Hormonal Proteins and Peptides - 1st Edition - ISBN: 9780124472013, 9781483257969

Hormonal Proteins and Peptides

1st Edition

Editors: Choh Hao Li
eBook ISBN: 9781483257969
Imprint: Academic Press
Published Date: 28th August 1973
Page Count: 284
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Description

Hormonal Proteins and Peptides, Volume I reviews extensively the knowledge on the biology and chemistry of the protein and peptide hormones. This book presents the structures of the various protein and peptide hormones.

Organized into five chapters, this volume begins with an overview of the chemistry of several hormonal glycoproteins. This text then presents the research on the purification and chemistry of thyroid-stimulating hormone (TSH). Other chapters consider the study of ovine interstitial cell-stimulating hormone, and concentrate to some extent on the very closely related bovine species. This book discusses as well some aspects of the biology of the pituitary interstitial cell-stimulating hormone or luteinizing hormone in mammalian species. The final chapter deals with the correlation of the primary structure with function for a better understanding of the mechanism of action of the hormone at a molecular level.

This book is a valuable resource for biologists, biochemists, and research workers.

Table of Contents


List of Contributors

Preface

Contents of Volume II

1. The Chemistry of Glycoproteins

Text

References

2. The Chemistry of Pituitary Thyrotropin

I. Introduction

II. Preparation of Bovine TSH

III. Purification of Human TSH

IV. The Subunits of Bovine TSH and Their Linear Amino Acid Sequences

V. The Carbohydrate Portion of Bovine TSH

VI. A Comparison of the Molecular Parameters of Bovine TSH Determined Directly and as Deduced from the Sequence

VII. The Chemical and Biological Relationships Between TSH, LH, and HCG (Human Chorionic Gonadotropin)

VIII. Comparative Studies—Human TSH

IX. Problems and Possibilities

References

3. The Chemistry of the Interstitial Cell-Stimulating Hormone of Ovine Pituitary Origin

I. Introduction

II. Purification of Ovine ICSH

III. Physical Properties of Ovine ICSH

IV. Chemical Properties of Ovine ICSH

V. The Subunit Nature of ICSH

VI. Structural Studies on the ICSH Subunits

VII. Comments on the Heterogeneity of ICSH

VIII. Concluding Remarks

References

4. The Biology of Pituitary Interstitial Cell-Stimulating Hormone

I. Introduction

II. Gonadotropic Factors of the Pituitary Gland

III. Biological Effects of ICSH in the Female

IV. Role of ICSH in Pregnancy

V. Formation and Maintenance of Corpus Luteum

VI. Biological Effects of ICSH in the Male

VII. Extragonadal Actions of ICSH

VIII. Regulation of ICSH Secretion

IX. Metabolism of ICSH

X. Effects of ICSH on Gonadal Metabolism

XI. Concluding Remarks

References

5. Chemistry of Human Chorionic Gonadotropin

I. General

II. Methods of Purification of HCG

III. Physicochemical Properties

IV. Chemical Composition

V. Amino and Carboxy Terminal Analyses

VI. Quaternary Structure of HCG

VII. Investigation of the Carbohydrate Units in HCG

VIII. Amino Acid Sequence of HCG

IX. General Considerations

References

6. Chemistry and Biosynthesis of Thyroid Iodoproteins

I. Introduction: Definitions and Classifications

II. Chemistry of Thyroid Iodoproteins

III. Biosynthesis of Thyroid Iodoproteins

References

Author Index

Subject Index


Details

No. of pages:
284
Language:
English
Copyright:
© Academic Press 1973
Published:
Imprint:
Academic Press
eBook ISBN:
9781483257969

About the Editor

Choh Hao Li