HIV I: Molecular Biology and Pathogenesis: Clinical Applications

HIV I: Molecular Biology and Pathogenesis: Clinical Applications

2nd Edition - December 14, 2007

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  • Editors: J. August, Ferid Murad
  • Hardcover ISBN: 9780123736017

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Although it is one of the most-widely studied viruses, many mysteries still remain about HIV. Covering the latest advances and challenges associated with clinical application of new antiviral drugs and vaccines, this revised edition is a companion to Murad: HIV-1: Molecular Biology and Pathogenesis, Second Edition. Leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus.

Key Features

  • The latest developments in HIV-vaccine research
  • New concepts in the discovery and design of novel anti-HIV drugs


Graduate students, postdoctoral fellows, and senior researchers in virology and pharmacology, as well as clinicians and clinical fellows in infectious diseases

Table of Contents

  • HIV Therapeutics: Past, Present, and Future
    HIV Drug Resistance and Viral Fitness
    Inhibitors of HIV-1 Reverse Transcriptase
    HIV-I Protease: Maturation, Enzyme Specificity, and Drug Resistance
    HIV-I Integrase Inhibitors: Past, Present, and Future
    Selection of HIV Replication Inhibitors: Chemistry and Biology
    Maturation or assembly inhibitor compounds against HIV-1
    HIV-I Gene Therapy: Promise for the Future
    Assessment of HIV Vaccine Development: Past, Present, and Future
    CTL immunity approaches for HIV-1 vaccines
    humoral immunity approaches for HIV-1 vaccines.
    HIV-I-Associated Central Nervous System Dysfunction
    Molecular Mechanisms of Human Immunodeficiency Virus Type I Mother-Infact Transmission
    Molecular Epidemiology of HIV-I: An Example of Asia
    Simian Immunodeficiency Virus Infection of Monkeys as a Model System for the Study of AIDS Pathogenesis, Treatment and Prevention
    Animal Models for AIDS Pathogenesis
    SCID-hu mouse models for studying HIV-AIDS and for drug testing.

Product details

  • No. of pages: 638
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: December 14, 2007
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123736017

About the Serial Editors

J. August

Affiliations and Expertise

John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.

Ferid Murad

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.

Affiliations and Expertise

University of Texas Medical School, Houston, U.S.A.

About the Serial Volume Editor

Kuan-Teh Jeang

Affiliations and Expertise

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.

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