HIV-1: Molecular Biology and Pathogenesis: Viral Mechanisms, Volume 55

2nd Edition

Serial Volume Editors: Kuan-Teh Jeang J. August Ferid Murad
Hardcover ISBN: 9780123736109
eBook ISBN: 9780080548326
Imprint: Academic Press
Published Date: 13th June 2007
Page Count: 488
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Table of Contents

    <li>Dedication</li> <li>Contributors to Volume 55</li> <li>Preface</li> <li>HIV-1 RNA Packaging<ul><li>Publisher Summary</li><li>I Chapter Overview</li><li>II Introduction</li><li>III The Packaging Pathway</li><li>IV RNA/Protein Recognition for Encapsidation: Molecular and Structural Biology</li><li>V Conclusions</li></ul></li> <li>Structure and Function of the HIV Envelope Glycoprotein as Entry Mediator, Vaccine Immunogen, and Target for Inhibitors<ul><li>Publisher Summary</li><li>I Chapter Overview</li><li>II Introduction</li><li>III Structure of the Env (gp120&#x2013;gp41)</li><li>IV Env Interactions with CD4 and Coreceptor (CCR5 or CXCR4) Leading to Membrane Fusion</li><li>V Env Interactions with Antibodies</li><li>VI The Env as Vaccine Immunogen and Target for Inhibitors</li><li>VII Conclusions</li><li>Acknowledgments</li></ul></li> <li>HIV-1 Reverse Transcription: Close Encounters Between the Viral Genome and a Cellular tRNA<ul><li>Publisher Summary</li><li>I Chapter Overview</li><li>II Introduction</li><li>III Reverse Transcription</li><li>IV Specificity of tRNA Primer Usage</li><li>V Identification of the PAS Motif</li><li>VI Proposed Mechanism of Primer Activation</li><li>VII HIV-1 Replication with a Nonself tRNA Primer Confirms the Importance of the PAS Motif</li><li>VIII Conclusions</li><li>Acknowledgments</li></ul></li> <li>Transcription of HIV: Tat and Cellular Chromatin<ul><li>Publisher Summary</li><li>I Chapter Overview</li><li>II Introduction</li><li>III Integrated HIV-1 LTR and Cellular Chromatin</li><li>IV The HIV-1 Tat Protein and Its Modifications</li><li>V Tat-Mediated Transactivation</li><li>V Conclusions</li><li>Acknowledgments</li></ul></li> <li>Posttranscriptional Control of HIV-1 and Other Retroviruses and Its Practical Applications<ul><li>Publisher Summary</li><li>I Chapter Overview</li><li>II Introduction</li><li>III HIV-1 Regulation of Gene Expression</li><li>IV Rev and Its Export Rece


This volume covers the latest advances in the mechanisms of pathogenesis of the HIV-1 virus on target cells. Its companion volume, Advances in Pharmacology 56, shows how new developments in understanding the virus translate to the clinical setting.


Pharmacologists, Molecular biologists, Virologists, Immunologists


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© Academic Press 2007
Academic Press
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About the Serial Volume Editors

Kuan-Teh Jeang Serial Volume Editor

Affiliations and Expertise

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.

J. August Serial Volume Editor

Affiliations and Expertise

John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.

Ferid Murad Serial Volume Editor

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.

Affiliations and Expertise

University of Texas Medical School, Houston, U.S.A.