Henry's Clinical Diagnosis and Management by Laboratory Methods

Henry's Clinical Diagnosis and Management by Laboratory Methods

24th Edition - June 1, 2021

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  • Authors: Richard McPherson, Matthew Pincus
  • eBook ISBN: 9780323755085
  • Hardcover ISBN: 9780323673204

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Description

For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout.

Table of Contents

  • Instructions for online access
  • Cover image
  • Title page
  • Table of Contents
  • Associate Editors
  • Copyright
  • Contributors
  • Preface
  • Acknowledgments
  • Part 1. The Clinical Laboratory
  • Chapter 1. General Concepts and Administrative Issues
  • Strategic Planning
  • Quality Systems Management
  • Human Resource Management
  • Financial Management
  • Laboratory Design and Service Models
  • Regulation, Accreditation, and Legislation
  • Safety
  • Chapter 2. Optimizing Laboratory Workflow and Performance
  • Understanding Workflow
  • Understanding Technology
  • Optimizing Performance
  • Chapter 3. Preanalysis
  • Precollection Variables
  • Specimen Collection
  • Blood Collection Overview
  • Blood Collection Techniques
  • Urine And Other Body Fluids Collection
  • Specimen Transport
  • Specimen Processing
  • Chapter 4. Analysis: Principles Of Instrumentation
  • Principles Of Instrumentation
  • General Analytic Methods And Issues
  • Chapter 5. Mass Spectrometry and Applications
  • Overview
  • Definitions And Terminology
  • Principles of Mass Spectrometry
  • Analytic Methods
  • Mass Spectrometry in a Clinical Environment
  • Ms-Based Omics
  • Challenges in Implementing Mass Spectrometry into Clinical Laboratories
  • Future Perspectives on Clinical Mass Spectrometry
  • Chapter 6. Analysis: Clinical Laboratory Automation
  • Evolution Of Automation
  • Preanalytic And Postanalytic Automation
  • The Automated Chemistry Analyzer: Core Components
  • The Continuum Of Chemistry Automation
  • Automation In Other Sections Of The Laboratory
  • Planning For Laboratory Automation
  • Chapter 7. Point-Of-Care Testing And Physician Office Laboratories
  • Introduction: Definition Of Point-Of-Care Testing
  • Regulatory Requirements
  • Laboratory Directorship
  • Compliance
  • Types Of Point-Of-Care Testing
  • Advantages And Disadvantages Of Point-Of-Care Testing
  • Connectivity And Data Management
  • Implementation Of A Point-Of-Care Testing Program
  • Maintenance Of A Point-Of-Care Testing Program
  • Conclusions
  • Chapter 8. Postanalysis: Medical Decision Making
  • Assessment of Analytic Correctness of Results
  • Assessment of Clinical Significance of Results
  • General Principles for the Interpretation of Laboratory Results
  • Evidence-Based Medicine
  • Systematic Reviews of Clinical Effectiveness Research and Clinical Practice Guidelines
  • Chapter 9. Interpreting Laboratory Results
  • Interpreting and Correlating Abnormal Laboratory Values
  • Abnormalities in the Hematology Profile
  • Abnormalities in Clinical Chemistry: Chemical Pathology
  • Examples of Clinical Cases with Clinicopathologic Correlations
  • Chapter 10. Laboratory Statistics
  • Definitions
  • Variables
  • Preparing to Analyze Data
  • Descriptive Statistics
  • Comparative Statistics
  • Analyzing Discrete Data: Testing Proportions
  • Trend Evaluation and Correlative Statistics
  • Method Validation and Process Control
  • Resources for Statistical Analysis
  • Chapter 11. Quality Control
  • Analytic Bias and Imprecision
  • Calibration Considerations in Quality Control
  • Overview of Quality Control Procedures
  • Implementing Quality Control Procedures
  • Verifying Quality Control Evaluation Parameters Following a Reagent Lot Change
  • Verifying Method Performance Following Use of a New Lot of Calibrator
  • Using Patient Data in Quality Control Procedures
  • Proficiency Testing
  • Quality Management
  • 12. Clinical Laboratory Informatics
  • Fundamentals of Clinical Informatics
  • Database Fundamentals: Design, Implementation, and Maintenance
  • Positive Patient and Specimen Identification and Barcoding
  • Laboratory Information Systems
  • Artificial Intelligence and Machine Learning
  • Glossary
  • Chapter 13. Financial Management
  • Industry Overview
  • Defining and Identifying Costs
  • Revenue
  • Payers and Reimbursement
  • Reimbursement Coding Systems
  • Financial Performance and Monitoring
  • Evaluating A Capital Project
  • Capital Acquisition Methods
  • Chapter 14. Ethics In Laboratory Medicine
  • Hippocratic Oath Today
  • Regulations
  • Human Subject Research
  • Development Of Federal Regulations For Human Subjects Research
  • Case Reports
  • Categories Of Human Subjects Research
  • Method validation or newly developed assays—trials for u.s. Food and drug administration submission
  • Close Out Of A Research Study
  • Research In The Clinical Laboratory
  • Confidentiality Of Genetic Information
  • Clinical Trial Phases
  • Authorship
  • Dishonest Behavior
  • Kickbacks/Bribery
  • Ownership Of Specimens
  • Summary
  • Part 2. Clinical Chemistry
  • Chapter 15. Evaluation Of Renal Function, Water, Electrolytes, And Acid-Base Balance
  • Introduction
  • Volumes And Osmolality Of Body Fluid
  • Regulation Of Extracellular Volume
  • Measurement Of Renal Function
  • Biomarkers Of Acute Kidney Injury (AKI)
  • Disorders Of Potassium
  • Disorders Of Water, Sodium, And Antidiuretic Hormone (ADH) Metabolism
  • Acid-Base Disorders
  • Chapter 16. Biochemical Markers Of Bone Metabolism
  • Mineral And Bone Metabolism
  • Disorders Of Mineral Metabolism
  • Biochemical Markers Of Bone Remodeling
  • Metabolic Bone Disease
  • Chapter 17. Carbohydrates
  • Function of the Endocrine Pancreas
  • Glucose Measurements
  • Diabetes Mellitus
  • Hypoglycemia
  • Inborn Errors of Carbohydrate Metabolism
  • CHAPTER 18. Lipids And Dyslipoproteinemia
  • Overview
  • Lipoproteins, Apolipoproteins, And Related Proteins
  • Lipid Transport and Lipoprotein Metabolism
  • Lipid and Lipoprotein Measurement
  • Additional Methods in The Study Of Dyslipidemia
  • Guidelines for cholesterol testing and management
  • Lipids, Lipoproteins, and Disease
  • High triglyceride and low HDL cholesterol
  • Chapter 19. Cardiac Injury, Atherosclerosis, And Thrombotic Disease
  • Overview
  • Background
  • Markers Of Myocardial Damage
  • Clinical protocols
  • Markers of congestive heart failure
  • Other Conditions Associated With Atherosclerosis or Thrombosis
  • Chapter 20. Specific Proteins
  • Protein Structure
  • Techniques Of Protein Separation
  • Protein Detection And Quantitation
  • Specific Plasma Proteins
  • Patterns Of Protein Abnormalities
  • Chapter 21. Clinical Enzymology
  • General Properties of Enzymes
  • Enzyme Kinetics: Determination Of Total Enzyme Concentrations In Serum And Other Body Fluids
  • Inhibition of Enzymes
  • Catalytic Efficiency: Transition State Theory And Drug Design
  • Specific Enzymes
  • Chapter 22. Evaluation Of Liver Function
  • Normal Liver Function
  • Tests Of Liver Injury
  • Diagnosis Of Liver Diseases
  • Chapter 23. Laboratory Diagnosis of Gastrointestinal and Pancreatic Disorders
  • Pancreatic Disorders
  • Gastroenterologic Disorders
  • Stool Collection and Examination
  • Chapter 24. Toxicology and Therapeutic Drug Monitoring
  • Basic Techniques for Detecting Drugs in Serum and Urine
  • The Drugs of Abuse
  • Therapeutic Drug Monitoring
  • Toxins and Acute Poisoning
  • Conclusion
  • Chapter 25. Evaluation of Endocrine Function
  • Pituitary Function
  • Thyroid Function
  • Adrenal Function
  • Renin-Aldosterone Axis
  • Chapter 26. Reproductive Function and Pregnancy
  • Normal Physiology
  • Laboratory Evaluation of Reproductive Function
  • Laboratory Evaluation of Pregnancy
  • Chapter 27. Vitamins and Trace Elements
  • Introduction
  • Vitamins
  • Trace Elements
  • Chapter 28. Chemical Basis for Analyte Assays and Common Interferences
  • Introduction
  • Ion-Selective Electrodes
  • Spectrophotometric Determinations Using Simple Reagents
  • Use of Enzymes as Reagents to Determine Analyte Concentrations
  • Part 3. Urine and Other Body Fluids
  • Chapter 29. Basic Examination of Urine
  • Urine Formation
  • Components of Basic (Routine) Urinalysis
  • Methods For Urinalysis
  • Special Testing And Monitoring Techniques
  • Chapter 30. Cerebrospinal, Synovial, Serous Body Fluids, and Alternative Specimens
  • Cerebrospinal Fluid
  • Synovial Fluid
  • Pleural Fluid
  • Pericardial Fluid
  • Peritoneal Fluid
  • Alternative Specimens
  • Chemical Measurements in Body Fluids
  • Part 4. Hematology and Transfusion Medicine
  • Chapter 31. Basic Examination of Blood and Bone Marrow
  • Hematology Principles and Procedures
  • Blood Film Examination
  • Bone Marrow Examination
  • Chapter 32. Hematopoiesis
  • Stem Cells
  • Hematopoietic Tissues
  • Erythrocyte Production
  • Erythrocyte Destruction
  • Erythrokinetics
  • Neutrophils
  • Eosinophils
  • Basophils And Mast Cells
  • Monocytes And Macrophages
  • Megakaryocytes
  • Lymphocytes
  • Chapter 33. Erythrocytic Disorders
  • Anemias
  • Polycythemia
  • The porphyrias
  • Chapter 34. Leukocytic Disorders
  • Leukocytes
  • Nonneoplastic Disorders
  • Neoplastic Disorders Primarily Involving Leukocytes
  • Chapter 35. The Flow Cytometric Evaluation of Hematopoietic Neoplasia
  • Technical Considerations
  • Interpretive Considerations
  • Summary
  • Chapter 36. Immunohematology
  • Basic Immunohematologic Concepts
  • Erythrocyte Antigens and Antibodies
  • Immunohematology Tests And Procedures
  • Positive Direct Antiglobulin Tests and Hemolytic Anemia Induced By Medication
  • Granulocyte serology
  • Platelet serology
  • Chapter 37. Transfusion Medicine
  • Background
  • Blood Collection
  • Blood Component Manufacture
  • Selection of Blood Components
  • Pretransfusion Testing
  • Transfusion Administration
  • Transfusion Reactions
  • Conclusion
  • Chapter 38. Hemapheresis
  • Introduction
  • Donor Cytapheresis
  • Donor Plasmapheresis
  • Indications for Therapeutic Hemapheresis
  • Donor/Patient Complications Common to All Hemapheresis Procedures
  • Summary
  • Chapter 39. Tissue Banking and Progenitor Cells
  • Sources of Tissue
  • Tissue Bank Activities
  • Skin Banking
  • Musculoskeletal Tissues
  • Cardiac Valves
  • Cornea
  • Reproductive Tissue
  • Hematopoietic Progenitor Cell Banking
  • Part 5. Hemostasis and Thrombosis
  • Chapter 40. Coagulation And Fibrinolysis
  • Overview Of Hemostasis
  • Physiologic Hemostasis
  • Clinical Hemostasis
  • Hereditary Coagulation Protein Defects
  • Acquired Coagulation Disorders
  • Chapter 41. Platelet Disorders and Von Willebrand Disease
  • Normal Platelet Biology
  • Laboratory Evaluation of Platelet Disorders
  • Quantitative Platelet Disorders
  • Inherited Disorders of Platelet Function
  • Acquired Disorders of Platelet Function
  • Von Willebrand Factor, Von Willebrand Disease, and Thrombotic Thrombocytopenic Purpura
  • Chapter 42. Laboratory Approach to Thrombotic Risk
  • Endogenous Anticoagulant Mechanisms
  • Prothrombotic States
  • Appropriate Laboratory Utilization
  • Chapter 43. Antithrombotic Therapy
  • Vitamin K Antagonists
  • Antithrombin-Dependent Parenteral Anticoagulants
  • Target-Specific Anticoagulants
  • Antiplatelet Therapy
  • Part 6. Immunology and Immunopathology
  • Chapter 44. Overview of the Immune System and Immunologic Disorders
  • Lymphoid Cells
  • Nonlymphoid Cells
  • Humoral Factors
  • Histocompatibility Antigens
  • Mechanisms of Immunologic Injury
  • Laboratory Applications of Immunologic Assessment
  • Therapeutics in Immunology
  • Chapter 45. Immunoassays And Immunochemistry
  • Immunoassays And Immunochemistry
  • Overview Of General Principles Of Immunoassays
  • Precipitin And Nephelometric Immunoassays
  • Particle Immunoassay
  • Radioimmunoassay
  • Enzyme Immunoassay
  • Fluorescent Immunoassay
  • Chemiluminescent Immunoassay
  • Instrument Automation And Modulation Of Assay Systems
  • Rapid And Simple Test Devices For Point-Of-Care Testing
  • Noncompetitive Immunoassay For Small Molecules
  • Sensitive Immunoassay For Total Antigen Including Complex Using Specimen-Pretreatment Method
  • Simultaneous Multiple Immunoassays
  • Single-Molecule Detection
  • Chapter 46. Laboratory Evaluation of The Cellular Immune System
  • General Principles of Cellular Immunology
  • Flow and Image Cytometry In Evaluation Of Cellular Immunity
  • Gating and Data Analysis
  • Clinical Significance of Cellular Immune Testing
  • Clinical Interpretation of Cellular Immune Testing
  • Methodologic Approach to Cellular Immune Testing
  • Laboratory Evaluation of Lymphocyte Function
  • Laboratory Evaluation of Granulocyte And Monocyte Function
  • Quality Control and Quality Assurance in the Cellular Laboratory
  • Chapter 47. Laboratory Evaluation Of Immunoglobulin Function And Humoral Immunity
  • Structural Properties Of Antibodies
  • The Genetic Basis Of Antibody Diversity
  • General Properties Of Immunoglobulins
  • Clinical Significance Of Immunoglobulins
  • Chapter 48. Mediators of Inflammation: Complement
  • Structure and Function of The Complement System
  • Genetic Complement Deficiencies
  • Assessment Of Complement Activity In Disease
  • Complement In Disease States
  • Clinically Useful Complement Inhibitors
  • Assays Of Complement
  • Kinins And The Kinin-Generating System
  • Perspectives
  • Chapter 49. Mediators of Inflammation: Cytokines and Adhesion Molecules
  • Cytokines
  • Chemokine And Chemokine Receptor Family
  • Cell Adhesion Molecules
  • Leukocyte Extravasation
  • Perspectives
  • Chapter 50. Human Leukocyte Antigen: The Major Histocompatibility Complex of Humans
  • Introduction
  • Genetics of The Major Histocompatibility Complex
  • Class I Molecules—HLA-A, HLA-B, and HLA-C Subregions
  • Class II Molecules—HLA-DR, HLA-DQ, and HLA-DP Subregions
  • Characteristics of Antigenic Fragments Bound By MHC Class I and Class II Molecules
  • Recognition of Foreign MHC Molecules
  • Minor Histocompatibility Molecules
  • HLA Nomenclature
  • Techniques for Identifying HLA Polymorphism
  • Tissue/Organ Transplantation
  • Summary
  • Chapter 51. The Major Histocompatibility Complex And Disease
  • Overview Of The Human Major Histocompatibility Complex Dna Sequence
  • Genes In The Central Or Class Iii Region
  • Extended Haplotypes
  • Mhc Disease Associations
  • Methods Of Detecting Association Or Linkage Of Disease With Genetic Markers
  • Summary
  • Chapter 52. Immunodeficiency Disorders
  • Diagnostic Considerations in Immunodeficiency Workups
  • Evaluation of the Immune System
  • Novel Approaches to Treating Immunodeficiency Disorders
  • Summary
  • Chapter 53. Clinical and Laboratory Evaluation of Systemic Autoimmune Rheumatic Diseases
  • Introduction and Classification of Systemic Autoimmune Rheumatic Diseases
  • Systemic Lupus Erythematosus and Related Lupus–Like Disorders
  • Sjögren Syndrome
  • Systemic Sclerosis
  • Rheumatoid Arthritis
  • Idiopathic Inflammatory Myopathies
  • Concept of Overlap Syndromes
  • Profiles of Autoantibodies in Various Systemic Rheumatic Diseases
  • Techniques Used To Detect Autoantibodies
  • Chapter 54. Vasculitis
  • Introduction
  • Diagnostic Classification Of Vasculitis
  • Large Vessel Vasculitis
  • Medium Vessel Vasculitis
  • Small Vessel Vasculitis
  • Summary
  • Chapter 55. Organ-Specific Autoimmune Diseases
  • Introduction and Overview to the Organ-Specific Autoimmune Diseases
  • Cutaneous Autoimmune Diseases
  • Gastrointestinal and Hepatobiliary Autoimmune Diseases
  • Glomerular Autoimmune Diseases
  • Immunoendocrinopathies
  • Autoimmune Diseases of the Neuromuscular Junction, Nervous System, and Muscle
  • Conclusion
  • Chapter 56. Allergic Diseases
  • Overview
  • Pathogenesis of Allergic Disease
  • Laboratory Testing in the Evaluation of Allergic Diseases
  • Part 7. Medical Microbiology
  • Chapter 57. Medical Bacteriology
  • Specimen Processing
  • Medically Important Bacteria
  • Chapter 58. In Vitro Testing of Antimicrobial Agents
  • Introduction and Definitions
  • Technical Considerations in Susceptibility Testing
  • Inhibitory Methods for Susceptibility Testing
  • Bactericidal Testing
  • Commercial Automated Instrument Systems
  • Molecular-Based and Newer Methods of Antimicrobial Susceptibility Testing
  • Indications for Susceptibility Testing
  • Selection of Antibiotics for Testing
  • Selecting Antibiotics to Be Reported
  • Cumulative Antimicrobial Susceptibility Reports
  • Chapter 59. Mycobacteria
  • Mycobacterium Tuberculosis Complex
  • Nontuberculous Mycobacteria
  • Testing for latent M. Tuberculosis infection
  • Laboratory Diagnosis
  • Treatment
  • Prevention
  • Chapter 60. Mycotic Diseases
  • Nomenclature, Taxonomy, and Fungal Morphology
  • Diagnostic Techniques
  • Candidiasis, Cryptococcosis, and Other Infections Caused by Yeast
  • Mycoses Caused by Dimorphic Fungi
  • Dermatophytoses
  • Mycoses Caused by Dematiaceous (Melanized) Fungi
  • Mucormycosis (Zygomycosis)
  • Aspergillosis, Fusariosis, and Other Mycoses Caused by Hyaline Fungi
  • Microsporidiosis
  • Pneumocystis Pneumonia
  • Protothecosis
  • Chapter 61. Spirochete Infections
  • Treponema
  • Leptospira
  • Borrelia
  • Agents of Intestinal Spirochetosis
  • Chapter 62. Chlamydial And Mycoplasmal Infections
  • Chlamydial Infections
  • Mycoplasmal and Ureaplasmal Infections
  • Chapter 63. Rickettsiae and Other Related Intracellular Bacteria
  • Rickettsial Infections
  • Chapter 64. Viral Infections
  • Introduction
  • Clinical Viral Infectious Syndromes
  • Summary
  • Chapter 65. Medical Parasitology
  • Parasite Classification and Taxonomy
  • Laboratory Methods
  • Blood and Tissue Protozoa
  • Intestinal Helminths
  • Tissue Helminths
  • Medically Important Arthropods
  • Parasitic Infections and the Immunocompromised Host
  • Chapter 66. Specimen Collection and Handling for Diagnosis of Infectious Diseases
  • General Principles
  • Blood
  • Body Fluids
  • Tissues
  • Eye
  • Respiratory Tract
  • Urinary Tract
  • Genital Tract
  • Feces
  • Skin and Subcutaneous Lesions
  • Part 8. Molecular Pathology
  • 67. Introduction To Molecular Pathology
  • Introduction
  • Special Considerations For Molecular Diagnostics Laboratories
  • The Molecular Biology Revolution And Its Impact On The Practice Of Pathology
  • Discussion Of Diagnostic Molecular Pathology
  • Implications Of Molecular Diagnostics On The Practice Of Pathology And Medicine
  • Quality Assurance
  • Financial Management Reimbursement For Molecular Diagnostics Tests
  • Some Caveats
  • Chapter 68. Molecular Diagnostics: Basic Principles And Techniques
  • Nucleic Acid Biochemistry And Biology
  • Nucleic Acid Analyses
  • Relationship To Laboratory Evaluation Of Disease
  • Chapter 69. Polymerase Chain Reaction And Other Nucleic Acid Amplification Technology
  • Target Amplification Methods
  • Probe And Signal Amplification Methods
  • Summary
  • Chapter 70. Hybridization Array Technologies
  • Array Technologies
  • Clinical Applications of Array Technology
  • 71. Applications of Cytogenetics in Modern Pathology
  • Definitions
  • Cytogenetics
  • Clinical Applications
  • Summary
  • 72. Molecular Diagnosis of Genetic Diseases
  • Introduction
  • Choice of Techniques
  • Choice of Applications
  • Special Concepts Unique To Molecular Genetic Disorders
  • Specific Disease Examples
  • The New Frontier of Diagnostic Molecular Genetics: Genome-Level Dna Sequencing
  • Chapter 73. Molecular Genetics of Neuropsychiatric Disorders: Current Research and Perspectives
  • Introduction
  • Genome-Wide Association Studies
  • Neuropsychiatric Diseases
  • Future Directions and Concluding Remarks
  • Chapter 74. Identity Testing: Use of Dna Analysis In Parentage, Forensic, And Missing Persons Testing
  • Historical Background
  • Advantages of Dna
  • Samples and Specimen Collection
  • Dna Extraction And Quantification
  • Genetic Marker Systems and Test Methods
  • Software Systems
  • Use of Test Data
  • Exclusion of Parentage
  • Inclusion of Parentage
  • Quality Assurance Standards
  • Conclusion
  • Chapter 75. Pharmacogenomics and Personalized Medicine
  • Overview
  • Basic Concepts
  • Drug-Metabolizing Enzyme Pharmacogenomics
  • Drug-Transporter Pharmacogenomics
  • Drug Target Pharmacogenomics
  • Human Leukocyte Antigen Pharmacogenomics
  • Pharmacogenomics In Cancer Chemotherapy
  • Pharmacogenomics in Other Diseases
  • Conclusion
  • Part 9. Clinical Pathology of Cancer
  • Chapter 76. Diagnosis and Management of Cancer Using Serologic and Other Body Fluid Markers
  • Serum Markers as an Effective Tool For Diagnosis and Monitoring Of Cancer
  • Functional Classification of Tumor Markers
  • Clinical Applications
  • Recommendations for Ordering Tumor Marker Tests
  • Individual Tumor Markers
  • Circulating Tumor Cells in Peripheral Blood
  • Circulating Nucleic Acids in Peripheral Blood
  • Markers in Other Body Fluids
  • Conclusions
  • Chapter 77. Oncoproteins And Early Tumor Detection
  • Overview
  • Oncoproteins In Tumor Detection
  • Use Of Multiple Protein Markers In The Diagnosis Of Cancer: Proteomics
  • Evaluation And Conclusions
  • Chapter 78. Molecular Diagnosis of Hematopoietic Neoplasms
  • Molecular Diagnosis of Lymphoid Neoplasms
  • Molecular Diagnosis of Myeloid Neoplasms
  • Chapter 79. Molecular Genetic Pathology Of Solid Tumors
  • Molecular Genetic Pathology of Specific Solid Tumors By Major Organ
  • Molecular Genetic Pathology of Sarcoma
  • Molecular Genetic Pathology of Multiple Endocrine Neoplasia
  • Cancers of Unknown Origin
  • Clinical Application of Next-Generation Sequencing
  • 80. High-Throughput Genomic and Proteomic Technologies in the Postgenomic Era
  • Overview
  • The Human Genome Project
  • High-Throughput Technologies
  • Molecular Markers For The Diagnosis Of Human Neoplasia
  • Diagnostic Cancer Applications
  • Prognostic Molecular Markers Of Disease
  • Pitfalls of Molecular Markers for both Prognostics and Diagnostics
  • Emerging Technologies
  • Conclusion and Future Challenges
  • Appendix 1. Physiologic Solutions, Buffers, Acid-Base Indicators, Standard Reference Materials, and Temperature Conversions
  • Appendix 2. Desirable Weights, Body Surface Area, and Body Mass Index
  • Appendix 3. Approximations of Total Blood Volume
  • Appendix 4. Periodic Table of the Elements
  • Appendix 5. SI Units
  • Appendix 6. Common Chimeric Genes Identified in Human Malignancies
  • Appendix 7. Disease/Organ Panels
  • Index
  • Guidelines for Ordering Blood for Elective Surgery

Product details

  • No. of pages: 1618
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: June 1, 2021
  • Imprint: Elsevier
  • eBook ISBN: 9780323755085
  • Hardcover ISBN: 9780323673204

About the Authors

Richard McPherson

Affiliations and Expertise

Professor of Pathology, Emeritus, Virginia Commonwealth University, Richmond, Virginia

Matthew Pincus

Affiliations and Expertise

Professor, Department of Pathology, State University of New York Downstate Medical Center, Brooklyn, New York; Chief, Department of Pathology and Laboratory Medicine, New York Harbor VA Medical Center, New York, New York

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