Hepatic Fibrosis
Mechanisms and Targets
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Hepatic Fibrosis: Mechanisms and Targets is a complete volume of liver extracellular matrix biology, including molecular signaling pathways, cells and factors that modulate fibrogenesis and fibrosis. The book uses an integrated approach toward the molecular and cellular mechanisms involved in the synthesis and degradation of hepatic fibrotic tissue, emphasizing the possible molecular targets to fight fibrosis. This important reference describes, in detail and didactically, the cellular and molecular events that are conducive to fibrosis that leads to cirrhosis, hepatocellular carcinoma and death. The provided information allows readers to understand the molecular mechanisms of hepatic fibrogenesis to accelerate the development of new therapies.
Key Features
- Presents progression from inflammation to fibrosis, with a special focus on the molecular mechanisms involved
- Didactically explains the participation of cells, cytokines and factors in profibrogenic pathways
- Illuminates the causative participation of free radicals in liver fibrogenesis
- Explains the role of gut dysbiosis in chronic liver diseases leading to fibrosis
- Provides experimental models to study liver fibrosis and describes available, noninvasive monitoring methods
Readership
Basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver diseases, fibrosis, and those interested in molecular biology and mechanisms of diseases. Gastroenterologists, hepatologists, and other physicians. First degree and postgraduate students of medicine and other students in the biological area, molecular biologists, etc. Pharmaceutical companies may find this book useful for the development of new drugs based on the molecular targets described in each chapter
Table of Contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Acknowledgments
- Chapter 1. The healthy and diseased extracellular matrix of the liver
- Introduction
- The extracellular matrix
- Collagens
- The wound healing response
- Metalloproteinases in liver fibrosis
- Conclusions
- Chapter 2. From inflammation to fibrosis
- Introduction
- Cell death and fibrosis
- The inflammasome and fibrosis
- The hedgehog signaling pathway regulates inflammation in liver fibrosis
- Hepatic macrophages and liver diseases
- The role of gut dysbiosis in inflammation and fibrosis
- Gut dysbiosis and liver diseases
- Conclusions
- Chapter 3. Cells, cytokines, and factors involved in profibrogenic pathways
- Introduction
- Mechanisms of hepatic stellate cell activity regulation
- Cytokines and factors involved in profibrogenic pathways
- Differential regulation of Smad pathways in acute and chronic liver damage
- Inflammatory cytokines that promote fibrosis
- Noncoding micro-RNA regulation of liver fibrosis
- Other profibrogenic signaling pathways
- Conclusions
- Chapter 4. Role of free radicals in hepatic fibrogenesis
- Introduction
- Reactive oxygen species induce liver fibrosis
- Role of reactive nitrogen species in liver fibrogenesis
- Hepatic fibrogenesis can be regualted by nuclear factor-related factor-2
- Conclusions
- Chapter 5. Role of gut dysbiosis in chronic liver disease leading to fibrosis
- Introduction
- Dysbiosis is associated with the progression to fibrosis in chronic hepatic injury
- The intestinal epithelium
- Translocation of bacteria in chronic hepatic injury
- Fibrosis and pattern recognition receptors
- Toll-like receptors
- NOD-like receptors in liver fibrosis
- Cirrhosis and the microbiome
- Conclusions
- Chapter 6. Alcohol-induced liver fibrosis
- Introduction
- Alcohol intake and liver disease
- The stages of alcoholic liver disease
- Alcohol-induced fibrosis
- Conclusions
- Chapter 7. From fatty liver to nonalcoholic steatohepatitis with fibrosis
- Introduction
- Fatty liver
- Nonalcoholic steatohepatitis
- Nonalcoholic steatohepatitis and immune cells
- From liver steatosis to nonalcoholic steatohepatitis with fibrosis
- Role of hepatic stellate cell activation in nonalcoholic steatohepatitis-induced fibrosis
- Hepatocyte death may contribute to cell-cell profibrogenic networks
- Molecular pathways that lead to hepatic stellate cell activation and NASH fibrosis
- Metabolic alterations may induce nonalcoholic steatohepatitis fibrosis
- Macrophages and fibrosis in nonalcoholic steatohepatitis
- Beneficial effects of hepatic stellate cells in nonalcoholic steatohepatitis
- Conclusions
- Chapter 8. Chronic viral hepatitis induced liver fibrosis
- Introduction
- Fibrosis induced by chronic hepatitis B
- Fibrosis induced by chronic hepatitis C
- Oxidant stress may induce fibrosis in hepatitis C/hepatitis B virus infection
- Conclusions
- Chapter 9. Fibrosis induced by chronic cholestatic diseases
- Introduction
- Chronic cholestasis leads to fibrogenesis
- The role of bile acids in liver fibrogenesis
- Biliary atresia
- Conclusions
- Chapter 10. Experimental models of hepatic fibrosis
- Introduction
- Alcohol-induced liver disease models
- Animal models of advanced fibrosis and cirrhosis
- Fibrosis induced by dietary models
- Conclusions
- Chapter 11. Monitoring of hepatic fibrosis
- Introduction
- Serological tests
- Imaging tests
- Sequential algorithms
- Emerging technologies
- Markers of collagen turnover
- Conclusion
- Index
Product details
- No. of pages: 274
- Language: English
- Copyright: © Academic Press 2022
- Published: April 23, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323997645
- eBook ISBN: 9780323952897
About the Author
Pablo Muriel
Dr. Muriel PhD has research experience in the pathophysiology and pharmacology of liver diseases including necrosis, fibrosis and cholestasis; the role of cytokines in liver diseases; and oxidative stress and its relation to liver disease. He has published over 100 articles (original and reviews) in addition to 7 book chapters in the area of the liver and has also directed the thesis on dozens of postgraduate students in the same area over the last 30 years. The majority of his work has been in the Medicine and Pharmacology areas. He shows strong and growing citation counts from 2010-2017.
Affiliations and Expertise
Researcher and Professor, Cinvestav-IPN, Mexico City, Mexico