The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines. The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia.

Key Features

@introbul:Key Features @bul:* Detailed insights into viral packaging, expression, and assembly * Mechanistic understanding of how HIV interacts with receptors and infects cells * Delineation of virally encoded regulatory processes unique to HIV * Clinical Applications: @subbul:* An updated review of current chemotherapeutics for HIV * New concepts in the discovery and design of novel anti-HIV drugs * The latest developments in HIV-vaccine research


Graduate students, postdoctoral fellows, and senior researchers in virology and pharmacology, as well as clinicians and clinical fellows in infectious diseases.

Table of Contents

HIV RNA Packaging and Lentivirus-Based Vectors, A.M.L. Lever. Multiple Biological Roles Associated with the Repeat (R) Region of the HIV-1 RNA Genome, B. Berkhout. HIV Accessory Proteins: Multifunctional Components of a Complex System, S. Bour and K. Strebel. Role of Chromatin in HIV-1 Transcriptional Regulation, C. Van Lint. NF-kB and HIV: Linking Viral and Immune Activation, A.B. Rabson and H.-C. Lin. Tat as a Transcriptional Activator and a Potential Therapeutic Target for HIV-1, A. Gatignol and K.-T. Jeang. From the Outside In: Extracellular Activities of HIV Tat, D. Noonan and A. Albini. Rev Protein and Its Cellular Partners, J. Kjems and P. Askjaer. HIV-1 Nef: A Critical Factor in Viral-Induced Pathogenesis, A.L. Greenway, G. Holloway, and D.A. McPhee. Nucleocapsid Protein of Human Immunodeficiency Virus as a Model Protein with Chaperoning Functions and as a Target for Antiviral Drugs, J.-L. Darlix, G. Cristofari, M. Rau, C. Pechoux, L. Berthoux, and B. Roques. Bioactive CD4 Ligands as Pre- and/or Postbinding Inhibitors of HIV-1, L. Briant and C. Devaux.


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© 2000
Academic Press
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@from:Praise for the Serial @qu:"Recommended not only to pharmacologists but also to all those in related disciplines." @source:--NATURE @qu:"Superb reading material." @source:--JOURNAL OF PHARMACEUTICAL SCIENCES @qu:"The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated." @source:--H.E. Kaufmann in CHEMOTHERAPY