History of Immunotoxicology

History of Immunotoxicology

1st Edition - April 1, 2019

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  • Author: Jacques Descotes
  • Paperback ISBN: 9780128096796

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History of Immunotoxicology offers the first book-length exploration of the development and importance of the field of immunotoxicology, describing the adverse health effects involving the immune system, hypersensitivity and autoimmunity. It explores new avenues of research and immunotoxicity evaluation, regulatory aspects of immunotoxicology, and the withdrawal/banning from the market of several approved drugs and chemicals due to their immunotoxic effects. In addition, clinical manifestations of immunotoxicity, such as anaphylaxis, opportunistic infections, lymphomas, cytokine storm, and immunotherapy are addressed. Finally, the book considers how the recent past can provide insights on the future practice of immunotoxicology. As preventive measures are implemented to reduce risks, including banning of chemicals or applications of one given chemical, current toxicologists may not be aware of the toxicity potential of chemicals. This book will be of interest to students and researchers in government, industry and academia who have an interest in immunotoxicology.

Key Features

  • Examines the development of immunotoxicology
  • Provides context to current debates on the actual toxicity potential of chemicals
  • Covers major developments and areas of immunotoxicology


Students and researchers in toxicology and pharmaceutical science across government, industry, and academia who have an interest in immunotoxicology. Immunologists, medical doctors, and those interested in scientific history and achievement

Table of Contents

  • 1. The prehistory of immunotoxicology
    2. Focus on autoimmunity and hypersensitivity
    3. Clinical immunotoxic effects
    4. Drug withdrawals caused by inacceptable immunotoxicity
    5. Pioneering inter-laboratory studies
    6. Regulatory aspects of immunotoxicology
    7. Immunotherapy of poisonings
    8. Insights on the future of immunotoxicity evaluation

Product details

  • No. of pages: 125
  • Language: English
  • Copyright: © Academic Press 2025
  • Published: April 1, 2019
  • Imprint: Academic Press
  • Paperback ISBN: 9780128096796

About the Author

Jacques Descotes

Professor Descotes has written numerous books including the 2004 Elsevier publication Principles and Methods of Immunotoxicology (LOE $44,356; 9780444510938) and published over 450 journal articles as well as working on many journal editorial boards including: • Biomedical and Environmental Sciences (Academic Press), Editorial Board • Environmental Toxicology (John Wiley & sons), Editorial Board • Journal of Applied Toxicology (John Wiley & sons), Editorial Board • Toxicology (Elsevier), Editorial Board • International Immunopharmacology (Elsevier), Editorial Board • Open Journal of Immunology (Bentham), Editorial Board • Open Journal of Toxicology (Bentham), Editor in chief • Journal of Biomedicine and Biotechnology (Hindawi), Editorial Board • Therapeutic Advances in Drug Safety (Sage Journals), Editorial Board

Affiliations and Expertise

Pharmacovigilance Unit, Lyon Poison Center, Lyon, France

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