Hormones, Regulators and Hippocampus

Hormones, Regulators and Hippocampus

1st Edition - February 16, 2022

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  • Editor: Gerald Litwack
  • Hardcover ISBN: 9780323992213
  • eBook ISBN: 9780323992220

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Description

Hormones, Regulators and Hippocampus, Volume 118 in the Vitamins and Hormones serial highlights new advances in the field, with this new volume presenting interesting chapters, including Thyroid hormone regulation of adult hippocampal neurogenesis – putative molecular and cellular mechanisms, Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus, Oxytocin and vasopressin in the hippocampus, Steroid hormones and hippocampal neurogenesis in the adult mammalian brain, Steroidogenic enzymes in the hippocampus: transcriptional regulation aspects, Ectonucleotidases in the hippocampus: spatial distribution and expression after ovariectomy and estradiol replacement, and much more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Vitamins and Hormones serials
  • Updated release includes the latest information on Hormones, Regulators and Hippocampus

Readership

Undergraduates, graduates, academics, and researchers in the field of vitamins and hormones

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Former Editors
  • Contributors
  • Preface
  • Chapter One: Thyroid hormone regulation of adult hippocampal neurogenesis: Putative molecular and cellular mechanisms
  • Abstract
  • 1: Introduction
  • 2: Thyroid hormone and thyroid hormone receptors (TRs)
  • 3: Adult hippocampal neurogenesis
  • 4: Thyroid hormone signaling and regulation of adult hippocampal neurogenesis
  • 5: Role of TRs in the modulation of adult hippocampal neurogenesis
  • 6: TR target genes and relevance to the effects of thyroid hormone on adult hippocampal neurogenesis
  • 7: Relevance of mitochondrial and lipid metabolism to the effects of thyroid hormone on adult hippocampal neurogenesis
  • 8: Conclusions
  • Acknowledgments
  • References
  • Chapter Two: Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus
  • Abstract
  • 1: Thyroid hormone and glucocorticoid action in the hippocampus
  • 2: Effects of thyroid hormone on the hippocampus
  • 3: Effects of stress and glucocorticoid on the hippocampus
  • 4: Thyroid hormone and glucocorticoid synergy in development
  • 5: Conclusions and recommendations
  • Acknowledgment
  • References
  • Chapter Three: Oxytocin and vasopressin in the hippocampus
  • Abstract
  • 1: Oxytocin and vasopressin
  • 2: Hippocampus
  • 3: Role of oxytocin and vasopressin in neurodevelopment
  • 4: Roles of oxytocin and vasopressin in the adult hippocampus
  • 5: Conclusion
  • References
  • Chapter Four: Steroid hormones and hippocampal neurogenesis in the adult mammalian brain
  • Abstract
  • 1: Adult hippocampal neurogenesis
  • 2: Sex differences in neurogenesis in the hippocampus of adults
  • 3: What is the function of adult neurogenesis in the hippocampus?
  • 4: Stress, glucocorticoids, and neurogenesis across development
  • 5: Neurogenesis and estrogens
  • 6: Hippocampal neurogenesis and androgens
  • 7: Conclusions
  • References
  • Chapter Five: Steroidogenic enzymes in the hippocampus: Transcriptional regulation aspects
  • Abstract
  • 1: Introduction
  • 2: Hippocampus, memory and neurosteroids
  • 3: Hippocampal steroidogenic enzymes and neurosteroid synthesis
  • 4: Physiological and pathological effects on steroidogenic enzyme expression
  • 5: Transcriptional regulation of steroidogenic enzyme expression: insights into DNA methylation.
  • 6: Histone modification and non-coding RNA
  • 7: Conclusions and future perspectives
  • Acknowledgments
  • Declaration of interest
  • Funding
  • References
  • Chapter Six: Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement
  • Abstract
  • 1: Introduction
  • 2: Purinergic signaling system
  • 3: Ectonucleotidases family
  • 4: Spatial distribution of ectonucleotidases in female rat hippocampus and influence of OVX and E2
  • 5: E2 application modulates ectonucleotidases in the hippocampal synapses of male rats
  • 6: Conclusion
  • Acknowledgment
  • References
  • Chapter Seven: Actions of Klotho on hippocampal neuronal cells
  • Abstract
  • 1: Introduction
  • 2: Klotho structure, function, and activity
  • 3: Klotho and hippocampus
  • 4: Conclusion and perspectives
  • Acknowledgments
  • References
  • Chapter Eight: Intracellular and extracelluar cyclic GMP in the brain and the hippocampus
  • Abstract
  • 1: Synthesis, degradation and secretion of cGMP
  • 2: cGMP mediators and functions in health and disease
  • 3: cGMP in the brain and the hippocampus
  • 4: Extracellular cGMP and brain function
  • 5: Conclusions and future directions
  • References
  • Chapter Nine: The role of growth hormone in hippocampal function
  • Abstract
  • 1: Introduction
  • 2: Hippocampus structure and function
  • 3: Growth hormone-receptor system
  • 4: Growth hormone regulation of hippocampal function
  • 5: Growth hormone deficiency (GHD) therapy and the hippocampus
  • 6: Growth hormone therapy and the cognitive improvement in the traumatic injured brain
  • 7: Growth hormone and hypoxia-ischemia hippocampal injury
  • 8: Conclusions
  • Acknowledgments
  • References
  • Chapter Ten: Leptin regulation of synaptic function at hippocampal TA-CA1 and SC-CA1 synapses
  • Abstract
  • 1: Introduction
  • 2: Leptin and leptin receptors
  • 3: LepR signal transduction
  • 4: LepR expression in the CNS
  • 5: Leptin regulation of hippocampal SC-CA1 synapses
  • 6: Leptin induces LTP at adult SC-CA1 synapses
  • 7: Role of NMDA receptor subunits
  • 8: Excitatory TA-CA1 synapses
  • 9: Synaptic plasticity at TA-CA1 synapses
  • 10: Activity-dependent LTD at TA-CA1 synapses
  • 11: Leptin has the ability to induce LTD at adult TA-CA1 synapses
  • 12: Leptin induces rapid structural changes
  • 13: Functional implications of the synaptic actions of leptin
  • 14: Age-related changes in leptin function
  • 15: Conclusions
  • References
  • Chapter Eleven: Ghrelin mediated hippocampal neurogenesis
  • Abstract
  • 1: Ghrelin
  • 2: Ghrelin's molecular and cellular mechanisms of action
  • 3: The Hippocampus
  • 4: Conclusions and future directions
  • Acknowledgment
  • References
  • Chapter Twelve: Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus
  • Abstract
  • 1: GOAT is necessary for ghrelin physiology
  • 2: Cellular localization of GOAT in the hippocampus
  • 3: Binding profile of acyl ghrelin in the hippocampal subfields
  • 4: Acylation of ghrelin occurs in the hippocampus
  • 5: Role of GOAT in the hippocampal function
  • 6: Conclusions and future directions
  • Acknowledgments
  • References
  • Chapter Thirteen: Hippocampal orexin receptors: Localization and function
  • Abstract
  • 1: Overview
  • 2: Origin of the orexinergic system
  • 3: Distribution of the orexinergic system
  • 4: Orexin in the hippocampus
  • 5: Orexin receptor expression in the hippocampus
  • 6: Hippocampal OX1R functional significance
  • 7: Orexin receptor 2 functional significance
  • 8: Concluding remarks and future directions
  • Acknowledgments
  • References
  • Further reading
  • Chapter Fourteen: A role for insulin-like growth factor-1 in hippocampal plasticity following traumatic brain injury
  • Abstract
  • 1: Introduction
  • 2: Modulation of hippocampal synaptic structure and function by TBI and IGF-1
  • 3: Potential for IGF-1 to facilitate neurogenesis in the traumatically injured brain
  • 4: Future directions
  • Acknowledgments
  • References
  • Chapter Fifteen: Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus
  • Abstract
  • 1: Peripheral GLP-1
  • 2: GLP-1 in the brain
  • 3: The GLP-1 receptor
  • 4: GLP-1 analogs effects on memory and learning
  • 5: GLP-1 analogs effects on food intake and food-motivated behavior
  • 6: Anti-inflammatory properties of GLP-1 analogs in the hippocampus
  • 7: GLP-1 analogs and neurodegenerative disorders: Focusing Alzheimer's disease
  • 8: Conclusions and future directions
  • Acknowledgments
  • References
  • Chapter Sixteen: Highlights regarding prolactin in the dentate gyrus and hippocampus
  • Abstract
  • 1: Introduction
  • 2: The prolactin receptor in the central nervous system
  • 3: The origin of prolactin in the central nervous system
  • 4: The effects of prolactin on the hippocampus
  • References

Product details

  • No. of pages: 524
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: February 16, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323992213
  • eBook ISBN: 9780323992220

About the Editor

Gerald Litwack

Gerald Litwack
Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

Affiliations and Expertise

Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine, USA; Toluca Lake, North Hollywood, California, USA

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