Herbal Bioactive-Based Drug Delivery Systems

Challenges and Opportunities

1st Edition - March 13, 2022
Editors: Inderbir Singh Bakshi, Rajni Bala, Reecha Madaan, Rakesh K. Sindhu
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 3 8 5 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 1 0 - 3

Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standa… Read more

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Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations. The book first explores specific drug delivery systems such as gastrointestinal, ocular, pulmonary, transdermal, and vaginal and rectal. It then discusses novel applications for nano, cosmetics, nutraceuticals, wound healing and cancer treatment. Finally, there is a section focusing on standardization and regulation which includes an enhancement of properties. This book is an essential resource for pharmacologists, pharmaceutical scientists, material scientists, botanists, and all those interested in natural products and drug delivery systems developments.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. Role of herbal bioactives and their formulations in the treatment of gastrointestinal disorders
Abstract
1.1 Introduction
1.2 Role of herbal bioactives and formulations in the treatment of gastrointestinal tract disorders
1.3 Conclusion
Acknowledgments
Conflict of interests
Funding
References
Chapter 2. Herbal bioactives for ocular drug delivery systems
Abstract
2.1 Introduction
2.2 Anatomy, physiology, and pharmacokinetic of eye
2.3 Herbal medicine for ocular diseases
2.4 Herbal medicine for ocular drug delivery systems
2.5 Herbal excipients used in ocular drug delivery systems
2.6 Conclusions and future perspectives
References
Chapter 3. Herbal bioactives for pulmonary drug delivery systems
Abstract
3.1 Introduction
3.2 Asthma
3.3 Chronic obstructive pulmonary disease
3.4 Lung cancer
3.5 Pulmonary fibrosis
3.6 Research and market scenario
3.7 Conclusion
References
Chapter 4. Herbal bioactives in transdermal drug delivery system
Abstract
4.1 Introduction
4.2 Herbal bioactives
4.3 Merits and demerits of herbal drug formulations
4.4 Transdermal drug delivery system
4.5 Novel herbal bioactive carriers in transdermal drug delivery
4.6 Proniosomes
4.7 Conclusion
References
Chapter 5. Herbal bioactive–based vaginal and rectal drug delivery systems
Abstract
5.1 Introduction
5.2 Vaginal route for herbal bioactives
5.3 Rectal route for herbal bioactives
5.4 Conclusion and future scope
References
Chapter 6. Herbal bioactive–based nano drug delivery systems
Abstract
6.1 Introduction
6.2 History and conventional approaches to herbal bioactive
6.3 Principle objectives for nano drug delivery system and herbal bioactive
6.4 Recent approaches of drug delivery system for herbal bioactive substances
6.5 Why nano drug delivery for herbal bioactive
6.6 Types of drug delivery system used for herbal bioactive
6.7 Future perspective and challenges of herbal bioactive
Conflict of interest
References
Chapter 7. Herbal bioactive–based cosmetics
Abstract
7.1 Introduction
7.2 Categories of cosmetics
7.3 Challenges/disadvantages of synthetic-based cosmetic
7.4 Herbal bioactive cosmetic products
7.5 Sources of some notable herbal bioactive ingredients and their uses
7.6 Standardization of useful herbal bioactive ingredients in cosmetics
7.7 Patented herbal bioactive-based cosmetics
References
Chapter 8. Herbal bioactive–based nutraceuticals using a metabolomics approach
Abstract
8.1 Introduction
8.2 Nutraceuticals and development in metabolomics
8.3 Metabolomics in herbal plants
8.4 Techniques in metabolomics
8.5 Profiling of bioactives and classifications
8.6 Nutraceuticals biomarkers from metabolomics approaches
8.7 Quality control and optimization
8.8 Conclusion
Acknowledgement
References
Chapter 9. Herbal bioactives for wound healing application
Abstract
9.1 Introduction
9.2 Stages of wound healing
9.3 Nanotechnology based approached for wound healing
9.4 Patents
9.5 Future directions and conclusions
References
Chapter 10. Therapeutic updates and future prospects on anticancer effects of medicinal plants and phytochemicals
Abstract
10.1 Introduction
10.2 Global cancer statistics
10.3 Carcinogenesis and treatment strategies
10.4 Role of phytochemicals in cancer for complementary therapy
10.5 Phytochemicals and molecular mechanisms of action in cancer
10.6 Signal transduction and signaling pathways involved in cancer
10.7 Potentials of medicinal plants and phytochemicals for cancer chemoprevention and therapy
10.8 Phytochemicals and clinical trials for cancer chemotherapeutics
10.9 Future recommendations and conclusions
10.10 Conflict of interest statement
10.11 Financial disclosure
References
Chapter 11. Herbal bioactive-incorporated scaffolds for wound healing applications
Abstract
11.1 Background
11.2 Curcumin-incorporated scaffolds for wound healing applications
11.3 Quercetin-incorporated scaffolds for wound healing applications
11.4 EGCG-incorporated scaffolds for wound healing applications
11.5 Moringa extract incorporated scaffolds for wound healing applications
11.6 Miscellaneous
References
Chapter 12. Development of natural bioactive delivery systems through pressurized fluids-modern techniques
Abstract
12.1 Introduction
12.2 Classification of emergent methods based on pressurized fluid function: solvent, solute, and antisolvent
12.3 Development of delivery systems through emergent methods and their potential application in human health
12.4 Conclusion
Acknowledgment
References
Chapter 13. Nanoformulated herbal bioactives for the treatment of neurodegenerative disorders
Abstract
13.1 Introduction
13.2 Neurodegenerative diseases
13.3 Herbal bioactives in the treatment of neurodegenerative diseases
13.4 Nanoformulated herbal bioactive in neurodegenerative diseases
13.5 Conclusion
References
Chapter 14. Standardization of herbal bioactives
Abstract
14.1 Introduction
14.2 Standardization of herbals
14.3 Analytical methods for herbal standardization
14.4 Some practical aspects of extraction
14.5 Challenges while working with drug delivery system containing bioactive constituents
14.6 Directions for further studies
14.7 Conclusion
Acknowledgment
References
Chapter 15. Enhancement of the properties of herbal bioactives for drug delivery application
Abstract
15.1 Introduction
15.2 Enhancement of the absorption of herbal bioactives
15.3 Therapeutic modifications
15.4 Approaches to improve the stability of herbal bioactives
15.5 Conclusion
References
Chapter 16. Regulatory considerations of herbal bioactive–based formulations
Abstract
16.1 Introduction
16.2 Classification of herbal medicines
16.3 Facts and statistics of herbal medicinal products
16.4 Need for herbal regulations
16.5 Challenges in regulation of herbal medicines
16.6 Indian regulatory body
16.7 United States regulatory body
16.8 European regulatory system
16.9 Legal status and regulatory guidelines of various countries
16.10 Conclusion
16.11 Recommendations
References
Chapter 17. Modern extraction techniques for herbal bioactives
Abstract
17.1 Introduction
17.2 Pulsed electric field–assisted extraction
17.3 Ultrasound-assisted extraction
17.4 Microwave-assisted extraction
17.5 Pressurized liquid extraction
17.6 Supercritical fluid extraction
17.7 Conclusion and future challenges
References
Index

Inderbir Singh Bakshi

Dr. Inderbir Singh Bakshi is gold medalist in M-Pharmacy (Pharmaceutics) from IIT BHU, Varanasi, UP, India and PhD from Punjabi University, Patiala, Punjab, India. Presently he is working as Professor & HOD (Pharmaceutics) at Chitkara College of Pharmacy, Chitkara University, Rajpura, Patiala, Punjab, India. He has total experience of 19 years from both industry and academia. His research interests include NDDS, GRDDS, biopolymers, modified polymers/excipients, QbD. He has published 103 research/review articles in national and international journals, 6 books, 15 book chapters, 2 patents granted and 11 patents (applied) to his credit. He has research collaborations with various scientists of national and international repute. He is member of Indian Pharmacy Graduate Associate (IPGA) and national general secretary of Society of Pharmaceutical Education and Research (SPER), India. He has supervised 43 M-Pharmacy and 7 PhD candidates and organized many conferences/seminars as organizing secretary. He is a visiting Professor and researcher at WITS Advanced Drug Delivery Platform (WADDP) and Department of Pharmacy and Pharmacology, University of Witwatersrand, Johannesburg, South Africa.

Affiliations and expertise

Professor and HOD, Chitkara College of Pharmacy, Chitkara University, Punjab, India

Rajni Bala

Dr. Rajni Bala is M-Pharmacy in Pharmaceutics from University department of Pharmaceutical Sciences, Nagpur University campus, Nagpur, India and PhD from Chitkara University, Rajpura, Punjab, India. Presently she is working as Professor & Deputy Dean Academics (UG Course) at Chitkara College of Pharmacy, Chitkara University, Rajpura, Patiala, Punjab, India. She has total experience of 24 years from academia. Her research interests include NDDS (Liposomes, Phytosomes), fast dissolving drug delivery systems using natural polymers their formulation and optimization. She has published 31 research/review articles in national & international journals of repute and filled Five patents (applied). She has supervised 8 M-Pharmacy and 2 PhD candidates and organized many conferences/seminars as organizing secretary. She is life member of various national Professional bodies like IPGA, SPER and APTI.

Affiliations and expertise

Chitkara College of Pharmacy, Chitkara University, Punjab, India

Reecha Madaan

Prof. Reecha Madaan has done B. Pharm from MDU Rohtak, M. Pharm from Panjab University, Chandigarh, India and PhD from NIMS University, Jaipur, India. She has 19 years of teaching and research experience. Her research area includes exploring Traditional Plants for various pharmacological activities and role of natural polymers, gums and mucilage as pharmaceutical excipients in Drug delivery. One of her research work on isolation of Natural molecules from plant sources is appreciated by Sami Laboratories, Bengaluru. She has guided 5 post graduate Students and 03 PhD (2 pursuing) student. She has published 45 research papers and filed 05 patents. She has authored one book entitled “Text Book on Herbal Drug Technology”. She has delivered many invited talks in different national and international conferences and seminars, and chaired various technical sessions in different national and international conferences. Prof Reecha is representing North West Region being member of Association of Pharmaceutical teachers of India. She is life member of various national societies like IPGA, APTI, SOPI and Society of Pharmacognosy.

Affiliations and expertise

Chitkara College of Pharmacy, Chitkara University, Punjab, India

Rakesh K. Sindhu

Dr. Rakesh K. Sindhu: Associate Professor in Department of Pharmacognosy and Natural Products, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India. He is involved in research regarding standardization, Phytochemi¬cal and Pharmacological Evaluation of herbal drugs/ products. Formulation development and standardization of herbal products He had published more than 50 research papers in reputed journals and presented papers in 8 international and 30 national conferences. He is actively involved in reviewing research papers of well repute journals and member and serving as editorial broad member for national and international journals during 14 years of experience in academics and research. He has filled 9 patents and published 6 book and 10 book chapters. He is the recipient of Bharat Shiksha Ratan from Global Society for Health and Education Research, New Delhi, India for his contribution in academics and research in the field of pharmaceutical sciences and Best Ph. D. Student award in 2015 from Society of Pharmaceutical Education and Research, India. He is life member of Association of Pharmaceutical Teachers of India (APTI), Medicinal Aromatic Plants Association of India (MAPAI) and Society of Pharmaceutical Education Research (SPER).

Affiliations and expertise

Professor and HOD (Pharmaceutics) at Chitkara College of Pharmacy, Chitkara University, Rajpura, Patiala, Punjab, India