Host Response to Biomaterials

1st Edition

The Impact of Host Response on Biomaterial Selection

Editors: Stephen Badylak
Hardcover ISBN: 9780128001967
eBook ISBN: 9780128005002
Imprint: Academic Press
Published Date: 7th May 2015
Page Count: 460
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Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response.

The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions.

Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine.

Key Features

  • Explains the various categories of biomaterials and their significance for clinical applications
  • Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine
  • Includes regulations regarding combination devices


Biomedical engineers, Biomaterials scientists, Medical device developers, undergraduate and graduate level students in biomedical engineering, bioengineering, and materials science programs

Table of Contents

  • List of Contributors
  • Foreword
  • Preface
  • Acknowledgments
  • Chapter 1. Factors Which Affect the Host Response to Biomaterials

    • Introduction
    • Biomaterial–Host Interaction
    • Host Factors
    • Age
    • Nutritional Status
    • Anatomic Factors
    • Comorbidities
    • Chemotherapy and Radiation Therapy
    • Design Considerations
    • References
  • Chapter 2. Perspectives on the Inflammatory, Healing, and Foreign Body Responses to Biomaterials and Medical Devices

    • Introduction
    • Blood–Material Interactions/Provisional Matrix Formation
    • Acute Inflammation
    • Chronic Inflammation
    • Granulation Tissue
    • Foreign Body Reaction
    • Fibrosis/Fibrous Encapsulation
    • Innate and Adaptive Immune Responses
    • Discussion and Perspectives
    • References
  • Chapter 3. The Biocompatibility of Implant Materials

    • Introduction
    • The Meaning of Biocompatibility
    • Biocompatibility: Historical Thinking
    • Biocompatibility Today
    • Changing the Paradigm of Biocompatibility
    • Relevance to Biocompatibility
    • Conclusions
    • References
  • Chapter 4. Host Response to Naturally Derived Biomaterials

    • Introduction
    • The Use of Decellularized Tissue as a Biomaterial for Surgical Reconstruction and Constructive Remodeling
    • Immune Rejection
    • Decellularization Processes
    • α-Gal Epitope
    • DNA Content and Degree of Decellularization
    • Damage-Associated Molecular Pattern Molecules
    • Chemical Cross-Linking of ECM Scaffolds
    • Response to Individual ECM Components and Degradation Products
    • Degradation of Naturally Derived Biomaterials
    • Effect of Source Animal Age on Natural Biomaterial Host Response
    • The Host Response to ECM Biomaterials
    • <li


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© Academic Press 2015
Academic Press
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About the Editor

Stephen Badylak

Dr. Badylak is Deputy Director of the McGowan Institute for Regenerative Medicine, Director of the Center for Preclinical Testing, and directs a laboratory focused upon the use of biologic scaffolds composed of extracellular matrix (ECM) to facilitate functional tissue regeneration. The focus of Dr. Badylak's work has been the mechanisms by which extracellular matrix signals host tissues to promote and support functional tissue reconstruction.

Affiliations and Expertise

DVM, PhD, MD, Professor of Surgery, University of Pittsburgh, Pittsburgh, PA, USA