Heparin: Structure, Cellular Functions, and Clinical Applications - 1st Edition - ISBN: 9780124848504, 9780323151627

Heparin: Structure, Cellular Functions, and Clinical Applications

1st Edition

Editors: Norman Mcduffie
eBook ISBN: 9780323151627
Imprint: Academic Press
Published Date: 1st January 1979
Page Count: 410
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Heparin: Structure, Cellular Functions, and Clinical Applications compiles lectures presented at the International Symposium on Heparin held at Saskatoon on July 6-8, 1977. Heparin has been the leader in antithrombotic therapy ever since its introduction several years ago. This substance initiated a field of therapeutics and made possible dramatic advances in cardiac surgery, vascular surgery, acute and chronic hemodialysis, and a variety of other medical and surgical procedures. This book discusses several concepts pertaining to the heparin molecule, its pharmacology, physiology, and clinical application. Other topics covered include the use of heparin in preventing thrombosis; use of pharmacodynamic studies for establishing dosage; identification of differences in heparins among various mammalian species; and methods for the determination of heparin. The demonstration of the platelet aggregating effect of commercial heparin preparations; heparin's reaction with toluidine blue; identification of iduronic acid as a major component of heparin; and identification of circulating heparin in canine anaphylaxis are discussed as well. This compilation is a good reference for students and individuals conducting research on heparin and its physiological role.

Table of Contents

Contributors and Participants Foreword Preface Structure Enzymatic Degradation of Heparin as a Tool for Structural Analysis Recent Structural Studies on Heparin Structure of Sulfated Mucopolysaccharides from Normal Tissues and from Patients with Mucopolysaccharidoses The Metabolism of Macromolecular Heparin Heparin from Rat Peritoneal Mast Cells Structural Characteristics of Heparins Revealed by Electrofocusing A Contribution to the Problem of Heparin Discussion Structure and Pharmacodynamics Some Structure-Function Relationships of Heparins and Their Component Fractions Heparin: Physical and Biological Factors in Absorption Structural Basis for the Biological Effects of Heparin Evidence for a Cellular Pool for Exogenous Heparin Heparin and Factor VIII Fundamental Relations of Heparin to Fibrinogen and to Other Living Proteins Discussion Cellular Function Heparan Sulfate: Functional Role at the Cellular Level Heparan Sulfate and Related Complex Carbohydrates of Nervous Tissue The Role of the Heparin Protein Complex in the Storage of Histamine in Mast Cells Do Mast Cells Secrete Their Granules? Heparin and Endothelium Hypothesis on the Pharmacological Action of Subcutaneous "Low-Dose" or "Small-Dose" Heparin Discussion Clinical Application Heparin Therapy in Venous Thrombosis and Pulmonary Embolism: Clinical and Experimental Observations Heparin by Inhalation Clinical Use of Heparin and Heparinoids, Excluding the Treatment of Thromboembolism Discussion Concluding Remarks 40 Years of Heparin Research-Past and Future Index


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© Academic Press 1979
Academic Press
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About the Editor

Norman Mcduffie

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