Disease: New Insights into Mechanisms of Neurodegeneration Proteomics and Alcoholism Proteomic Studies of Traumatic Brain Injury Influence of Huntington's Disease on the Human and Mouse Proteome Section V: Overview of the Neuroproteome Proteomics - Application to the Brain
Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer’s disease, alcoholism, trauma/stroke, Huntington's disease, and Parkinson's disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic.
- Describes the latest databases and techniques for analyzing the data generated by proteomics
- Outlines the latest developments in proteomic methods
- Provides numerous color illustrations highlighting the application of proteomics to the identification of novel drug targets and biomarkers
Researchers in academia and industry interested in neuroscience, neurology, molecular biology, and biochemistry, as well as senior undergraduate and graduate students studying these disciplines.
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- © Academic Press 2004
- 13th October 2004
- Academic Press
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Program Director, Genetics and Proteomics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, U.S.A.