Histone Deacetylase Inhibitors as Cancer Therapeutics, Volume 116

1st Edition

Serial Volume Editors: Steven Grant
Hardcover ISBN: 9780123943873
eBook ISBN: 9780123946089
Imprint: Academic Press
Published Date: 1st November 2012
Page Count: 288
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Table of Contents



Chapter One. Histone Deacetylase Inhibitors Disrupt the Mitotic Spindle Assembly Checkpoint By Targeting Histone and Nonhistone Proteins


1. Introduction

2. HDACi Dysregulate Cell Cycle Progression

3. HDACi Disrupt Normal Mitosis

4. Mechanism of HDACi-Induced Aberrant Mitosis

5. Conclusions


Chapter Two. Mechanisms of Resistance to Histone Deacetylase Inhibitors

1. Introduction

2. Mechanisms of Resistance to HDAC Inhibitors

3. Clinical Trials of HDAC Inhibitors

4. Conclusion


Chapter Three. HDAC Inhibitors: Roles of DNA Damage and Repair

1. Introduction

2. HDACis and DNA Damage

3. HDACis and Oxidative Stress

4. SIRTs: DNA Damage and Oxidative Stress Responses

5. Concluding Remarks and Future Directions


Chapter Four. HDAC Inhibitor Modulation of Proteotoxicity as a Therapeutic Approach in Cancer

1. Background: The Cellular Response to Proteotoxicity

2. Proteotoxicity as a Therapeutic Target in Cancer

3. Summary and Future Directions


Chapter Five. Intrinsic and Extrinsic Apoptotic Pathway Signaling as Determinants of Histone Deacetylase Inhibitor Antitumor Activity

1. Introduction

2. The Intrinsic Apoptosis Pathway

3. HDACi Induce Apoptosis Via the Intrinsic Apoptosis Pathway

4. The Effects of HDACi on Antiapoptotic Bcl-2 Family Genes

5. Effects of HDACi on Proapoptotic BCL-2 Family Members

6. Effects of HDACi on Bid

7. Effects of HDACi on Bim

8. Effects of HDACi on Bmf

9. Effects of HDACi on Bad

10. Effects of HDACi on Noxa/Puma

11. Effects of HDACi on Bax and/or Bak

12. The Extrinsic Apoptosis Pathway

13. Effects of HDACi on the Extrinsic Apoptosis Pathway



Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics."

Key Features

  • Provides invaluable information on the exciting and fast-moving field of cancer research
  • This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics"
  • Outstanding and original reviews


Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.


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© Academic Press 2012
Academic Press
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About the Serial Volume Editors

Steven Grant Serial Volume Editor