Hormones, Regulators and Hippocampus

1st Edition, Volume 118 - February 16, 2022
Editor: Gerald Litwack
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 2 2 1 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 2 2 2 - 0

Hormones, Regulators and Hippocampus, Volume 118 in the Vitamins and Hormones serial highlights new advances in the field, with this new volume presenting interesting chapters, inc… Read more

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Hormones, Regulators and Hippocampus, Volume 118 in the Vitamins and Hormones serial highlights new advances in the field, with this new volume presenting interesting chapters, including Thyroid hormone regulation of adult hippocampal neurogenesis – putative molecular and cellular mechanisms, Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus, Oxytocin and vasopressin in the hippocampus, Steroid hormones and hippocampal neurogenesis in the adult mammalian brain, Steroidogenic enzymes in the hippocampus: transcriptional regulation aspects, Ectonucleotidases in the hippocampus: spatial distribution and expression after ovariectomy and estradiol replacement, and much more.

Cover image
Title page
Table of Contents
Copyright
Former Editors
Contributors
Preface
Chapter One: Thyroid hormone regulation of adult hippocampal neurogenesis: Putative molecular and cellular mechanisms
Abstract
1: Introduction
2: Thyroid hormone and thyroid hormone receptors (TRs)
3: Adult hippocampal neurogenesis
4: Thyroid hormone signaling and regulation of adult hippocampal neurogenesis
5: Role of TRs in the modulation of adult hippocampal neurogenesis
6: TR target genes and relevance to the effects of thyroid hormone on adult hippocampal neurogenesis
7: Relevance of mitochondrial and lipid metabolism to the effects of thyroid hormone on adult hippocampal neurogenesis
8: Conclusions
Acknowledgments
References
Chapter Two: Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus
Abstract
1: Thyroid hormone and glucocorticoid action in the hippocampus
2: Effects of thyroid hormone on the hippocampus
3: Effects of stress and glucocorticoid on the hippocampus
4: Thyroid hormone and glucocorticoid synergy in development
5: Conclusions and recommendations
Acknowledgment
References
Chapter Three: Oxytocin and vasopressin in the hippocampus
Abstract
1: Oxytocin and vasopressin
2: Hippocampus
3: Role of oxytocin and vasopressin in neurodevelopment
4: Roles of oxytocin and vasopressin in the adult hippocampus
5: Conclusion
References
Chapter Four: Steroid hormones and hippocampal neurogenesis in the adult mammalian brain
Abstract
1: Adult hippocampal neurogenesis
2: Sex differences in neurogenesis in the hippocampus of adults
3: What is the function of adult neurogenesis in the hippocampus?
4: Stress, glucocorticoids, and neurogenesis across development
5: Neurogenesis and estrogens
6: Hippocampal neurogenesis and androgens
7: Conclusions
References
Chapter Five: Steroidogenic enzymes in the hippocampus: Transcriptional regulation aspects
Abstract
1: Introduction
2: Hippocampus, memory and neurosteroids
3: Hippocampal steroidogenic enzymes and neurosteroid synthesis
4: Physiological and pathological effects on steroidogenic enzyme expression
5: Transcriptional regulation of steroidogenic enzyme expression: insights into DNA methylation.
6: Histone modification and non-coding RNA
7: Conclusions and future perspectives
Acknowledgments
Declaration of interest
Funding
References
Chapter Six: Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement
Abstract
1: Introduction
2: Purinergic signaling system
3: Ectonucleotidases family
4: Spatial distribution of ectonucleotidases in female rat hippocampus and influence of OVX and E2
5: E2 application modulates ectonucleotidases in the hippocampal synapses of male rats
6: Conclusion
Acknowledgment
References
Chapter Seven: Actions of Klotho on hippocampal neuronal cells
Abstract
1: Introduction
2: Klotho structure, function, and activity
3: Klotho and hippocampus
4: Conclusion and perspectives
Acknowledgments
References
Chapter Eight: Intracellular and extracelluar cyclic GMP in the brain and the hippocampus
Abstract
1: Synthesis, degradation and secretion of cGMP
2: cGMP mediators and functions in health and disease
3: cGMP in the brain and the hippocampus
4: Extracellular cGMP and brain function
5: Conclusions and future directions
References
Chapter Nine: The role of growth hormone in hippocampal function
Abstract
1: Introduction
2: Hippocampus structure and function
3: Growth hormone-receptor system
4: Growth hormone regulation of hippocampal function
5: Growth hormone deficiency (GHD) therapy and the hippocampus
6: Growth hormone therapy and the cognitive improvement in the traumatic injured brain
7: Growth hormone and hypoxia-ischemia hippocampal injury
8: Conclusions
Acknowledgments
References
Chapter Ten: Leptin regulation of synaptic function at hippocampal TA-CA1 and SC-CA1 synapses
Abstract
1: Introduction
2: Leptin and leptin receptors
3: LepR signal transduction
4: LepR expression in the CNS
5: Leptin regulation of hippocampal SC-CA1 synapses
6: Leptin induces LTP at adult SC-CA1 synapses
7: Role of NMDA receptor subunits
8: Excitatory TA-CA1 synapses
9: Synaptic plasticity at TA-CA1 synapses
10: Activity-dependent LTD at TA-CA1 synapses
11: Leptin has the ability to induce LTD at adult TA-CA1 synapses
12: Leptin induces rapid structural changes
13: Functional implications of the synaptic actions of leptin
14: Age-related changes in leptin function
15: Conclusions
References
Chapter Eleven: Ghrelin mediated hippocampal neurogenesis
Abstract
1: Ghrelin
2: Ghrelin's molecular and cellular mechanisms of action
3: The Hippocampus
4: Conclusions and future directions
Acknowledgment
References
Chapter Twelve: Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus
Abstract
1: GOAT is necessary for ghrelin physiology
2: Cellular localization of GOAT in the hippocampus
3: Binding profile of acyl ghrelin in the hippocampal subfields
4: Acylation of ghrelin occurs in the hippocampus
5: Role of GOAT in the hippocampal function
6: Conclusions and future directions
Acknowledgments
References
Chapter Thirteen: Hippocampal orexin receptors: Localization and function
Abstract
1: Overview
2: Origin of the orexinergic system
3: Distribution of the orexinergic system
4: Orexin in the hippocampus
5: Orexin receptor expression in the hippocampus
6: Hippocampal OX1R functional significance
7: Orexin receptor 2 functional significance
8: Concluding remarks and future directions
Acknowledgments
References
Further reading
Chapter Fourteen: A role for insulin-like growth factor-1 in hippocampal plasticity following traumatic brain injury
Abstract
1: Introduction
2: Modulation of hippocampal synaptic structure and function by TBI and IGF-1
3: Potential for IGF-1 to facilitate neurogenesis in the traumatically injured brain
4: Future directions
Acknowledgments
References
Chapter Fifteen: Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus
Abstract
1: Peripheral GLP-1
2: GLP-1 in the brain
3: The GLP-1 receptor
4: GLP-1 analogs effects on memory and learning
5: GLP-1 analogs effects on food intake and food-motivated behavior
6: Anti-inflammatory properties of GLP-1 analogs in the hippocampus
7: GLP-1 analogs and neurodegenerative disorders: Focusing Alzheimer's disease
8: Conclusions and future directions
Acknowledgments
References
Chapter Sixteen: Highlights regarding prolactin in the dentate gyrus and hippocampus
Abstract
1: Introduction
2: The prolactin receptor in the central nervous system
3: The origin of prolactin in the central nervous system
4: The effects of prolactin on the hippocampus
References

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Gerald Litwack