Hormones, Brain and Behavior

Hormones, Brain and Behavior

3rd Edition - November 9, 2016

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  • Editors-in-Chief: Donald W Pfaff, Marian Joels
  • eBook ISBN: 9780128036082
  • Hardcover ISBN: 9780128035924

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Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields.

Key Features

  • Comprehensive and updated coverage of a rapidly growing field of research
  • Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics
  • Covers an unusual breadth of topics and subject fields, ranging from molecules to ecophysiology, and from basic science to clinical research
  • Ideal resource for interdisciplinary learning and understanding in the fields of hormones and behavior


Researchers, students, fellows, and academic clinicians primarily in biology, psychology, psychiatry, neurology, and endocrinology. This work will also appeal to agricultural students and professionals, fisheries personnel, physiologists, biochemists, anatomists, and geneticists

Table of Contents

  • Male sexual behavior
    Female sexual behavior
    Parental behavior
    Social affiliation and pair-bonding
    Hormones and aggressive behavior
    Food intake and its hormonal control
    Body fluid homeostasis
    Stress, opoid peptides, and receptors
    Social stress: effects on hormones, brain and behavior
    Communication by chemical signals
    Hormonal and pheromonal effects on the limbic system: implications for reproductive behavior
    Circadian regulation of endocrine function
    Mammalian seasonal rhythms: behavior and neuroendocrine substrates
    Steroids and learning
    Hormonal effects on memory
    Hormones and prefrontal cortex-related behavior
    Animal welfare in the laboratory and on the farm: behavioral and neuroendocrine indicators
    Reproductive Plasticity in Fish: Evolutionary Lability in the Patterning of Neuroendocrine and Behavioral Traits Underlying Divergent Sexual Phenotypes
    Weakly Electric Fish: Behavior, Neurobiology, and Neuroendocrinology
    Hormonal and Pheromonal control of Behavior in Fish
    Social Regulation of Reproduction: What Changes and Why?
    Sex changing fishes
    Hormones and the Regulation of Vocal Patterns in Amphibians: Xenopus laevis Vocalizations as a Model System
    Endocrinology of Complex Life Cycles: Amphibians
    Sensorimotor Processing Model: Neuroendocrine Control of Reproductive Behaviors in an Amphibian
    Neuroendocrine controls of social behavior in frogs
    Hormones, Brain, and Behavior in Reptiles
    Ecophysiological Studies of Hormone–Behavior Relations in Birds
    Neuroendocrine Regulation of Reproductive Behavior in Birds
    Neural and Hormonal Control of Birdsong
    The function of behavior as assessed by phenotypic engineering with testosterone
    Behavioral effects of rapid changes in steroids in the avian brain
    Nervous System Actions of Insect Developmental Hormones in Adult Insects
    Biogenic Amines as Circulating Hormones in Insects
    Regulation of Honeybee Worker (Apis mellifera) Life Histories by Vitellogenin
    Endocrine Influences on the Organization of Insect Societies (incl. circadian rhythms?)
    Stressed-Out Insects: Hormonal Actions and Behavioral Modifications
    Hormones and behavioral caste in bumble bees
    Rapid membrane effects of estrogens  in the central nervous system
    Estrogen regulation of neurotransmitters and growth factor signaling  
    Genetic mechanisms in neural and hormonal controls over female reproductive behaviors 
    Model systems for the study of androgen-regulated gene expression in the central nervous system
    Molecular Aspects of thyroid hormone-regulated behavior
    Corticosteroid actions on electrical activity in the brain
    Genomic and (epi)genetic aspects of corticosteroid action in brain 
    Mechanisms of aldosterone  action in brain and behavior
    Mechanism of progesterone receptor action in the brain
    Progesterone: synthesis, metabolism, mechanism of action, and effects in the nervous system
    Novel effects of neuroactive steroids in the central nervous system
    Vasopressin receptors
    Cell biology of oxytocin and vasopressin cells
    Electrophysiology and Molecular properties of the oxytocin and vasopressin secreting systems in mammals
    Gonadotropin releasing hormone
    Neurophysiology of GnRH
    Corticotropin releasing factor: putative neurotransmitter actions of a neurohormone
    The brain renin-angiotensin system
    Melanocortin receptors
    The Gonadal Axis: A life perspective
    The Gonadal Axis: Genetic defects - Male
    The Gonadal Axis: Genetic defects - Female
    The Gonadal Axis: Kallmans
    Hypothalamic-Pituitary-Adrenal Axis: CAH
    The Gonadal Axis: Sexual Orientation
    The Gonadal Axis: Transsexualism
    Hypothalamic-Thyroid Axis: Genetic defects and  Iodine deficiency
    Hypothalamic-Pituitary-Adrenal Axis                              
    The Gonadal Axis: Premenstrual Syndrome
    The Gonadal Axis: Assisted Reproduction
    Thyroid hormone replacement                                           
    Glucocorticoid replacement
    The HPA Axis: Depression, Stress and Anxiety               
    The HPA Axis: PTSD
    GH excess and deficiency                                                          
    Pituitary and Hypothalamic tumors                         
    Anorexia and Bulimia
    Obesity and appetite
    Alcohol abuse
    Drug abuse
    Specificity Conferring Mechanism of Glucocorticoid and Mineralocorticoid Action in the Brain
    Growth Hormone IGF-1 and Aging
    Sexual differentiation of the brain- mode, mechanisms, and meaning
    Genetic contribution to sex differences in brain and behavior
    Epigenetic contribution to sex differences in brain and behavior
    Environmental Endocrine Disruption of Brain and Behavior
    Sexual differentiation of neurotransmitters and neuromodulators
    Sexual Differentiation of Mammalian Olfactory Communication
    Early-life stress impact on neurodevelopmental and neuropsychiatric disorders (this would include an epigenetic component)
    Early-Life Experiences: Enduring Behavioral, Neurological, and Endocrinological Consequences
    Thyroid Hormones and Brain Development
    Sexual Differentiation of Brain and Behavior in Birds
    Sexual Differentiation of Behavior in Nonhuman Primates
    Gonadal Hormones and Sexual Differentiation of Human Brain and Behavior
    Sexual identity and sexual orientation
    Influence of gonadal steroid hormones on nervous system structure and function during adolescence
    Neuroendocrine Regulation of Puberty
    Regulation of Human Puberty
    Hormone regulation of neurogenesis across the lifespan
    Effects of Sex Steroids on Damaged Neural Systems
    Effects of stress throughout the lifespan on the brain and behavior
    Reproductive aging of neuroendocrine systems
    Sex Differences in Central Autoimmune Diseases

Product details

  • No. of pages: 2474
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: November 9, 2016
  • Imprint: Academic Press
  • eBook ISBN: 9780128036082
  • Hardcover ISBN: 9780128035924

About the Editors in Chief

Donald W Pfaff

Donald W. Pfaff heads the Laboratory of Neurobiology and Behavior at The Rockefeller University. He received his scientific training at Harvard College and MIT. He is a Member of the U.S. National Academy of Sciences and a Fellow of the American Academy of Arts and Sciences. Pfaff's laboratory focuses on steroid hormones and brain function, genes influencing neuronal functions, and generalized CNS arousal. He is the author or coauthor of over 10 books and more than 900 research publications.

Affiliations and Expertise

Laboratory of Neurobiology and Behavior, Rockefeller University, NY, USA

Marian Joels

Marian Joëls obtained her PhD degree in Utrecht (1984) with David de Wied. She carried out postdoctoral research at the University of Texas Medical Branch in Galveston and at the Scripps Research Institute in La Jolla California. Between 1991 and 2009 she was appointed at the University of Amsterdam, first as associate professor and subsequently as full professor in neurobiology. Since 2009 she is (full) professor of neuroscience in Utrecht. Currently she is scientific director of the Brain Center Rudolf Magnus. Her research focuses on the effects of stress in the brain. With patch clamp technology, she studies how corticosteroid hormones change cellular function of limbic neurons. This is linked to the underlying molecular mechanism and the consequences at the circuit level. As a final step, the effects of stress on functional connectivity and behavioral outcome are studied, both in rodents and humans. In her work, she pays particular attention to the influence of stress during early life and the result of prolonged periods of stress in adulthood. The relevance of such critical periods of stress -in interaction with a vulnerable genetic background- for the development of brain disorders are investigated in various patient cohorts. Her work was published in >275 publications and to date has been cited >15,000 times. Marian Joëls was elected as a member of the Royal Netherlands Academy of Arts and Sciences in 2002. She served as President of the Federation of European Neuroscience Societies between 2012 and 2014.

Affiliations and Expertise

Scientific Director Brain Center Rudolf Magnus, Division Neurosciences, Dept. Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

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