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Hormones, Brain and Behavior - 3rd Edition - ISBN: 9780128035924, 9780128036082

Hormones, Brain and Behavior

3rd Edition

Editors in Chief: Donald W Pfaff Marian Joels
eBook ISBN: 9780128036082
Hardcover ISBN: 9780128035924
Imprint: Academic Press
Published Date: 9th November 2016
Page Count: 2474
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Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology.

This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations.

This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields.

Key Features

  • Comprehensive and updated coverage of a rapidly growing field of research
  • Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics
  • Covers an unusual breadth of topics and subject fields, ranging from molecules to ecophysiology, and from basic science to clinical research
  • Ideal resource for interdisciplinary learning and understanding in the fields of hormones and behavior


Researchers, students, fellows, and academic clinicians primarily in biology, psychology, psychiatry, neurology, and endocrinology. This work will also appeal to agricultural students and professionals, fisheries personnel, physiologists, biochemists, anatomists, and geneticists

Table of Contents

Male sexual behavior
Female sexual behavior
Parental behavior
Social affiliation and pair-bonding
Hormones and aggressive behavior
Food intake and its hormonal control
Body fluid homeostasis
Stress, opoid peptides, and receptors
Social stress: effects on hormones, brain and behavior
Communication by chemical signals
Hormonal and pheromonal effects on the limbic system: implications for reproductive behavior
Circadian regulation of endocrine function
Mammalian seasonal rhythms: behavior and neuroendocrine substrates
Steroids and learning
Hormonal effects on memory
Hormones and prefrontal cortex-related behavior
Animal welfare in the laboratory and on the farm: behavioral and neuroendocrine indicators
Reproductive Plasticity in Fish: Evolutionary Lability in the Patterning of Neuroendocrine and Behavioral Traits Underlying Divergent Sexual Phenotypes
Weakly Electric Fish: Behavior, Neurobiology, and Neuroendocrinology
Hormonal and Pheromonal control of Behavior in Fish
Social Regulation of Reproduction: What Changes and Why?
Sex changing fishes
Hormones and the Regulation of Vocal Patterns in Amphibians: Xenopus laevis Vocalizations as a Model System
Endocrinology of Complex Life Cycles: Amphibians
Sensorimotor Processing Model: Neuroendocrine Control of Reproductive Behaviors in an Amphibian
Neuroendocrine controls of social behavior in frogs
Hormones, Brain, and Behavior in Reptiles
Ecophysiological Studies of Hormone–Behavior Relations in Birds
Neuroendocrine Regulation of Reproductive Behavior in Birds
Neural and Hormonal Control of Birdsong
The function of behavior as assessed by phenotypic engineering with testosterone
Behavioral effects of rapid changes in steroids in the avian brain
Nervous System Actions of Insect Developmental Hormones in Adult Insects
Biogenic Amines as Circulating Hormones in Insects
Regulation of Honeybee Worker (Apis mellifera) Life Histories by Vitellogenin
Endocrine Influences on the Organization of Insect Societies (incl. circadian rhythms?)
Stressed-Out Insects: Hormonal Actions and Behavioral Modifications
Hormones and behavioral caste in bumble bees
Rapid membrane effects of estrogens in the central nervous system
Estrogen regulation of neurotransmitters and growth factor signaling
Genetic mechanisms in neural and hormonal controls over female reproductive behaviors
Model systems for the study of androgen-regulated gene expression in the central nervous system
Molecular Aspects of thyroid hormone-regulated behavior
Corticosteroid actions on electrical activity in the brain
Genomic and (epi)genetic aspects of corticosteroid action in brain
Mechanisms of aldosterone action in brain and behavior
Mechanism of progesterone receptor action in the brain
Progesterone: synthesis, metabolism, mechanism of action, and effects in the nervous system
Novel effects of neuroactive steroids in the central nervous system
Vasopressin receptors
Cell biology of oxytocin and vasopressin cells
Electrophysiology and Molecular properties of the oxytocin and vasopressin secreting systems in mammals
Gonadotropin releasing hormone
Neurophysiology of GnRH
Corticotropin releasing factor: putative neurotransmitter actions of a neurohormone
The brain renin-angiotensin system
Melanocortin receptors
The Gonadal Axis: A life perspective
The Gonadal Axis: Genetic defects - Male
The Gonadal Axis: Genetic defects - Female
The Gonadal Axis: Kallmans
Hypothalamic-Pituitary-Adrenal Axis: CAH
The Gonadal Axis: Sexual Orientation
The Gonadal Axis: Transsexualism
Hypothalamic-Thyroid Axis: Genetic defects and Iodine deficiency
Hypothalamic-Pituitary-Adrenal Axis
The Gonadal Axis: Premenstrual Syndrome
The Gonadal Axis: Assisted Reproduction
Thyroid hormone replacement
Glucocorticoid replacement
The HPA Axis: Depression, Stress and Anxiety
The HPA Axis: PTSD
GH excess and deficiency
Pituitary and Hypothalamic tumors
Anorexia and Bulimia
Obesity and appetite
Alcohol abuse
Drug abuse
Specificity Conferring Mechanism of Glucocorticoid and Mineralocorticoid Action in the Brain
Growth Hormone IGF-1 and Aging
Sexual differentiation of the brain- mode, mechanisms, and meaning
Genetic contribution to sex differences in brain and behavior
Epigenetic contribution to sex differences in brain and behavior
Environmental Endocrine Disruption of Brain and Behavior
Sexual differentiation of neurotransmitters and neuromodulators
Sexual Differentiation of Mammalian Olfactory Communication
Early-life stress impact on neurodevelopmental and neuropsychiatric disorders (this would include an epigenetic component)
Early-Life Experiences: Enduring Behavioral, Neurological, and Endocrinological Consequences
Thyroid Hormones and Brain Development
Sexual Differentiation of Brain and Behavior in Birds
Sexual Differentiation of Behavior in Nonhuman Primates
Gonadal Hormones and Sexual Differentiation of Human Brain and Behavior
Sexual identity and sexual orientation
Influence of gonadal steroid hormones on nervous system structure and function during adolescence
Neuroendocrine Regulation of Puberty
Regulation of Human Puberty
Hormone regulation of neurogenesis across the lifespan
Effects of Sex Steroids on Damaged Neural Systems
Effects of stress throughout the lifespan on the brain and behavior
Reproductive aging of neuroendocrine systems
Sex Differences in Central Autoimmune Diseases


No. of pages:
© Academic Press 2016
9th November 2016
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editors in Chief

Donald W Pfaff

Donald W. Pfaff heads the Laboratory of Neurobiology and Behavior at The Rockefeller University. He received his scientific training at Harvard College and MIT. He is a Member of the U.S. National Academy of Sciences and a Fellow of the American Academy of Arts and Sciences. Pfaff's laboratory focuses on steroid hormones and brain function, genes influencing neuronal functions, and generalized CNS arousal. He is the author or coauthor of over 10 books and more than 900 research publications.

Affiliations and Expertise

Laboratory of Neurobiology and Behavior, Rockefeller University, NY, USA

Marian Joels

Marian Joëls obtained her PhD degree in Utrecht (1984) with David de Wied. She carried out postdoctoral research at the University of Texas Medical Branch in Galveston and at the Scripps Research Institute in La Jolla California. Between 1991 and 2009 she was appointed at the University of Amsterdam, first as associate professor and subsequently as full professor in neurobiology. Since 2009 she is (full) professor of neuroscience in Utrecht. Currently she is scientific director of the Brain Center Rudolf Magnus. Her research focuses on the effects of stress in the brain. With patch clamp technology, she studies how corticosteroid hormones change cellular function of limbic neurons. This is linked to the underlying molecular mechanism and the consequences at the circuit level. As a final step, the effects of stress on functional connectivity and behavioral outcome are studied, both in rodents and humans. In her work, she pays particular attention to the influence of stress during early life and the result of prolonged periods of stress in adulthood. The relevance of such critical periods of stress -in interaction with a vulnerable genetic background- for the development of brain disorders are investigated in various patient cohorts. Her work was published in >275 publications and to date has been cited >15,000 times. Marian Joëls was elected as a member of the Royal Netherlands Academy of Arts and Sciences in 2002. She served as President of the Federation of European Neuroscience Societies between 2012 and 2014.

Affiliations and Expertise

Scientific Director Brain Center Rudolf Magnus, Division Neurosciences, Dept. Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands


"Researchers specializing in the mechanisms of neuroendocrinological systems will find this to be an invaluable reference...The introductory background information and figures also make this a great reference for students in research or clinical endocrinology. Overall, This is a comprehensive, up-to-date reference on the current state of knowledge in the field. Score: 95 - 4 Stars!" --Doody's

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