Histopathology of Preclinical Toxicity Studies

Histopathology of Preclinical Toxicity Studies

Interpretation and Relevance in Drug Safety Evaluation

4th Edition - October 7, 2011

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  • Author: Peter Greaves
  • eBook ISBN: 9780444538611
  • Hardcover ISBN: 9780444538567

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Description

The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings.

Key Features

  • This edition is in full color and features nearly 200 high-quality images
  • Provides extended commentary on the relevance of pathological findings and features a fully updated bibliography containing sources for further reading
  • Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions

Readership

Clinical toxicologists, pathologists, and pharmacologists involved professionally in drug safety evaluation and especially those researchers working in pharmaceutical companies, contract laboratories and in government agencies

Table of Contents

  • Chapter 1. Introduction

    References

    Chapter 2. Integumentary System

    Skin and subcutaneous tissue

    References

    Chapter 3. Mammary Gland

    References

    Chapter 4. Hemopoietic and Lymphatic Systems

    Blood and bone marrow

    Lymphoid system

    Lymph nodes

    Spleen

    Thymus

    Lymphoreticular neoplasms

    References

    Chapter 5. Musculoskeletal System

    Bone

    Joints

    Skeletal muscle

    References

    Chapter 6. Respiratory Tract

    Nose, nasal sinuses, nasopharynx and pharynx

    Larynx and trachea

    Bronchi and lungs

    References

    Chapter 7. Cardiovascular System

    Heart and pericardium

    Systemic blood vessels

    Pulmonary blood vessels

    References

    Chapter 8. Digestive System

    Mouth and oropharynx

    Salivary glands

    Esophagus

    Forestomach

    Stomach (glandular)

    Small intestine

    Large intestine

    References

    Chapter 9. Liver and Pancreas

    Liver

    Bile ducts, biliary system

    Gallbladder

    Exocrine pancreas

    Endocrine Pancreas

    References

    Chapter 10. Urinary Tract

    Kidney

    Urinary bladder

    Neoplasia

    References

    Chapter 11. Male Genital Tract

    Prostate gland

    Preputial (and clitoral) glands

    Epididymis

    Testis

    References

    Chapter 12. Female Genital Tract

    Clitoral glands

    Vagina

    Cervix

    Uterus

    Ovary

    References

    Chapter 13. Endocrine Glands

    Pituitary gland

    Adrenal gland

    Thyroid gland

    Parathyroid gland

    References

    Chapter 14. Nervous System and Special Sense Organs

    Brain

    Spinal cord, spinal nerve roots and peripheral nerves

    Eye

    Ear

    References

    Index

Product details

  • No. of pages: 892
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: October 7, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780444538611
  • Hardcover ISBN: 9780444538567

About the Author

Peter Greaves

Peter Greaves
MBChB, FRCPath, Consulting Pathologist and Honorary Senior Lecturer, Department of Cancer Studies and Molecular Medicine, University of Leicester, UK

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