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Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis.
- Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles
- Combines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncology
- Delves into unanswered questions and future directions of this important blood-clotting complex
Residents, fellows and professionals in hematology, genetics, cell biology, oncology, and drug discovery
1. Historical Background
2. Factor VIII: Anatomy and Physiology
A. Isolation & Relationship to the Von Willebrand Factor
C. Cell of Origin, Secretion, & Clearance
D. Participation in Hemostasis & Inactivation
3. Genetic Basis of Hemophilia
A. Factor VIII gene
C. Hemophilia in Women
D. Carrier Detection & Prenatal Diagnosis
4. Factor VIII Therapy for Bleeding
A. Plasma and Cryoprecipitate
B. Recombinant Factor VIII
C. Gene Therapy
5. Complications of Therapy
A. Allergic Reactions
6. Acquired Disorders of Factor VIII
7. Factor VIII and Thrombosis
A. Genetic disorders
C. Role in Thrombosis
D. Antithrombotic Therapy
8. Factor VIII: Future Directions
A. Re-engineering FVIII for oral or topical administration
B. Decreasing FVIII immunogenicity
C. Anti-thrombotics that block FVIII
D. Genetic and cell-based approaches
- No. of pages:
- © Academic Press 2018
- 14th June 2018
- Academic Press
- eBook ISBN:
- Paperback ISBN:
David Green, MD, PhD, is Professor Emeritus in Medicine, Division of Hematology/Oncology, at Northwestern University Feinberg School of Medicine in Chicago, Illinois. He received his medical degree from Jefferson Medical College in Philadelphia, Pennsylvania and Doctorate in Biochemistry from Northwestern University, Evanston, Illinois. He is a clinician-investigator and author of more than 300 published scientific articles. His most recent book, Linked by Blood: Hemophilia and AIDS, describes the AIDS epidemic in the early 1980s that ravaged the hemophilia community and led to major changes in the collection and processing of blood and blood products. He is a Master of American College of Physicians and recipient of many other awards.
Professor of Medicine Emeritus, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
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