
Hsp90 in Cancer: Beyond the Usual Suspects
Description
Key Features
- Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins
- Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology
- Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression
Readership
The information in this volume will be of interest to a broad range of basic and translational scientists, not only in the relatively narrow field of protein folding/biochemistry, but in other areas of cancer biology and clinical oncology.
Table of Contents
- 1. Unusual Suspects in the Twilight Zone between the Hsp90 Interactome and Carcinogenesis
Evangelia Vartholomaiou, Pablo C. Echeverría and Didier Picard
2. Impact of Post-translational Modifications on the Anticancer Activity of Hsp90 Inhibitors
Mark R. Woodford, Diana Dunn, Jonelle B. Miller,Sami Jamal, Len Neckers and Mehdi Mollapour
3. Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects
Gaurav Garg, Anuj Khandelwal and Brian S. J. Blagg
4. HSP90 in Cancer: Transcriptional Roles in the Nucleus
S. K. Calderwood and L. Neckers
5. Hsp90 as a ‘Chaperone’ of the Epigenome: Insights and Opportunities for Cancer Therapy
Jennifer S. Isaacs
6. Emerging Roles of Extracellular Hsp90 in Cancer
Daniel Senh Wong and Daniel G. Jay
7. GRP94/gp96 in Cancer: Biology, Structure, Immunology and Drug Development
Bill X Wu, Feng Hong, Yongliang Zhang, Ephraim Ansa-Addo and Zihai Li
8. HSP90 and Immune Modulation in Cancer
Michael W. Graner
9. Hsp90: A Global Regulator of the Genotype-To-Phenotype Map in Cancers
Daniel Jarosz
Product details
- No. of pages: 288
- Language: English
- Copyright: © Academic Press 2016
- Published: February 22, 2016
- Imprint: Academic Press
- Hardcover ISBN: 9780128022900
- eBook ISBN: 9780128024836
About the Serial Volume Editors
Jennifer Isaacs
Affiliations and Expertise
Luke Whitesell
Luke pursued graduate work in pharmacology at Cambridge University prior to completing medical training at Johns Hopkins University and residency at Boston Children’s Hospital. After fellowship training at the National Cancer Institute he joined the University of Arizona where he was Professor of Pediatric Oncology in the College of Medicine prior to taking his current position at the Whitehead Institute in Cambridge, MA.
Affiliations and Expertise
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