Hormonal Steroids Biochemistry, Pharmacology, and Therapeutics

Hormonal Steroids Biochemistry, Pharmacology, and Therapeutics

Proceedings of the First International Congress on Hormonal Steroids

1st Edition - January 1, 1964

Write a review

  • Editor: L Martini
  • eBook ISBN: 9780323144650

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Hormonal Steroids: Biochemistry, Pharmacology, and Therapeutics, Volume I focuses on various research on steroids and their biological and medical involvements. Comprised of 60 chapters, the book presents the literature of various authors who have conducted research on the relationship between hormonal steroids and biochemistry, pharmacology, and therapeutics. The discussions start with the identification of steroids with hormone-like activities. This discussion includes the nature, compositions, properties, possible uses, and reactions of these hormones when exposed to different conditions and controlled environments. The book then proceeds with discussions on synthesis and metabolism of hormonal steroids. These discussions are supported by graphical representations, reviews, recommendations, and methodologies. The book then explains the control of synthesis and release of steroid hormones. This part notes the relationship of renal and adrenal hormones; the control and production of corticosterone; neurosecretion and control of the pituitary gland; and release of ovulating hormones. The book also highlights the mechanism of steroid action, noting the probable interrelationships of steroids, nonsteroids, intermediary metabolism, and inflammation. Various research are presented on the possible clinical applications of steroids. The text is a vital reference for readers who are interested in the study of hormones.

Table of Contents

  • Contributors to Volume 1


    Contents of Volume 2

    Symposium 1 New Steroids With Hormone-Like Activities

    Inverted Steroids, their Preparation and Biological Activities

    Ether Derivatives of Steroidal Hormones

    Discussion. The Influence of Enol Etherification on the Biological Activity of Δ4-3-Ketosteroids

    New Steroids with Hormone-Like Activities: C-6 Substituted Hormone Analogs

    Discussion. Pharmacological Aspects of the Study of Chlormadinone

    Antiandrogenic, Antiestrogenic and Antiovulatory Compounds


    The Actions of "Retro" Progestagens

    Discussion. Possible Uses of Retrosteroid Derivatives in Humans

    Biological Properties of 4-Hydroxy-3-Keto-Δ4-Steroids

    Discussion. Applications of Ring A Modifications of 4-Hydroxy-3-Keto-Δ4-Steroids

    Symposium 2 Pathways of Synthesis and Metabolism of Hormonal Steroids

    Some Aspects of Steroid Dynamics

    Discussion. Ring A and Side-chain Reduction Processes in Cortisol Metabolism

    Interaction of Thyroid with Steroid Hormone Metabolism

    Discussion. Thyroid and Steroid Hormone Metabolism

    The Metabolism and Localization in Tissues of Tritium-Labeled Steroid Sex Hormones

    Discussion. Comments on the Biological and Biochemical Aspects of the Experiments

    In Vitro Conversion of Deoxycorticosterone to Some Acidic Metabolites

    Discussion. In Vitro Conversion of Deoxycorticosterone to Some Acidic Metabolites

    Symposium 3 Control of Synthesis and Release of Steroid Hormones

    Neurohumoral Factors from the Brainstem and Epiphysis


    Interrelationship of Renal and Adrenal Hormones

    Discussion. Interrelationship of Renal and Adrenal Hormones

    Hypothalamic Control of the Production of Corticosterone

    Discussion. Effect of Hypothalamic Lesions

    The Regulation of ACTH and Corticosteroid Secretion


    The Inhibiting Action of Adrenocortical Steroids on ACTH Secretion

    Discussion. Neurosecretion and Control of the Pituitary Gland

    Adrenal Cortical Function in Dogs with Central Nervous System Ablations

    Discussion. Hypothalamus and Release of Ovulating Hormone

    Neural Aspects of the Feedback Action of Ovarian Steroids

    Discussion. Neural Aspects of the Feedback Action of Ovarian Steroids: The Role of Progesterone

    Electrolytic Irritative Lesions in the Hypothalamus and Other Forebrain Areas: Effects on Luteinizing Hormone Release and the Ovarian Cycle


    Regulation of Luteinizing Hormone (LH) Secretion by a Hypothalamic LH-Releasing Factor

    Discussion. Control of Ovulating Hormone Release

    Synthesis and Release of Progestin by Rabbit Ovary in Vivo

    Effects of Hypothalamic Deconnection of the Pituitary Control of Testosterone Secretion

    Discussion. Effects of Pituitary Transplantation in Birds

    Symposium 4 Mechanism of Steroid Action

    The Role of Molecular Configuration in the Interaction of Steroid Hormones with Coenzymes and Enzymes


    Steroid Metabolism and Steroid Action

    Discussion. Adrenal Steroids and Adipose Tissue

    Steroids, Nonsteroids, Intermediary Metabolism, Inflammation and their Probable Interrelationships

    Discussion. Aspects of the Anti-inflammatory Action of Prednisolone

    Possible Mode of Action of Adrenocortical Steroids

    Discussion. Glucocorticoids and Alanine α-Ketoglutarate-Transaminase Activity

    The Mode of Action of Cortisol upon Lymphocytes

    On Mechanism of Steroid Action at the Molecular Level

    Symposium 5 Substances Which Affect Synthesis and Action of Steroid Hormones

    Nonhormonal Inhibitors of Adrenocortical Steroid Biosynthesis

    Discussion. Nonhormonal Inhibitors of Adrenocortical Steroid Biosynthesis: Clinical Applications

    Studies on Adrenocortical Inhibitors


    Incretory Modifications Induced by Administration of an Inhibitor of 11β-Hydroxylase (Su-4885) in Different Functional Conditions of the Diencephalic-Hypophyseal-Adrenal System

    The Effects of Treatment with 19-Norsteroids on the Secretion and Metabolism of Cortisol and of Aldosterone in Women

    Discussion. Interaction of Steroid Hormones

    Action of Antialdosterone Compounds in the Laboratory

    Discussion. Aldosterone Antagonism and Aldosterone Inhibition

    The Actions of Steroid Hormones on Estradiol-17β in Uterine Growth and Enzymorphology

    Symposium 6 Nonhormonal Activities of Steroids

    Steroids that Act on the Nervous System

    Discussion. Specificity of Steroid Action

    Direct and Indirect Effects of Deoxycorticosterone (DOC) on Skeletal Muscle Electrolyte and Acid-Base Metabolism

    Discussion. Effects of Anti-inflammatory Steroids on Electrolite Metabolism

    The Effect of Estrogens, Androgens, and Corticoids on Skeletal Dynamics in Man

    Discussion. Evaluation of the Strontium Tracer Technique in the Study of Skeletal Dynamics

    Inotropic Actions of Certain Steroids upon Cardiac Tissue

    Discussion. Actions of Certain Steroids upon Cardiac Tissue

    The Action of Steroids on the Skin

    Discussion. Influence of Steroids on the Melanocytes of the Skin

    Hormonal Factors in Aging

    Discussion. Action of Estrogens on the Skin

    Influence of Steroids on Enzymatic Activities and Permeability of Cells, Mitochondria, and Lysosomes

    Subject Index

Product details

  • No. of pages: 608
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9780323144650

About the Editor

L Martini

Ratings and Reviews

Write a review

There are currently no reviews for "Hormonal Steroids Biochemistry, Pharmacology, and Therapeutics"