Hormones and Human Breast Cancer

Hormones and Human Breast Cancer

An Account of 15 Years Study

1st Edition - January 1, 1970

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  • Author: John Hayward
  • eBook ISBN: 9781483194172

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Recent Results in Cancer Research: Hormones and Human Breast Cancer provides information pertinent to the fundamental aspects of breast cancer and hormones. This book discusses the endocrine factors involved in breast cancer. Organized into two parts encompassing 11 chapters, this book begins with an overview of the process of castration as an effective therapeutic measure in many pre-menopausal patients with advanced breast cancer. This text then discusses the response rate following ablation wherein only 60 percent of patients subjected to hormone therapy as a first treatment for recurrence will survive to ablation. Other chapters consider the microscopical features of a tumor. This book discusses as well the prescription of corticosteroids as treatment, which originates from the mechanism of response that followed adrenalectomy or hypophysectomy. The final chapter deals with the use of radio-immunoassay methods in treating breast cancer. This book is a valuable resource for biochemists, scientists, and physicians.

Table of Contents

  • Chapter 1 Historical Developments

    Animal Studies

    Human Studies


    Part I — Hormones in Treatment and Prophylaxis

    Chapter 2 The Ovaries

    1. Castration in the Advanced Disease

    Castration as a Prophylactic Measure

    The Comparative Values of Therapeutic and Prophylactic Castration

    Surgical Castration Compared with Irradiation Castration

    The Physiological Significance of Castration

    Summary and Conclusions


    Chapter 3 The Adrenals and the Pituitary

    1. The Remission Rates from Adrenalectomy and Hypophysectomy

    2. The Timing of Adrenalectomy and Hypophysectomy

    3. The Comparative Results of Hormone Therapy and Ablation

    4. Techniques

    5. Endocrine Changes after Ablation

    Summary and Conclusions


    Chapter 4 Tests of Prediction

    1. Clinical Methods

    2. Hormone Assays

    Summary and Conclusions


    Chapter 5 Androgens and Oestrogens

    1. Response

    2. Factors Associated with Hormone Action

    3. Choice of Compound and Dosage

    4. Comparison of Androgens and Oestrogens

    5. The Place of Androgens in Prophylaxis

    6. Mode of Action

    7. Hypercalcaemia

    Summary and Conclusions


    Chapter 6 Corticosteroids and Progestogens

    1. Corticosteroids

    2. Progestogens

    Summary and Conclusions


    Part II — The Hormonal Environment and Hormone Assays

    Chapter 7 Antecedent and Racial Factors

    1. Heredity

    2. Marriage

    3. Pregnancy and Parity

    4. Lactation

    5. Menstrual History and the Menopause

    6. Bilateral Disease

    7. Gynaecological Disease

    8. Racial Factors

    Summary and Conclusions


    Chapter 8 Oestrogens

    Exogenous Oestrogens

    Endogenous Oestrogens

    Summary and Conclusions


    Chapter 9 Androgens and Corticosteroids

    The Guernsey Trial

    Plasma Studies

    Summary and Conclusions


    Chapter 10 Pituitary and Thyroid Hormones

    1. Gonadotrophins

    2. Growth Hormone and Prolactin


    1. Thyroid Disease and the Incidence of Breast Cancer

    2. Thyroid Factors in the Established Disease

    3. Thyroid as Treatment

    4. Thyroid Effects on Endocrine Metabolism

    Summary and Conclusions


    Chapter 11 The Present and the Future

Product details

  • No. of pages: 168
  • Language: English
  • Copyright: © Butterworth-Heinemann 1970
  • Published: January 1, 1970
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483194172

About the Author

John Hayward

About the Editors

V. G. Allfrey

M. Allgöwer

K. H. Bauer

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