Histidine Kinases in Signal Transduction

1st Edition

Authors: Masayori Inouye Rinku Dutta
Hardcover ISBN: 9780123724847
eBook ISBN: 9780080534015
Imprint: Academic Press
Published Date: 12th November 2002
Page Count: 520
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Living cells are constantly sensing environmental changes, and their abilities to sense these changes and adapt to them are essential for their survival. In bacteria, histidine kinases are the major sensors for these environmental stresses, enabling cells to adapt to new growth conditions.

Written by leading experts in the field, this book provides an up-to-date and comprehensive review on the structure and function of histidine kinases. It also provides extensive information on the physiological roles of histidine kinases in bacteria and eukaryotes.

An an essential reference for cell biologists, microbiologists, molecular biologists, and biochemists interested in signal transduction. Experimental biologists and pharmacologists studying signal transduction systems in living organisms will also find it a valuable research tool.

Key Features

Key Features

  • The first comprehensive book on the roles of histidine kinases in cells
  • 23 in-depth chapters written by leading experts in the field
  • Describes the most recent advances in the field of signal transduction


Biochemists; molecular biologists, experimental biologists; pharmocologists; pharmaceutical companies with R&D programs in broad spectrum antibiotics; and specialists studying signal transduction systems in living organisms.

Table of Contents

Preface Contributors 1 Histidine Kinases: Introductory Remarks Introduction Basic Structure of Histidine Kinases (HKs) Uniqueness of HKs Difference between HKs and Ser/Thr/Tyr Kinases Signal Transduction Mechanism Regulation of Kinase and Phosphatase Activities: Switch Model and Rheostat Model Concluding Remarks References 2 The Histidine Kinase Family: Structures of Essential Building Blocks Introduction Kinase/Phosphatase Core Domain Phosphotransfer Domain Considerations on Domain Interactions Concluding Remarks References 3 Regulation of Porins in Escherichia coli by the Osmosensing Histidine Kinase~hosphatase EnvZ Introduction Domain A Is the Catalytic Domain Domain B Is the Catalysis-Assisting and ATP-Binding Domain Monomeric Histidine Kinase: Topological Arrangement between Domain A and Domain B Role of DNA in EnvZ Function Stoichiometric Complex Formation between EnvZ and OmpR Regulation of Kinase and Phosphatase Activities: Switch Model versus Rheostat Model Mechanism of Osmoregulation Concluding Remarks References 4 Structure and Function of CheA, the Histidine Kinase Central to Bacterial Chemotaxis Introduction Modular Structure of CheA A Superfamily of Histidine Kinases and ATPases Nucleotide Binding by CheA P4 and the GHL ATPases ATP Hydrolysis and Conformation of P4 HPt Domain P1 and Phosphoryl Transfer P2 Domain and Response Regulator Coupling A Separate Dimerization Domain Receptor Coupling by the P5 Regulatory Domain Is Flexibility between Domains Important for Signaling? Controlling Protein-Protein Interactions with ATP Prospects for the Design of Antibiotics Directed at CheA What Is Next? References 5 Transmembrane Signaling and the Regulation of Histidine Kinase Activity Introduction Membrane Receptor Kina


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© Academic Press 2003
Academic Press
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About the Author

Masayori Inouye

Affiliations and Expertise

Robert Johnson Medical School, Picataway, New Jersey, U.S.A.

Rinku Dutta

Affiliations and Expertise

Robert Wood Johnson Medical School, NJ, USA


"...this book contains 23 chapters written by some of the major researchers in the field. ...Of likely utility for biologists, microbiologists, molecular biologists, and biochemists interested in signal transduction, as well as experimental biologists and pharmacologists." —SCITECH BOOK NEWS (March 2003)