
Hormones and Breast Cancer
Description
Key Features
- Contributions from leading authorities
- Informs and updates on all the latest developments in the field
Readership
Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested
Table of Contents
Former Editors
Contributors
Preface
Chapter One. Estrogen-Mediated Mechanisms to Control the Growth and Apoptosis of Breast Cancer Cells: A Translational Research Success Story
1 Introduction
2 Clinical Presentation of Breast Cancer
3 Targeted Therapy
4 Transition to Tamoxifen
5 Selective Estrogen Receptor Modulation
6 Acquired Drug Resistance and the Surprise of SERMs
7 Estrogen-Induced Apoptosis: Back to the Beginning
8 The Legacy of Tamoxifen
Acknowledgments
References
Chapter Two. The Epidemiology and Molecular Mechanisms Linking Obesity, Diabetes, and Cancer
1 Introduction
2 Type 2 Diabetes and Breast Cancer
3 The Role of Cholesterol in Cancer Growth
4 Obesity, Estrogen, and Breast Cancer
5 Current Medications for Type 2 Diabetes: Relationship to Breast Cancer
6 Conclusions and Future Directions
References
Chapter Three. Sex Hormone Receptors in Breast Cancer
1 Introduction
2 Historical Perspective
3 Receptor Structure and Function
4 ER Agonists and Antagonists
5 Molecular Mechanisms of Estrogen Signaling
6 Implications in Breast Cancer
7 Future Directions
References
Chapter Four. Modulation of Estrogen Receptor Alpha Activity and Expression During Breast Cancer Progression
1 Introduction
2 DNA Methylation
3 ERα Transcriptional Regulation by cis- and trans-Acting Elements
4 ERα Gene Mutations and Splice Variants
5 MicroRNA Deregulation
6 Cross Talk with Growth Factor Receptor Signaling
7 ER Posttranslational Modifications
8 Hypoxia
9 ER Coregulators
10 Breast Cancer Stem-Like Cells
11 Pioneer Factors and Endocrine-Resistant Specific Cistromes
12 Conclusions and Future Directions
Acknowledgments
References
Chapter Five. Targeting Progesterone Receptors in Breast Cancer
1 Introduction
2 Progestins and Breast Cancer Risk
3 Progestins Stimulating Breast Cancer Growth in Animal Models
4 In Vitro Studies
5 Progestins Inhibiting Breast Cancer Growth
6 The Systemic Effect of Progestins
7 PRs and Gene Expression
8 Regulation of PR Activity
9 PRs as Therapeutical Targets for Breast Cancer Treatment
Acknowledgments
References
Chapter Six. The Hyperplastic Phenotype in PR-A and PR-B Transgenic Mice: Lessons on the Role of Estrogen and Progesterone Receptors in the Mouse Mammary Gland and Breast Cancer
1 Introduction
2 Developmental Stages in the Mouse Mammary Gland
3 Spatiotemporal Expression of Estrogen and Progesterone Receptors in the Mouse Mammary Gland
4 The Generation of PR-A and PR-B Transgenic Mice
5 Breast Cancer and PRs
6 PRs and Mammary Stem Cells
7 Conclusion and Future Directions
Acknowledgments
References
Chapter Seven. FOXP1 and Estrogen Signaling in Breast Cancer
1 Introduction
2 FOXP1 and FOXA1 in ERα-Positive Breast Cancer Cells
3 Clinicopathological Significances of FOXP1 and FOXA1 in ER-Positive Breast Cancer
4 Conclusions and Future Directions
Acknowledgments
References
Chapter Eight. Role of KLF5 in Hormonal Signaling and Breast Cancer Development
1 Introduction
2 Progesterone—PR Signaling, KLF5, and Breast Cancer
3 Estrogen—ER Signaling and KLF5 in Breast Cancer
4 Androgen/AR Signaling, KLF5, and Breast Cancer
5 Summary and Perspectives
Acknowledgments
References
Chapter Nine. Dynamic Regulation of Steroid Hormone Receptor Transcriptional Activity by Reversible SUMOylation
1 Introduction
2 Mechanisms of Protein SUMOylation
3 SR SUMOylation/deSUMOylation
4 SR SUMOylation Modulates Transcriptional Action and Promoter Selectivity
5 Conclusions
References
Chapter Ten. Beta-Endorphin Neuron Regulates Stress Response and Innate Immunity to Prevent Breast Cancer Growth and Progression
1 Introduction
2 Neuroendocrine Response to Stress
3 Chronic Stress and Its Effect on Immune Functions
4 Neuroendocrine-Immune Pathway of Cancer
5 Beta-Endorphin Neurotransmission Reduces the Body’s Stress Response
6 Beta-Endorphin Neurotransmission Enhances Innate Immunity
7 Beta-Endorphin Cell Transplantation Effects on the Neuroendocrine-Immune Pathway of Cancer
8 Conclusions
References
Chapter Eleven. The Functional Role of Notch Signaling in Triple-Negative Breast Cancer
1 Background—Triple-Negative Breast Cancer and Notch
2 Notch—Breast Oncogenes
3 Notch in TNBC
4 Notch in Luminal Versus Basal-Like Breast Cancer
5 ER and Notch
6 PR and Notch
7 HER-2 and Notch
8 Prognostic Makers for Survival Associated with Notch in TNBC
9 Therapeutic Strategies in TNBC
References
Chapter Twelve. ADAM22 as a Prognostic and Therapeutic Drug Target in the Treatment of Endocrine-Resistant Breast Cancer
1 Introduction
2 ADAM Proteins in Breast Cancer
3 ADAM22 and Breast Cancer
4 A Functional Role for ADAM22
5 ADAMs as Therapeutic Targets
6 Conclusions
References
Chapter Thirteen. Alpha-Actinin 4 and Tumorigenesis of Breast Cancer
1 Introduction
2 Overview of ACTNs
3 The Function of ACTN4 in Breast Cancer
4 ACTN4 and Other Cancers
5 Conclusion and Future Direction
Acknowledgments
References
Chapter Fourteen. Adherence Rates and Correlates in Long-term Hormonal Therapy
1 Introduction
2 Nonadherence in Clinical Practice
3 Patient-Reported Barriers to Adherence to Adjuvant Hormonal Therapies
4 Interventions to Increase Adherence
5 Discussion
6 Conclusion
References
Index
Product details
- No. of pages: 424
- Language: English
- Copyright: © Academic Press 2013
- Published: June 25, 2013
- Imprint: Academic Press
- Hardcover ISBN: 9780124166738
- eBook ISBN: 9780124166769
About the Serial Editor
Gerald Litwack
