Hormones and Breast Cancer

Hormones and Breast Cancer

1st Edition - June 25, 2013

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  • Editor: Gerald Litwack
  • Hardcover ISBN: 9780124166738
  • eBook ISBN: 9780124166769

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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hormones and breast cancer.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested

Table of Contents

  • Former Editors



    Chapter One. Estrogen-Mediated Mechanisms to Control the Growth and Apoptosis of Breast Cancer Cells: A Translational Research Success Story

    1 Introduction

    2 Clinical Presentation of Breast Cancer

    3 Targeted Therapy

    4 Transition to Tamoxifen

    5 Selective Estrogen Receptor Modulation

    6 Acquired Drug Resistance and the Surprise of SERMs

    7 Estrogen-Induced Apoptosis: Back to the Beginning

    8 The Legacy of Tamoxifen



    Chapter Two. The Epidemiology and Molecular Mechanisms Linking Obesity, Diabetes, and Cancer

    1 Introduction

    2 Type 2 Diabetes and Breast Cancer

    3 The Role of Cholesterol in Cancer Growth

    4 Obesity, Estrogen, and Breast Cancer

    5 Current Medications for Type 2 Diabetes: Relationship to Breast Cancer

    6 Conclusions and Future Directions


    Chapter Three. Sex Hormone Receptors in Breast Cancer

    1 Introduction

    2 Historical Perspective

    3 Receptor Structure and Function

    4 ER Agonists and Antagonists

    5 Molecular Mechanisms of Estrogen Signaling

    6 Implications in Breast Cancer

    7 Future Directions


    Chapter Four. Modulation of Estrogen Receptor Alpha Activity and Expression During Breast Cancer Progression

    1 Introduction

    2 DNA Methylation

    3 ERα Transcriptional Regulation by cis- and trans-Acting Elements

    4 ERα Gene Mutations and Splice Variants

    5 MicroRNA Deregulation

    6 Cross Talk with Growth Factor Receptor Signaling

    7 ER Posttranslational Modifications

    8 Hypoxia

    9 ER Coregulators

    10 Breast Cancer Stem-Like Cells

    11 Pioneer Factors and Endocrine-Resistant Specific Cistromes

    12 Conclusions and Future Directions



    Chapter Five. Targeting Progesterone Receptors in Breast Cancer

    1 Introduction

    2 Progestins and Breast Cancer Risk

    3 Progestins Stimulating Breast Cancer Growth in Animal Models

    4 In Vitro Studies

    5 Progestins Inhibiting Breast Cancer Growth

    6 The Systemic Effect of Progestins

    7 PRs and Gene Expression

    8 Regulation of PR Activity

    9 PRs as Therapeutical Targets for Breast Cancer Treatment



    Chapter Six. The Hyperplastic Phenotype in PR-A and PR-B Transgenic Mice: Lessons on the Role of Estrogen and Progesterone Receptors in the Mouse Mammary Gland and Breast Cancer

    1 Introduction

    2 Developmental Stages in the Mouse Mammary Gland

    3 Spatiotemporal Expression of Estrogen and Progesterone Receptors in the Mouse Mammary Gland

    4 The Generation of PR-A and PR-B Transgenic Mice

    5 Breast Cancer and PRs

    6 PRs and Mammary Stem Cells

    7 Conclusion and Future Directions



    Chapter Seven. FOXP1 and Estrogen Signaling in Breast Cancer

    1 Introduction

    2 FOXP1 and FOXA1 in ERα-Positive Breast Cancer Cells

    3 Clinicopathological Significances of FOXP1 and FOXA1 in ER-Positive Breast Cancer

    4 Conclusions and Future Directions



    Chapter Eight. Role of KLF5 in Hormonal Signaling and Breast Cancer Development

    1 Introduction

    2 Progesterone—PR Signaling, KLF5, and Breast Cancer

    3 Estrogen—ER Signaling and KLF5 in Breast Cancer

    4 Androgen/AR Signaling, KLF5, and Breast Cancer

    5 Summary and Perspectives



    Chapter Nine. Dynamic Regulation of Steroid Hormone Receptor Transcriptional Activity by Reversible SUMOylation

    1 Introduction

    2 Mechanisms of Protein SUMOylation

    3 SR SUMOylation/deSUMOylation

    4 SR SUMOylation Modulates Transcriptional Action and Promoter Selectivity

    5 Conclusions


    Chapter Ten. Beta-Endorphin Neuron Regulates Stress Response and Innate Immunity to Prevent Breast Cancer Growth and Progression

    1 Introduction

    2 Neuroendocrine Response to Stress

    3 Chronic Stress and Its Effect on Immune Functions

    4 Neuroendocrine-Immune Pathway of Cancer

    5 Beta-Endorphin Neurotransmission Reduces the Body’s Stress Response

    6 Beta-Endorphin Neurotransmission Enhances Innate Immunity

    7 Beta-Endorphin Cell Transplantation Effects on the Neuroendocrine-Immune Pathway of Cancer

    8 Conclusions


    Chapter Eleven. The Functional Role of Notch Signaling in Triple-Negative Breast Cancer

    1 Background—Triple-Negative Breast Cancer and Notch

    2 Notch—Breast Oncogenes

    3 Notch in TNBC

    4 Notch in Luminal Versus Basal-Like Breast Cancer

    5 ER and Notch

    6 PR and Notch

    7 HER-2 and Notch

    8 Prognostic Makers for Survival Associated with Notch in TNBC

    9 Therapeutic Strategies in TNBC


    Chapter Twelve. ADAM22 as a Prognostic and Therapeutic Drug Target in the Treatment of Endocrine-Resistant Breast Cancer

    1 Introduction

    2 ADAM Proteins in Breast Cancer

    3 ADAM22 and Breast Cancer

    4 A Functional Role for ADAM22

    5 ADAMs as Therapeutic Targets

    6 Conclusions


    Chapter Thirteen. Alpha-Actinin 4 and Tumorigenesis of Breast Cancer

    1 Introduction

    2 Overview of ACTNs

    3 The Function of ACTN4 in Breast Cancer

    4 ACTN4 and Other Cancers

    5 Conclusion and Future Direction



    Chapter Fourteen. Adherence Rates and Correlates in Long-term Hormonal Therapy

    1 Introduction

    2 Nonadherence in Clinical Practice

    3 Patient-Reported Barriers to Adherence to Adjuvant Hormonal Therapies

    4 Interventions to Increase Adherence

    5 Discussion

    6 Conclusion



Product details

  • No. of pages: 424
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: June 25, 2013
  • Imprint: Academic Press
  • Hardcover ISBN: 9780124166738
  • eBook ISBN: 9780124166769

About the Serial Editor

Gerald Litwack

Gerald Litwack
Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

Affiliations and Expertise

Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine, USA; Toluca Lake, North Hollywood, California, USA

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