Hormonal Steroids

Hormonal Steroids

Proceedings of the Sixth International Congress on Hormonal Steroids

1st Edition - January 1, 1983

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  • Editors: V. H. T. James, J. R. Pasqualini
  • eBook ISBN: 9781483190679

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Hormonal Steroids presents the proceedings of the Sixth International Congress on Hormonal Steroids, held in Jerusalem, Israel in September 1982. The book covers a wide range of topics on the field of hormonal steroids research. The topics discussed include the history of steroid-protein interaction; enzyme induction by estrogen; steroids and the immune system; correlative morphological and biochemical investigations on the stromal tissue of the human prostate; analysis of intact steroid conjugates by secondary ion mass spectrometry (including fabms) and by gas chromatography; and the role of lipoproteins in steroidogenesis by human luteinized granulosa cells in culture. Biochemists, pathologists, pharmacologists, and medical and pharmaceutical researchers will find the book a good source of insight.

Table of Contents

  • Plenary Lectures

    Steroid-Protein Interaction: From Past to Present

    Hormonal Interactions in the Control of Granulosa Cell Differentiation

    Enzyme Induction by Estrogen

    The Hormonal and Cellular Control of Sertoli Cell Secretion


    1. Estrogen Antagonists

    Aromatase Inhibitors, Their Pharmacology and Application

    Antiestrogen Pharmacology and Mechanism of Action

    Cellular and Molecular Mechanism of Action of Antiestrogens

    Guide-Lines in the Design of New Antiestrogens and Cytotoxic-Linked Estrogens for the Treatment of Breast Cancer

    2. Mechanism of Steroid Action

    Immunoreactivity of the Core of Estrogen Receptors Found in Different Subcellular Compartments of Target Cells from a Variety of Mammalian Species

    Eosinophil-Mediated Non-Genomic Parameters of Estrogen Stimulation - A Separate Group of Responses Mediated by an Independent Mechanism

    Enhanced Transcription of RRNA Genes by Purified Androgen Receptor Complexes In Vitro

    Specific Cell Adhesion to Estradiol-Derivatized Agarose Beads

    3. Ovarian Function: Follicle

    The Endrocrine Control of Follicle Androgen Biosynthesis

    Acute Stimulatory Effects of Luteinizing Hormone-Releasing Hormone (LHRH) and LHRH Analogues on the Preovulatory Rat Follicle

    The Actions of Follicular Fluid Factors on Steroidogenesis by Cultured Ovarian Granulosa Cells

    The Role of Steroid Signals in the Maturation of Mammalian Oocytes

    Steroidal and Peptidic Control Mechanisms in Membrane of Xenopus Laevis Oocytes Resuming Meiotic Division

    4. Steroid Pathophysiology of BPH

    Correlative Morphological and Biochemical Investigations on the Stromal Tissue of the Human Prostate

    Androgens and Estrogens: Their Interaction with Stroma and Epithelium of Human Benign Prostatic Hyperplasia and Normal Prostate

    Progestin Binding in Benign Hyperplastic Prostatic Tissue

    Kinetic Analysis of 5α-Reductase Isoenzymes in Benign Prostatic Hyperplasia (BPH)

    5. Analytical Methods: Physicochemical Assays

    Use of Ion Exchange Chromatography in Steroid Analysis

    Recent Applications of N.M.R. to the Investigation of Steroid Structures

    Selective Reactions in the Analytical Characterization of Steroids by Gas Chromatography-Mass Spectrometry

    Special Uses of a Gas Chromatograph-Mass Spectrometer is Endocrinology

    Analysis of Intact Steroid Conjugates by Secondary Ion Mass Spectrometry (Including FABMS) and by Gas Chromatography

    6. Steroid Metabolism in Neuroendocrine Structures

    Specific and Nonspecific Components in the Oxidative Metabolism of Estradiol by the Male Rat Brain In Vitro

    Is the 5α-Reductase of the Hypothalamus and of the Anterior Pituitary Neurally Regulated? Effects of Hypothalamic Deafferentations and of Centrally Acting Drugs

    5α-Dihydrotestosterone Formation and Its Functional Significance in Rat Anterior Pituitary, Subpopulations of Gonadotrophs and Cell Cultures

    Binding and Effects of 5α-Androstane-3ß,17ß-Diol in the Male Rat Pituitary

    7. Corticosteroid Secretion—Clinical Aspects

    Plasma Cortisol Concentrations in the Functional Psychoses and Alzheimer Type Dementia: A Neuroendocrine Day Approach in Drug-Free Patients

    The Dexamethasone Suppression Test in Depressed Patients: Clinical and Biochemical Aspects

    Rapid Corticosterone Pulses

    Salivary Steroid Assays for Assessing Variation in Endocrine Activity

    Quantitative Characterization of ACTH and Adrenocortical Episodic Secretion in Man: An Introduction

    8. Steroids and Differentiation

    The Role of Estrogen in the Differentiation of Prolactin Producing Cells

    The Modulation of Decidual Cells Proliferation and Differentiation by Progesterone and Prostaglandins

    Interactions between Hormones and Growth Factors in the Regulation of Granulosa Cell Differentiation In Vitro

    9. Steroid Receptors

    Correlation of Estrogen and Progesterone Receptor Status with Ultrastructural Differentiation in Breast Tumors

    Development of Responsiveness to Glucocorticoid Hormones

    Steroid Receptor Forms and Their Interaction with Cytoplasmic Modulators

    Corticosteroid Binder IB: A Model of Glucocorticoid Receptor Diversity

    10. Hypertension

    A Comparison of the Effects of Angiotensin II Infusion and Variations in Salt Intake on Plasma Aldosterone Levels in Normal Subjects, Patients with Essential Hypertension and Patients with Hyperaldosteronism

    Arterial Steroid Receptors and Their Putative Role in the Mechanism of Hypertension

    Aldosterone Metabolites and Possible Aldosterone Precursors in Hypertension

    19-Hydroxyandrostenedione: A Potent Hypertensinogenic Steroid in Man

    11. Testicular and Epididymal Function

    Effects of Isolation and Purification Procedures on the Viability and Properties of Testis Leydig Cells

    The Role of Phosphoproteins and Newly Synthesized Proteins in the Hormonal Regulation of Steroidogenesis in Leydig Cells

    Hormonal Regulation of Pig Leydig Cells in Culture

    12. Androgens: Pharmacodynamics and Antagonists

    Biochemical and Biological Studies with 4-Aza-Steroidal 5α-Reductase Inhibitors

    Pharmacological Basis for Clinical Use of Antiandrogens

    13. Analytical Methods: Immunoassays

    Problems of Validity in Steroid Immunoassays

    Preparation and Evaluation of Steroid Chemiluminescent Tracers

    Development of Chemiluminescence Monitored Immunoassays for Steroid Hormones

    Penicillinase as a Marker in Enzyme-Linked Immunosorbent Assays for Steroid Hormones

    Steroid Determination in Milk by Enzyme Immunoassay (EIA)

    On Some Useful Statistical Techniques in the Analysis of Hormone Data

    14. Effects on CNS and Anterior Pituitary Function

    Effects of Anterior Pituitary Hormones and Their Releasing Hormones on Physiological and Behavioral Functions in Rats

    Multiple Factors Involved in the Control of ACTH and α-MSH Secretion

    Effects of Estradiol Benzoate and Castration on LH in Experimental Hyperprolactinemia

    Influence of Adrenalectomy and Ovariectomy on Gonadrophin Secretion

    15. Steroids and the Immune System

    The Interrelationship of the HPG-Thymic Axis and Immune System Regulation

    Epithelial Cell Involvement in the Estradiol-Stimulated Accumulation of IgA in the Rat Uterus

    Glucocorticoid Receptors of Wild-Type and Variant Mouse Lymphoma Cells

    Glucocorticoid Induced Cytolysis of Human Normal and Malignant Lymphocytes

    16. Testicular and Epididymal Function-II

    Effect of GNRH Superactive Analogs (Alone and Combined with Androgen) on Testicular Function in Man and Experimental Animals

    Chemical Messengers Between Sertoli Cells and Neighbouring Cells

    17. Vitamin D: Clinical Aspects

    Circulating Levels and Function of L,25-(OH)2 D3 in Lactation

    Follow-Up of Long-Term Treatment of Predialysis Renal Bone Disease with 1-α-Hydroxy-Derivatives of Vitamin D

    Chronic Renal Failure and Vitamin D Metabolites: A Status Report

    18. Control of Corticosteroid Secretion

    Regulation of Aldosterone Secretion during Altered Sodium Intake

    Effect of Metergoline on the Aldosterone-Stimulating Properties of Metoclopramide

    α-MSH and Zona Glomerulosa Function in the Rat

    Glucocorticoid Secretion: A Circadian Synchronizer of the Human Temporal Structure

    19. Steroid Resistance

    Possible Mechanisms of Androgen Resistance in 5α-Reductase Deficiency: Implications for the Physiological Roles of 5α-Reductases

    Possible Implications of the Comparative Dissociative Behavior of Testosterone- and 5α-Dihydrotestosterone-Receptor Complexes Formed by Human Skin Fibroblasts

    Primary Cortisol Resistance: A Familial Syndrome and an Animal Model

    Residual Androgen Binding in Testicular Feminization (TFM)

    Fibroblast Studies on Clinical Androgen Insensitivity

    20. Steroids and Skin

    Steroid Inhibitors of Androgen-Potentiated Actions on Skin

    Antiandrogens in the Treatment of Acne and Hirsutism

    Transformation of Dehydroepiandrosterone into Dihydrotestosterone by Isolated Cells from Rat Preputial Gland

    A Comparison of Androgen Production and Clearance in Hirsute and Obese Women

    21. Catechol Estrogens

    Catecholestrogens in the Brain: Neuroendocrine Integration

    Catechol Estrogens and the Control of Gonadotropin and Prolactin Secretion in Man

    Radioimmunoassay and Metabolic Clearance Rate of Catecholestrogens, 2-Hydroxyestrone and 2-Hydroxyestradiol in Man

    The Role of 2-Methoxyesterone in Estrogen Action

    Possible Mechanism of Action of 2-Hydroxylated Estradiol on the Positive Feedback Control of LH Release in the Rat

    22. Congenital Adrenal Hyperplasia and Sexual Dimorphism

    Diagnosis of Homozygosity and Heterozygosity in Congenital Adrenal Hyperplasia (CAH) and Control of Treatment

    Suppression and Stimulation of Mineralocorticoid Hormones (MCH) in the Simple Virilizing Form of Congenital Adrenal Hyperplasia (CAH) Evaluated by the Quantitation in Adrenal Venous Blood

    Male Pseudohermaphroditism Due to 17ß-Hydroxysteroid Dehydrogenase Deficiency: Studies on the Natural History of the Defect and Effect of Androgens on Gender Role

    Apparent Double Defect in C11ß and C21-Steroid Hydroxylation in Congenital Adrenal Hyperplasia

    23. Metabolism of Androgens

    Metabolism in Vitro of Testosterone (T) to 17ß-Hydroxy-5α-Androstane-3-One (DHT) and 5α-Androstane-3α,17ß-Diol (3α) by the 800g Supernatant Fraction of Ileum from Rats

    Aromatization of Steroids in Peripheral Tissues

    Regulation of Sexually Dimorphic Hepatic Steroid Metabolism by the Somatostatin-Growth Hormone Axis

    Current Status of the Molecular Structure and Function of the Plasma Sex Steroid-Binding Protein (SBP)

    Aromatization of Androgens by Human Adipose Tissue in Vitro

    24. Rhythms

    Effect of Diet and Season on Steroid Hormones in the Ruminant

    Seasonal Effect on Steroids in Blood Plasma and Seminal Plasma of Boars

    The Annual Reproductive Cycle in Mallards

    Ontogeny of an Oscillation Underlying the Circadian Rhythm of Plasma Corticosterone in Rats

    25. Sex Steroid Induced Proteins

    Properties of an Estrogen-Induced Hydrolytic Enzyme from Mouse Uterus

    A Progestagen-Associated Protein of the Human Endometrium: Basic Studies and Potential Clinical Applications

    26. New Steroids: Synthesis and Structure/Activity Relationships

    A New Series of Steroidal Antidysrhythmic Agents

    New Routes to A-Ring Substituted Estrogens

    Synthesis and Activities of Anti-Aldosterones

    5-Chloro-5ß-Cholestane, the First Simple 5ß-Chlorosteroid

    Recent Developments in Corticoid Synthesis

    27. Ovarian Function: Corpus Luteum

    Purine Modulation of LH Action in Gonadal Cells

    Gonadotropin and Lipoprotein Receptor Levels in Rat Luteal Cells of Early Pregnancy

    The Role of Calcium Ion in Luteal Function in the Rat

    Interrelation Between Luteal Cell Types in Steroidogenesis In Vitro of Human Corpus Luteum

    28. Pharmacology and Pharmacodynamics of Contraceptive Steroids

    Variability of Pharmacokinetic Parameters for Contraceptive Steroids

    Drug Effects on the Intestinal Absorption of Estrogens

    29. Steroid Receptors As Predictors of Cancer Response

    Female Sex Steroid Receptors in Gynecological Malignancies: Clinical Correlates

    Steroid Receptors as a Guide for Therapy of Primary and Metastatic Breast Cancer

    The Significance of Lectin Receptors for the Evaluation of Hormone Dependence in Breast Cancer

    Present Concept of the Relevance of Steroid Receptors for Prostatic Cancer

    Significance of Glucocorticoid Receptors and Responses in Leukemia

    30. Monitoring and Control of Reproductive Cycle in Ruminants

    Fertility of Dairy Cattle Following Oestrous and Ovulation Controlled with Cloprostenol, Oestradiol Benzoate and Progesterone Or Progesterone and Cloprostenol

    The Effect of Dietary and Climatic Factors on Fertility, and on Plasma Progesterone and Oestradiol-17ß Levels in Dairy Cows

    The Induction of Oestrous and Ovulation in Seasonally Anovular Ewes by Exposure to Rams

    Oestrogens in Milk

    31. Puberty

    Blood Concentrations and Biological Effects of Androstanediols at the Onset of Puberty in the Female Rat

    On the Significance of 5α-Androstane-3α,17ß-Diol in the Peripubertal Female Rat

    Correlations Between Plasma Levels of Opioid Peptides and Adrenal Androgens in Prepuberty and Puberty

    Steroid Secretion by the Prepubertal Human Testis

    The Role of Thyrotrophin Releasing Hormone in the Diagnosis of Isolated Gonadotrophin Deficiency

    32. Vitamin D: Basic Aspects

    Synthesis and Biological Activity of Vitamin D3 Analogues

    Possible Significance of New Target Tissues for 1,25-Dihydroxyvitamin D3

    Radiochemical Assays for Vitamin D Metabolites: Technical Possibilities and Clinical Applications

    33. Endogenous Androgens in Tissues

    Regulation and Compartmentalization of Androgens in Rat Prostate and Muscle

    Subcellular Distribution of Androgens and Oestrogens in Target Tissue

    Use of Radioimmunoassay Procedures for the Determination of Sex Hormones in Animal Tissues

    Steroid Biosynthesis by Zona Fasciculata and Zona Reticularis Cells Purified from the Mammalian Adrenal Cortex

    Testicular Testosterone and Dihydrotestosterone during Sexual Development in Humans

    34. Steroids and Early Development

    Role of FSH and Oestradiol-17ß in the Development of Meiotic Competence in Rat Oocytes

    Embryonic Steroid Synthesis and Luteal Oxytocin Production: Controlling Mechanisms for the Maternal Recognition of Pregnancy

    35. Steroid Rhythms and Disorders Related to Aging

    Hormone Production by the Early Bovine Embryo

    Altered Androgen Regulation of Differentiated Ventral Prostate Function During Aging of the AXC Rat

    Suppression of Testicular Steroidogenesis by the GnRh Agonistic Analogue Buserelin (HOE-766) in Patients with Prostatic Cancer: Studies in Relation to Dose and Route of Administration

    New Hormonal Treatment in Cancer of the Prostate: Combined Administration of an LHRH Agonist and an Antiandrogen

    CNS Control of the Circadian Adrenocortical Rhythm

    36. Control of Cholesterol Metabolism in Steroidogenic Tissues

    Cholesterol Metabolism in the Adrenal Cortex

    The Role of the Phosphatidate-Inositide Cycle in the Action of Steroidogenic Agents

    The Role of Lipoproteins in Steroidogenesis by Human Luteinized Granulosa Cells in Culture

    Forthcoming Papers

    Papers Published in Biochimie


Product details

  • No. of pages: 1070
  • Language: English
  • Copyright: © Pergamon 1983
  • Published: January 1, 1983
  • Imprint: Pergamon
  • eBook ISBN: 9781483190679

About the Editors

V. H. T. James

J. R. Pasqualini

Affiliations and Expertise

CNRS Steroid Hormone Research Unit, Foundation for Hormone Research, 26 Boulevard Brune, 75014 Paris, France

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