Heparin: Structure, Cellular Functions, and Clinical Applications

Heparin: Structure, Cellular Functions, and Clinical Applications

1st Edition - January 1, 1979

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  • Editor: Norman Mcduffie
  • eBook ISBN: 9780323151627

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Description

Heparin: Structure, Cellular Functions, and Clinical Applications compiles lectures presented at the International Symposium on Heparin held at Saskatoon on July 6-8, 1977. Heparin has been the leader in antithrombotic therapy ever since its introduction several years ago. This substance initiated a field of therapeutics and made possible dramatic advances in cardiac surgery, vascular surgery, acute and chronic hemodialysis, and a variety of other medical and surgical procedures. This book discusses several concepts pertaining to the heparin molecule, its pharmacology, physiology, and clinical application. Other topics covered include the use of heparin in preventing thrombosis; use of pharmacodynamic studies for establishing dosage; identification of differences in heparins among various mammalian species; and methods for the determination of heparin. The demonstration of the platelet aggregating effect of commercial heparin preparations; heparin's reaction with toluidine blue; identification of iduronic acid as a major component of heparin; and identification of circulating heparin in canine anaphylaxis are discussed as well. This compilation is a good reference for students and individuals conducting research on heparin and its physiological role.

Table of Contents


  • Contributors and Participants

    Foreword

    Preface

    Structure

    Enzymatic Degradation of Heparin as a Tool for Structural Analysis

    Recent Structural Studies on Heparin

    Structure of Sulfated Mucopolysaccharides from Normal Tissues and from Patients with Mucopolysaccharidoses

    The Metabolism of Macromolecular Heparin

    Heparin from Rat Peritoneal Mast Cells

    Structural Characteristics of Heparins Revealed by Electrofocusing

    A Contribution to the Problem of Heparin

    Discussion

    Structure and Pharmacodynamics

    Some Structure-Function Relationships of Heparins and Their Component Fractions

    Heparin: Physical and Biological Factors in Absorption

    Structural Basis for the Biological Effects of Heparin

    Evidence for a Cellular Pool for Exogenous Heparin

    Heparin and Factor VIII

    Fundamental Relations of Heparin to Fibrinogen and to Other Living Proteins

    Discussion

    Cellular Function

    Heparan Sulfate: Functional Role at the Cellular Level

    Heparan Sulfate and Related Complex Carbohydrates of Nervous Tissue

    The Role of the Heparin Protein Complex in the Storage of Histamine in Mast Cells

    Do Mast Cells Secrete Their Granules?

    Heparin and Endothelium

    Hypothesis on the Pharmacological Action of Subcutaneous "Low-Dose" or "Small-Dose" Heparin

    Discussion

    Clinical Application

    Heparin Therapy in Venous Thrombosis and Pulmonary Embolism: Clinical and Experimental Observations

    Heparin by Inhalation

    Clinical Use of Heparin and Heparinoids, Excluding the Treatment of Thromboembolism

    Discussion

    Concluding Remarks

    40 Years of Heparin Research-Past and Future

    Index

Product details

  • No. of pages: 410
  • Language: English
  • Copyright: © Academic Press 1979
  • Published: January 1, 1979
  • Imprint: Academic Press
  • eBook ISBN: 9780323151627

About the Editor

Norman Mcduffie

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