Histophysiology of Synapses and Neurosecretion

Histophysiology of Synapses and Neurosecretion

International Series of Monographs on Pure and Applied Biology: Modern Trends in Physiological Sciences

1st Edition - January 1, 1964

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  • Author: Eduardo D.P. De Robertis
  • eBook ISBN: 9781483180595

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Histopbysiology of Synapses and Neurosecretion discusses the relationship between subcellular structure and function in synapses. The title discusses how neurosecretion phenomenon takes place in the important areas of central and peripheral nervous system. The first part of text deals with the synapse. Topics such as the concept of synaptic transmission, morphology of synaptic region, and ultrastructure of synaptic region are covered in the first part. Part I also discusses the MORPHO-physiological correlations in certain synapses; and neurochemical studies in isolated nerve endings and synaptic vesicles of the CNS. The second part of the selection covers neorosecretion. Part II tackles the neurohumoral mechanisms and secretion in the hypothalamicneurohypophysial system; secretory processes; and secretion in adrenergic nerves and endings. The book will be of great use to student, researchers, and practitioners of neurology.

Table of Contents

  • Introduction

    Part I The Synapse

    1 General Concepts on Synaptic Transmission

    Morphological Concept of the Synapse

    Physiological Concept of the Synapse

    Mechanisms of Synaptic Transmission

    Microphysiological Studies of Synaptic Transmission


    2 Morphology of the Synaptic Region

    Distribution of Synapses: Specific Synaptic Patterns

    Number and Size of Endings

    Structure of Synaptic Endings


    3 General Ultrastructure of the Synaptic Region

    Preliminary Observations of Synaptic Regions with the Electron Microscope

    General Description of the Synaptic Region


    4 Ultrastructure of Special Synapses and the Problem of Localization of Synaptic Vesicles

    Ultrastructure of the Neuromuscular Junction

    Synapses in Peripheral Ganglia

    Synapses in the Electric Organ

    Invertebrate Synapses

    Microvesicles in Receptor Endings

    Microvesicles in Regenerating Nerves

    The Problem of the Localization of Synaptic Vesicles

    The Role of Acetylcholine at Pre- and Postsynaptic Sites

    Ultrastructure of Electrical Synapses


    5 Morpho-physiological Correlations in Certain Synapses

    Changes in Nerve Endings of the Adrenal Medulla after Electrical Stimulation

    Origin of Synaptic Vesicles

    Stimulation of the Neuromuscular Junction

    Mobilization of Synaptic Vesicles

    Changes in Synaptic Structure With Environmental Temperature

    The Synaptic Vesicles as Units of Transmitter Substances

    The Action of Botulin Toxin on Synaptic Transmission

    Physiology and Geometry of the Synapse

    The So-Called Synaptic Barrier


    6 Synaptic Vesicles and the Functional Changes of Synapses During Nerve Degeneration

    Submicroscopic Morphology of Degenerating Synapses

    Submicroscopic Morphology and Function in Degenerating Myoneuronal Junctions


    7 Synapses of the Retina

    Submicroscopic Morphology of Rod and Cone Synapses

    Submicroscopic Morphology and Function of Inner Synapses of the Retina


    8 Neurochemical Studies in Isolated Nerve Endings and Synaptic Vesicles of the CNS

    Acetylcholine and Cholineacetylase Containing Particles of the Brain

    Acetylcholinesterase in the Nervous Tissue

    Isolation of Synaptic Vesicles

    Isolation of Nerve Endings Containing the ACh-System

    Localization of the ACh-System Within the Synaptic Complex

    Further Studies on the Isolation of Nerve Endings

    Subcellular Localization of AChE and Synaptic Function

    Release of Acetylcholine from Isolated Nerve Endings

    The Physiological Release of ACh

    Subcellular Distribution of 5-Hydroxytryptamine and 5-Hydroxytryptamine Decarboxylase in the CNS

    Subcellular Distribution of Noradrenaline (NA) in the CNS

    Subcellular Distribution of Monoaminooxidase (MAO) in the CNS

    Subcellular Distribution of Enzymes related to γ-Aminobutyric Acid (GABA)


    Part II Neurosecretion

    9 Neurohumoral Mechanisms and Secretion in the Hypothalamic-Neurohypophysial System

    Unitary Concept of Neurohumoral Mechanisms

    The Hypotbalamic-Neurohypophysial System

    Neurosecretion in Synaptic Areas of Annelids and Molluscs


    10 Secretory Process of the Adrenal Medulla

    Cell Types in the Adrenal Medulla

    Submicroscopic Morphology of the Adrenomedullarv Cells

    Formation of the Secretion Droplets

    Nature of the Secretion Droplets

    Release of the Secretion Droplets


    11 Secretory Process in the Nerve Endings of the Pineal Gland

    Structure and Innervation of the Pineal Gland

    Submicroscopic Morphology of the Pinealocyte

    Adrenergic Nerve Fibers and Endings of the Pineal Gland

    Plurivesicular Material of the Pineal Nerve Endings


    12 Secretion in Adrenergic Nerves and Endings

    Structural Organization of Neuroerffectors

    The Plurivesicular Component of Adrenergic Axons and Endings

    Biosynthesis, Storage and Release of the Transmitter in Adrenergic Nerves

    Adrenergic Axons and Endings in the Hypothalamus




Product details

  • No. of pages: 258
  • Language: English
  • Copyright: © Pergamon 1964
  • Published: January 1, 1964
  • Imprint: Pergamon
  • eBook ISBN: 9781483180595

About the Author

Eduardo D.P. De Robertis

Affiliations and Expertise

Institute of General Anatomy and Embryology, University of Buenos Aires, Buenos Aires (Argentina)

About the Editors

P. Alexander

Z. M. Bacq

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