Description

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on hormones and breast cancer.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested

Table of Contents

Former Editors

Contributors

Preface

Chapter One. Estrogen-Mediated Mechanisms to Control the Growth and Apoptosis of Breast Cancer Cells: A Translational Research Success Story

1 Introduction

2 Clinical Presentation of Breast Cancer

3 Targeted Therapy

4 Transition to Tamoxifen

5 Selective Estrogen Receptor Modulation

6 Acquired Drug Resistance and the Surprise of SERMs

7 Estrogen-Induced Apoptosis: Back to the Beginning

8 The Legacy of Tamoxifen

Acknowledgments

References

Chapter Two. The Epidemiology and Molecular Mechanisms Linking Obesity, Diabetes, and Cancer

1 Introduction

2 Type 2 Diabetes and Breast Cancer

3 The Role of Cholesterol in Cancer Growth

4 Obesity, Estrogen, and Breast Cancer

5 Current Medications for Type 2 Diabetes: Relationship to Breast Cancer

6 Conclusions and Future Directions

References

Chapter Three. Sex Hormone Receptors in Breast Cancer

1 Introduction

2 Historical Perspective

3 Receptor Structure and Function

4 ER Agonists and Antagonists

5 Molecular Mechanisms of Estrogen Signaling

6 Implications in Breast Cancer

7 Future Directions

References

Chapter Four. Modulation of Estrogen Receptor Alpha Activity and Expression During Breast Cancer Progression

1 Introduction

2 DNA Methylation

3 ERα Transcriptional Regulation by cis- and trans-Acting Elements

4 ERα Gene Mutations and Splice Variants

5 MicroRNA Deregulation

6 Cross Talk with Growth Factor Receptor Signaling

7 ER Posttranslational Modifications

8 Hypoxia

9 ER Coregulators

10 Breast Cancer Stem-Like Cells

11 Pioneer Factors and Endocrine-Resistant Specific Cistromes

12 Conclusions and Future Directions

Acknow

Details

No. of pages:
424
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Print ISBN:
9780124166738
Electronic ISBN:
9780124166769