Histone Deacetylase Inhibitors as Cancer Therapeutics - 1st Edition - ISBN: 9780123943873, 9780123946089

Histone Deacetylase Inhibitors as Cancer Therapeutics, Volume 116

1st Edition

Serial Volume Editors: Steven Grant
eBook ISBN: 9780123946089
Hardcover ISBN: 9780123943873
Imprint: Academic Press
Published Date: 1st November 2012
Page Count: 288
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Table of Contents

Contributors

Preface

Chapter One. Histone Deacetylase Inhibitors Disrupt the Mitotic Spindle Assembly Checkpoint By Targeting Histone and Nonhistone Proteins

Abbreviations

1. Introduction

2. HDACi Dysregulate Cell Cycle Progression

3. HDACi Disrupt Normal Mitosis

4. Mechanism of HDACi-Induced Aberrant Mitosis

5. Conclusions

References

Chapter Two. Mechanisms of Resistance to Histone Deacetylase Inhibitors

1. Introduction

2. Mechanisms of Resistance to HDAC Inhibitors

3. Clinical Trials of HDAC Inhibitors

4. Conclusion

References

Chapter Three. HDAC Inhibitors: Roles of DNA Damage and Repair

1. Introduction

2. HDACis and DNA Damage

3. HDACis and Oxidative Stress

4. SIRTs: DNA Damage and Oxidative Stress Responses

5. Concluding Remarks and Future Directions

References

Chapter Four. HDAC Inhibitor Modulation of Proteotoxicity as a Therapeutic Approach in Cancer

1. Background: The Cellular Response to Proteotoxicity

2. Proteotoxicity as a Therapeutic Target in Cancer

3. Summary and Future Directions

References

Chapter Five. Intrinsic and Extrinsic Apoptotic Pathway Signaling as Determinants of Histone Deacetylase Inhibitor Antitumor Activity

1. Introduction

2. The Intrinsic Apoptosis Pathway

3. HDACi Induce Apoptosis Via the Intrinsic Apoptosis Pathway

4. The Effects of HDACi on Antiapoptotic Bcl-2 Family Genes

5. Effects of HDACi on Proapoptotic BCL-2 Family Members

6. Effects of HDACi on Bid

7. Effects of HDACi on Bim

8. Effects of HDACi on Bmf

9. Effects of HDACi on Bad

10. Effects of HDACi on Noxa/Puma

11. Effects of HDACi on Bax and/or Bak

12. The Extrinsic Apoptosis Pathway

13. Effects of HDACi on the Extrinsic Apoptosis Pathway

14. Effects of HDACi on DR and Their Ligands

15. Concluding Remarks

References

Chapter Six. Histone Deacetylase Inhibitors and Rational Combination Therapies

Abbreviations

1. Introduction

2. Histone Deacetylases

3. Histone Deacetylase Inhibitors

4. Determinants of HDAC Inhibitor Lethality

5. HDACI Strategies in Cancer Therapy

6. Summary and Future Directions

References

Chapter Seven. HDAC Inhibitors and Chaperone Function

1. Introduction

2. HDAC Inhibitors

3. Chaperones and Protein Homeostasis

4. Regulation of Hsp90 Chaperone Function by Reversible Acetylation

5. HDAC3 is the Nuclear Hsp90 Deacetylase

6. HDAC Inhibitor-Mediated Regulation of Hsp70

7. HDAC Regulation of Hsp40

8. Regulation of GRP78 Function by HDAC6

9. Concluding Remarks

References

Index


Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics."

Key Features

  • Provides invaluable information on the exciting and fast-moving field of cancer research
  • This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics"
  • Outstanding and original reviews

Readership

Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.


Details

No. of pages:
288
Language:
English
Copyright:
© Academic Press 2012
Published:
Imprint:
Academic Press
eBook ISBN:
9780123946089
Hardcover ISBN:
9780123943873

Ratings and Reviews


About the Serial Volume Editors

Steven Grant Serial Volume Editor