
Hormones and Human Breast Cancer
An Account of 15 Years Study
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Recent Results in Cancer Research: Hormones and Human Breast Cancer provides information pertinent to the fundamental aspects of breast cancer and hormones. This book discusses the endocrine factors involved in breast cancer. Organized into two parts encompassing 11 chapters, this book begins with an overview of the process of castration as an effective therapeutic measure in many pre-menopausal patients with advanced breast cancer. This text then discusses the response rate following ablation wherein only 60 percent of patients subjected to hormone therapy as a first treatment for recurrence will survive to ablation. Other chapters consider the microscopical features of a tumor. This book discusses as well the prescription of corticosteroids as treatment, which originates from the mechanism of response that followed adrenalectomy or hypophysectomy. The final chapter deals with the use of radio-immunoassay methods in treating breast cancer. This book is a valuable resource for biochemists, scientists, and physicians.
Table of Contents
Chapter 1 Historical Developments
Animal Studies
Human Studies
References
Part I — Hormones in Treatment and Prophylaxis
Chapter 2 The Ovaries
1. Castration in the Advanced Disease
Castration as a Prophylactic Measure
The Comparative Values of Therapeutic and Prophylactic Castration
Surgical Castration Compared with Irradiation Castration
The Physiological Significance of Castration
Summary and Conclusions
References
Chapter 3 The Adrenals and the Pituitary
1. The Remission Rates from Adrenalectomy and Hypophysectomy
2. The Timing of Adrenalectomy and Hypophysectomy
3. The Comparative Results of Hormone Therapy and Ablation
4. Techniques
5. Endocrine Changes after Ablation
Summary and Conclusions
References
Chapter 4 Tests of Prediction
1. Clinical Methods
2. Hormone Assays
Summary and Conclusions
References
Chapter 5 Androgens and Oestrogens
1. Response
2. Factors Associated with Hormone Action
3. Choice of Compound and Dosage
4. Comparison of Androgens and Oestrogens
5. The Place of Androgens in Prophylaxis
6. Mode of Action
7. Hypercalcaemia
Summary and Conclusions
References
Chapter 6 Corticosteroids and Progestogens
1. Corticosteroids
2. Progestogens
Summary and Conclusions
References
Part II — The Hormonal Environment and Hormone Assays
Chapter 7 Antecedent and Racial Factors
1. Heredity
2. Marriage
3. Pregnancy and Parity
4. Lactation
5. Menstrual History and the Menopause
6. Bilateral Disease
7. Gynaecological Disease
8. Racial Factors
Summary and Conclusions
References
Chapter 8 Oestrogens
Exogenous Oestrogens
Endogenous Oestrogens
Summary and Conclusions
References
Chapter 9 Androgens and Corticosteroids
The Guernsey Trial
Plasma Studies
Summary and Conclusions
References
Chapter 10 Pituitary and Thyroid Hormones
1. Gonadotrophins
2. Growth Hormone and Prolactin
Thyroid
1. Thyroid Disease and the Incidence of Breast Cancer
2. Thyroid Factors in the Established Disease
3. Thyroid as Treatment
4. Thyroid Effects on Endocrine Metabolism
Summary and Conclusions
References
Chapter 11 The Present and the Future
Product details
- No. of pages: 168
- Language: English
- Copyright: © Butterworth-Heinemann 1970
- Published: January 1, 1970
- Imprint: Butterworth-Heinemann
- eBook ISBN: 9781483194172
About the Author
John Hayward
About the Editors
V. G. Allfrey
M. Allgöwer
K. H. Bauer
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