Hormonal Steroids

Hormonal Steroids

Proceedings of the Fifth International Congress on Hormonal Steroids

1st Edition - January 1, 1979

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  • Editors: V. H. T. James, J. R. Pasqualini
  • eBook ISBN: 9781483158952

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Description

Hormonal Steroids contains the plenary and symposium lectures delivered to the Fifth International Congress on Hormonal Steroids held at New Delhi on October 30 to November 4, 1978. The plenary lectures include biochemical actions of trophic hormones and steroids on steroid production and spermatogenesis in testes; chemical reactions of steroids which imitate the selectivity of enzymatic transformations; and human chorionic gonadotrophin and ovarian and placental steroidogenesis. Symposia papers comprise of water-soluble steroidal anesthetics; quality control of radioimmunoassay of hormones in reproductive physiology; automation of steroid radioimmunoassay for clinical and research purposes; non-radioisotopic homogeneous steroid immunoassays; mechanisms involved in the regulation of steroid receptor levels; and metabolic effects of corticosteroid therapy in post-menopausal women.

Table of Contents


  • Contents

    Plenary Lectures

    Gregory Pincus and Steroidal Contraception: A New Departure in the History of Mankind

    The Testes: Biochemical Actions of Trophic Hormones and Steroidson Steroid Production and Spermatogenesis

    Chemical Reactions of Steroids Which Imitate The Selectivity of Enzymatic Transformations

    Human Chorionic Gonadotrophin and Ovarian and Placental Steroidogenesis

    Recent Advances in Our Understanding of the Vitamin D Endocrine System

    Symposia

    1. Advances in Steroid Chemistry

    Total Synthesis of Natural and Non-Natural Steroid Hormones

    Synthesis and Structure-Activity Relationships in A Novel Series of Topically Active Corticosteroids

    Seco-Oestradiols and Some Non-Steroidal Oestrogens: Structural Correlates of Oestrogenic Action

    Water-Soluble Steroidal Anaesthetics

    2. Steroid Antagonists

    Steroid Antagonists: Pharmacological Effects, and Physiological Roles?

    Action of A Non-Steroid Anti-Androgen, RU 23908, in Peripheral and Central Tissues

    A Critical Appraisal of the Effects of the Antiandrogen, Cyproterone Acetate, On The Epididymis in Connection With Fertility Control Inthe Male

    Aromatase Inhibitors and Their Use in Controlling Oestrogendependent Processes

    3. Analytical Methods

    Quality Control of Radioimmunoassay of Hormones in Reproductive Physiology

    Determination of Steroid Hormones by The Use of Isotope Dilutionmass Spectrometry: A Definitive Method in Clinical Chemistry

    Automation of Steroid Radioimmunoassays For Clinical and Research Purposes

    General and Selective Isolation Procedures For GC/MS Analysis of Steroids in Tissues and Body Fluids

    4. New Methods of Steroid Analysis

    On The Assessment of Validity of Steroid Radioimmunoassays

    Urinary and Plasma Testosterone Glucosiduronate Measurement by A Simple RIA Method

    Enzyme-Immunoassay of Steroids: Possibilities and Pitfalls

    Selected Ion Monitoring; A New Approach for the Specific Determination of Steroids in the Lower Picogram Range

    Non-Radioisotopic Homogeneous Steroid Immunoassays

    5. Steroid Synthesis in Isolated Cells

    Properties of Dispersed Cells From Rat Adrenals

    Steroid Profiles Formed by Rat Adrenocortical Whole Tissue and Cell Suspensions Under Different Conditions of Stimulation

    Steriodogenesis in Testicular Cells

    Steroid Biosynthetic Lesions in Gonadotropin-Desensitized Leydig Cells

    6. Steroid-Enzyme Repression/Induction

    Induction of Steroid Glucuronyltransferase and Repression of Hydroxysteroid Oxidoreductase: Recent Findings

    Androgen-Dependent Synthesis of A Prostatic Binding Protein by Rat Prostate

    Effect of Testosterone, Its 5α-Reduced Metabolites and The Corresponding Propionates On Testosterone Metabolism. I—in the Hypothalamus and in the Anterior Pituitary

    Effect of Testosterone, Its'5α-Reduced Metabolites and The Corresponding Propionates On Testosterone Metabolism. II—in the Ventral Prostate and in Seminal Vesicles

    Occurrence of Steroidal Allyl Alcohols in Normal Mammary Tissues N Vitro, in Relation To Experimental Mammary Tumours

    Multiple Response Patterns To Oestrogenic Stimulation in the Avian Liver

    7. Steroid-Protein Interactions

    Oestrogen Binding Function of Alpharfetoprotein

    The Serum Sex Steroid-Binding Protein. Purification, Characterization and Immunological Properties of the Human and Rabbit Proteins

    Further Characterization and Immunological Studies of Human Sex Steroid Binding Plasma Protein

    Binding of Androgens and Progestins in the Human Testis

    8. Steroid Receptors: Biosynthesis, Biorhythms

    Relationship Between Cytosol and Nuclear Oestrogen Receptors and Oestrogen Concentrations in the Fetal Compartment of Guinea-Pig

    Mechanisms Involved in the Regulation of Steroid Receptor Levels

    Oestradiol Plus Receptor Complexes in the Brain and Anterior Pituitary Gland: Quantitation and Neuroendocrine Significance

    Effect of Oestradiol Benzoate, Tamoxifen and Monohydroxytramoxifen On Immature Rat Uterine Progesterone Receptor Synthesis and Endometrial Cell Division

    Steroid Receptors in Exocrine Glands: The Pancreas and Prostate

    9. Receptors: Purification and Properties

    Purification and Properties of Native Oestradiol Receptor

    Chicken Oviduct Nuclear Oestrogen Receptors: Aspects of Steroid Hormone Action

    The Effects of Antioestrogens On The Oestrogen Receptor

    Purification of Glucocorticoid Receptors From Rat Liver Cytosol. Preparation of Antibodies Against The Major Receptor Proteins and Application of Immunological Techniques To Study Activation and Translocation

    Antibodies To Estrophilin: Comparison Between Rabbit and Goat Antisera

    10. Receptor-Genome Interaction

    Incorporation of Steroid Hormones in Nuclei of Different Ploidy and Different Phases of the Cell Cycle

    Regulation of Transcription of the Prostate Genome by Androgens

    Control by Oestrogen of Reversible Gene Expression: The Vitellogenin Model

    Support For Chromatin Acidic Proteins As Acceptors For Progesterone in the Chick Oviduct

    Regulation of Transcription in Rat Thymus Cells by Glucocorticoids

    The Structure and Regulatory Function(S) of Cortisol Receptor—1: Extragenomic Effects Dependent On The Cortisol Receptor Activation

    11. Receptors: Non-Genome Aspects

    Prostate α-Protein: Subunit Structure, Polyamine Binding, and Inhibition of Nuclear Chromatin Binding of Androgen-Receptor Complex

    Uterine Progesterone After Progesterone Treatment: On The Disappearance of Cytosolic Progesterone Receptors

    Stabilization of the Avian Progesterone Receptor by Inhibitors

    The Role of Eosinophil Receptors in the Non-Genomic Response To Oestrogens in the Uterus

    12. Effects of Steroid Therapy

    Oral Contraceptives and Plasma Protein Metabolism

    Metabolic Effects of Corticosteroid Therapy in Post-Menopausal Women

    The Steroid-Cancer Hypothesis and Recent Pertinent Epidemiological Studies

    13. Sustained Release Preparations for the Delivery of Fertility Regulating Agents

    Improved Long-Acting Fertility Regulating Agents: What Are The Problems?

    Biodegradable Systems for the Sustained Release of Fertility-Regulating Agents

    Pharmacokinetics and Pharmacodynamics of Sustained Release Systems

    Intravaginal and Intracervical Devices for the Delivery of Fertility Regulating Agents

    Values of Steroidal Intrauterine Contraception For Developing Countries

    14. Oral Contraceptives and Nutrition

    The Effects of Depo-Provera On Carbohydrate, Lipids and Vitamin Metabolism

    The Effects of Oral Contraceptives On Carbohydrate, Lipid, and Protein Metabolism in Subjects With Altered Nutritional Status and in Association With Lactation

    Oral Contraceptive Use and Vitamin Nutrition Status of Malnourished Women—Effects of Continuous and Intermittent Vitamin Supplements

    15. Steroids in Parturition and Pregnancy

    Control of Placental Endocrine Function; Role of Enzyme Activation in the Onset of Labour

    Maternal Plasma Total Oestriol and Dehydroepiandrosterone Sulfate Loading Test As Indicators of Feto-Placental Function Or Placental Sulfatase Deficiency

    Cortisol and Cortisone in Human Fetal Development

    Steroids in Pregnancy and Parturition in the Marsupial, Macropus Eugenii

    Metabolism of Fetal and Neonatal Adrenal Steroids

    16. Perinatal Steroid Endocrinology

    Sex Differences in Serum LH and FSH Patterns in Hamsters Exposed To Short Photoperiod

    Influence of Intrahypothalamic Implants of Antioestrogen Or Aromatase Inhibitor On Development of Sterility Following Neonatal Androgenization in Female Rats

    Plasma Androgens (Testosterone and 4-Androstenedione) and 17-Hydroxyprogesterone in the Neonatal, Prepubertal and Peripubertal Periods in the Human and The Rat: Differences Between Species

    Perinatal Regulation of Cortisol in the Primate

    Hormonal Steroids, Neurbtransmitters and Sexual Differentiation of the Brain

    17. Puberty

    Sequential Hormonal Changes and Activation of the Hypothalamicpituitary-Gonadal Axis

    Changes Throughout Puberty in Adrenal Secretion After ACTH

    Interactions of Gonadal Steroids, Gonadotropins and Gonadotropin-Releasing Hormones in Sexual Maturation

    Role of Sex Steroids in the Initiation of Puberty

    Changes in Pathways of Steroid Production Taking Place in the Rat Ovary Around The Time of the First Ovulation

    18. Steroids and Human Prostatic Tumours

    C1902-Steroid Transformations in the Human Normal, Hyperplastic and Cancerous Prostate

    Testosterone 5α-Reductase and The Accumulation of Dihydrotestosterone in Benign Prostatic Hyperplasia

    A Comparative Study of Binding, Metabolism and Endogenous Levels of Androgens in Normal, Hyperplastic and Carcinomatous Human Prostate

    Metabolism and Action of Steroid Hormones On Human Benign Prostatic Hyperplasia and Prostatic Carcinoma Grown in Organ Culture

    Steroid Levels in Cancer of the Prostate—Markers of Tumour Differentiation and Adequacy of Anti-Androgen Therapy

    19. Metabolic Defects

    Male Pseudohermaphroditism Secondary To 5α-Reductase Deficiency—A Model for the Role of Androgens in Both The Development of the Male Phenotype and The Evolution of A Male Gender Identity

    Steroid Sulphatase Deficiency

    Mechanisms Establishing The Mineralocorticoid Hormone Patterns in the 17α-Hydroxylase Deficiency Syndrome

    20. Steroids in Male Reproduction

    The Role of Testosterone and Other Hormones in Regulation of LH

    Suppression of Human Spermatogenesis by Depot Androgen: Potential For Male Contraception

    Quantitative Determination of Specific Proteins in Rat Epididymis

    Studies With Cyproterone Acetate For Male Contraception

    Epididymal and Testicular Enzymes As Monitors For Assessment of Male Antifertility Drugs

    Immunological Induction of Aspermatogenesis

    21. Ovum Maturation

    Control Mechanisms in Oocyte Growth and Maturation

    Some Aspects of Oocyte Maturation in Catfish

    Roles of Cyclic AMP and Calcium in Maturation of Xenopus Laevis Oocytes

    Control of Chromosome Behavior During Progesterone Induced Maturation of Amphibian Oocytes

    22. Ovum Implantation

    Origin of Oestrogen in Preimplantation Rabbit Blastocysts

    Hormonal Control of Implantation: A Possible Role of Lysosmal Function in the Embryo-Uterus Interaction

    The Uterus During Progestation: Hormonal Modulation of Pyridine Nucleotide Activity in Relation To Decidual Sensitivity

    Experimental Models in the Search For Antigestagenic Compounds With Menses-Inducing Activity

    Blastocyst Oestrogen: An Essential Factor for the Control of Implantation

    23. Steroidogenesis in Granulosa Cells and Corpus Luteum

    The Production of Progesterone, Androgens and Oestrogens by Human Granulosa Cells in Vitro and in Vivo

    Intraovarian Control of Progesterone Biosynthesis by Granulosa Cells and Corpus Luteum

    Control of Steroidogenesis in the Preovulatory Rat Follicle

    Granulosa-Thecal Cell Interaction in Ovarian Steroidogenesis

    24. Steroid Action in CNS and Anterior Pituitary—1

    Steroid Hormone Target Cells in the Extrahypothalamic Brain Stem and Cervical Spinal Cord: Neuroendocrine Significance

    Association of Tritiated Ovarian Steroids With The Rhesus Monkey Brain

    Androgen Metabolism, Androgen and Oestrogen Receptors in the Male Rat Anterior Pituitary

    Effects of S-Triazine Herbicides On Hormone-Receptor Complex Formation, 5α-Reductase and 3α-Hydroxysteroid Dehydrogenase Activity At The Anterior Pituitary Level

    25. Steroid Action in CNS and Anterior Pituitary—II

    Functional and Organizational Aspects of Gonadal Steroids in the Pig Brain

    Nuclear Progesterone Receptors and Characterization of Cytosol Receptors in the Rat Hypothalamus and Anterior Hypophysis

    Interaction of Oestrogen and of Physiological Progesterone Metabolites in the Control of Gonadotropin Secretion

    in Vivo Uptake and Metabolism of [3H]-Progesterone and [3H]-5α-Dihydroprogesterone by Rat CNS and Anterior Pituitary: Tissue Concentration of Progesterone Itself Or Metabolites?

    Oestrogen-Progestin Regulation of Female Sexual Behavior in Guinea-Pigs

    26. Steroids and Aging

    Effects of Oestradiol On Covalent Modifications of Chromosomal Proteins and Transcription of Chromatin of the Brain of Rats of Various Ages

    Changes in the Mechanisms of Steroid Action During Aging

    Human Testicular Secretion With Increasing Age

    Factors Affecting Sex Hormone Levels in Postmenopausal Women

    The Conversion of Androstenedione To Oestrone and Production of Oestrone in Women With Endometrial Cancer

    27. Anabolic Steroids

    Detection of Anabolic Steroid Administration To Athletes

    Aspects On The Formation and Detection of Tissue Levels of Anabolic Steroids in Domestic Animals

    Anabolic Steroid Metabolism in Skeletal Muscle

    The Efficacy and Mechanism of Action of Anabolic Agents As Growth Promoters in Farm Animals

    Role of Anabolic Steroids in the Hormonal Regulation of Skeletal Muscle Adaptation

    Practical Aspects of Screening of Anabolic Steroids in Doping Control With Particular Accent To Nortestosterone Radioimmunoassay Using Mixed Antisera

    28. Photoperiodic Control of Steroid Production and Action

    Photoperiodic Control of Testosterone Metabolism in the Central and Peripheral Structures of Avian Species

    Photoperiodic Control of Androgen Metabolism and Binding in Androgen Target Organs of Hamsters (Phodopus Sungorus)

    Pineal Gland and Sympathetic Cervical Ganglia As Sites For Steroid Regulation of Photosensitive Neuroendocrine Pathways

    29. Biological Effects of Steroid Antibodies

    Antibodies To Androgens, and Ovulation in the Ewe

    Prevention of Implantation by Antiprogesterone

    Corticosteroid and Corticosteroid Metabolite Levels in Animals Immunized Against Corticosteroids

    30. Central Control of Steroid Production

    Regulation of Gonadal Steroid Rhythms in Rats

    Hormonal Modification Induced by Chronic Stress in Rats

    Evidence for the Existence of Extra-Hypophyseal Neural Mechanisms Controlling Ovarian Steroid Secretion

    Role of the Amygdala and The Organum Vasculosum Laminae Terminalis in the Control of Ovarian Function in the Female Rat

    Central Sites Controlling Pituitary Secretion in the Rhesus Monkey

    31. Steroids and Hypertension

    Adrenocortical Steroid Hormones in Production of Hypertension in Sheep

    Genetic Aspects of Plasma Aldosterone Binding Globulins in Families of Patients With Essential Hypertension, Including Isolation of Novel Thermostable Homologues From Plasma and Urine

    The Interaction of Sodium and Potassium Status, of ACTH and of Angiotensin 2 in the Control of Corticosteroid Secretion

    Adrenal Sensitivity To Angiotensin II and Undiscovered Aldoster-One Stimulating Factors in Hypertension

    32. Diagnostic Relevance of Steroid Assays

    Progress Towards The Wider Use of Better Steroid Immunoassays

    Diagnostic Relevance of Oestrogen Estimations in Human Pregnancy

Product details

  • No. of pages: 1098
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: January 1, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483158952

About the Editors

V. H. T. James

J. R. Pasqualini

Affiliations and Expertise

CNRS Steroid Hormone Research Unit, Foundation for Hormone Research, 26 Boulevard Brune, 75014 Paris, France

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