The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines. The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia.
@introbul:Key Features @bul:* Detailed insights into viral packaging, expression, and assembly
- Mechanistic understanding of how HIV interacts with receptors and infects cells
- Delineation of virally encoded regulatory processes unique to HIV
- Clinical Applications: @subbul:* An updated review of current chemotherapeutics for HIV
- New concepts in the discovery and design of novel anti-HIV drugs
- The latest developments in HIV-vaccine research
Graduate students, postdoctoral fellows, and senior researchers in virology and pharmacology, as well as clinicians and clinical fellows in infectious diseases.
HIV Therapeutics: Past, Present, and Future, O. Abu-Ata, J. Slim, G. Perez, and S.M. Smith. HIV Drug Resistance and Viral Fitness, F. Clavel and F. Mammano. Inhibitors of HIV-1 Reverse Transcriptase, M.A. Parniak and N. Sluis-Cremer. HIV-I Protease: Maturation, Enzyme Specificity, and Drug Resistance, J.M. Louis, I.T. Weber, J. Tözsér, G.M. Clore, and A.M. Gronenborn. HIV-I Integrase Inhibitors: Past, Present, and Future, N. Neamati, C. Marchand, and Y. Pommier. Selection of HIV Replication Inhibitors: Chemistry and Biology, S. Hwang, N. Tamilarasu, and T.M. Rana. Therapies Directed against the Rev Axis of HIV Autoregulation, A.I. Dayton and M.J. Zhang. HIV-I Gene Therapy: Promise for the Future, R. Dornburg and R.J. Pomerantz. Assessment of HIV Vaccine Development: Past, Present, and Future, M.W. Cho. HIV-I-Associated Central Nervous System Dysfunction, F.C. Krebs, H. Ross, J. McAllister, and B. Wigdahl. Molecular Mechanisms of Human Immunodeficiency Virus Type I Mother-Infact Transmission, N. Ahmad. Molecular Epidemiology of HIV-I: An Example of Asia, M.-Y. Chen and C.-N. Lee. Simian Immunodeficiency Virus Infection of Monkeys as a Model System for the Study of AIDS Pathogenesis, Treatment and Prevention, V.M. Hirsch and J.D. Lifson. Animal Models for AIDS Pathogenesis, J.J. Trimble, J.R. Salkowitz, and H.W. Kestler. Index. Contents of Previous Volumes.
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- © Academic Press 2001
- 14th September 2000
- Academic Press
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@from:Praise for the Serial @qu:"Recommended not only to pharmacologists but also to all those in related disciplines." @source:--NATURE @qu:"Superb reading material." @source:--JOURNAL OF PHARMACEUTICAL SCIENCES @qu:"The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated." @source:--H.E. Kaufmann in CHEMOTHERAPY