Hormones and Embryonic Development

Hormones and Embryonic Development

Advances in the Biosciences

1st Edition - January 17, 1975

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  • Editor: G. Raspé
  • eBook ISBN: 9781483151717

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Description

Advances in the Biosciences 13: Hormones and Embryonic Development investigates various aspects of hormones and embryonic development, including their physiological and pharmacological effects. More specifically, this volume considers which maternal hormones are essential for normal mammalian embryonic development, as well as the time course of the occurrence of endocrine systems during mammalian fetal development. In addition, it examines the role of maternal or fetal hormones in the induction and differentiation processes during embryonic or fetal development. Comprised of 13 chapters, this book begins with an analysis of the metabolic effects of insulin and glucagon in fetal and newborn rats, as well as their physiologic significance during the perinatal period in rat and other species. The next chapter deals with sexual differentiation in the rat fetus; how hormones regulate sexual development and disrupt sexual differentiation; the role of progesterone and estrone in pregnant rats fed a protein-free diet; and effects of brain implants of testosterone propionate in newborn hamsters on sexual differentiation. The link between diethylstilbestrol ingestion during pregnancy and development of clear-cell adenocarcinoma in the vagina and cervix of the female offspring is also examined. This monograph will be of interest to biologists, bioscientists, physiologists, and pharmacologists.

Table of Contents

  • Chapter 1: Introduction

    Publisher Summary

    Chapter 2: Glucagon and Perinatal Metabolism in the Rat

    Abstract:

    Problem

    Material and Methods

    Results and Discussion

    Chapter 3: Sexual Programing of the Rat Fetus and Neonate Studied by Selective Biochemical Testosterone-Depriving Agents

    Publisher Summary

    Introduction

    Hypothalamic Sex

    Anatomic Sex

    Sexual Programing of Human Anatomic Sex

    Testicular Feminization

    Biochemical Sex

    Development of Testosterone Biosynthesis

    Testosterone Deficiency in Congenital Adrenal Hyperplasia

    Inhibition of the Oxidoreductase

    Animal Models

    Critical Periods

    Prevention of Genital Defects

    Mammary Gland Differentiation

    Antibodies to Testosterone

    Antibodies to LH:FSH

    Progestins and Hypospadias

    Congenital Adrenal Hyperplasia Produced by Estradiol-17β

    Further Evidence for Explanation of Paradoxic Effects

    Specificity and Persistence of Analog Uptake and Action

    Pubertal Expression of Programing Defects in the Fetus

    Female Hypothalamic Centers Controlling Puberty

    Saccharin Preference

    Target Organ, Steroid-Metabolizing Enzyme Levels

    Castration-Induced Elevation of Adrenal 5α-Reductase

    Review

    Acknowledgements:

    Chapter 4: Hormonal Control of Sexual Development

    Publisher Summary

    Introduction

    History of Experimental Research on Sex Differentiation

    The Sex-Dependent Differentiation of the Mammary Gland

    Conclusion

    Acknowledgements:

    Chapter 5: Hormone-Induced Disturbances in Sexual Differentiation

    Abstract:

    Introduction

    Basic Remarks on Sex Differentiation

    Progestogens

    Effects of “pure”1) progestogens

    Effects of Progestogens with Androgenic = Virilizing, Antiandrogenic = Feminizing, and Paradoxical Side Effects

    Androgens and Anabolics

    Concluding Remarks

    Acknowledgements:

    Chapter 6: The Maintenance of Pregnancy by Progesterone and Estrone in Rats Fed a Protein-Free Diet

    Abstract:

    Introduction

    Materials and Methods

    Results and Discussion

    Chapter 7: Effects of Brain Implants of Testosterone Propionate in Newborn Hamsters on Sexual Differentiation

    Abstract:

    Introduction

    Methods

    Chapter 8: Induction of Conditions Leading to Cancer in the Genital Tract by Estrogen During the Differentiation Phase of the Genital Epithelium

    Abstract:

    Introduction

    Arguments for an Association between Diethylstilbestrol (DES) Ingestion during Pregnancy and Clear-Cell Adenocarcinoma in the Cervix and Vagina of the Female Offspring

    Comments on the Use of DES and the Incidence of Clear-Cell Adenocarcinoma in the Population

    The Relationship between Clear-Cell Adenocarcinoma and Vaginal Adenosis

    Possible Modes for DES Influencing the Cervicovaginal Epithelium

    Conclusion

    Acknowledgements:

    Chapter 9: Androgens in Prenatal Development: Behavior Changes in Nonhuman Primates and Men

    Abstract:

    Introduction

    Nonhuman Primates: Prenatal Androgenization in Genetic Female Rhesus Monkeys

    Androgenic Effects on Human Sexually Dimorphic Behavior

    Review

    Acknowledgements:

    Chapter 10: A Comparative Endocrinological and Pharmacological View of the Maintenance or Interruption of Pregnancy

    Publisher Summary

    Introduction

    Maintenance of Pregnancy

    Abortive Effects

    Conclusion

    Acknowledgements:

    Chapter 11: Steroid Hormone Levels During Pregnancy in Various Species

    Abstract:

    Introduction

    Estrogens

    Conclusion

    Chapter 12: Ovarian Steroids in Embryonic Development Before Nidation

    Abstract:

    Introduction

    Development of the Blastocyst

    Hormone-Sensitive Proteins in Blastocyst Development

    Exogenous Estrogens Interrupt Preimplantational Development

    Exogenous Progestins are Beneficial for Preimplantational Blastocysts

    Steroids in Blastocyst-Uterine Metabolic Relationships

    Effect of Steroids on In Vitro Development

    Presence and Function of Steroids in Blastocyst Compartments

    Ovarian Hormones and Blastocyst Development at Abnormal Conditions

    Conclusion

    Acknowledgement:

    Chapter 13: Hormone Control of Early Pregnancy

    Abstract:

    Introduction

    Hormone Control of Oviductal Functions

    Hormone Control of Uterine Functions

    Acknowledgements:

    Chapter 14: Morphology of Development of the Endocrine System in Human Embryos and Fetuses

    Publisher Summary

    Acknowledgement:

    Lecturers

    Name Index

Product details

  • No. of pages: 260
  • Language: English
  • Copyright: © Pergamon 1975
  • Published: January 17, 1975
  • Imprint: Pergamon
  • eBook ISBN: 9781483151717

About the Editor

G. Raspé

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