Hematopoietic Stem Cell Niche

Chapter One: Stroma Cell Niche Regulation During HSC Development

• Abstract
• 1 Introduction
• 2 The AGM Hematopoietic Microenvironment
• 3 The FL and Placenta Hematopoietic Microenvironments
• 4 Extracting the Molecular Core of the HSPC Niche
• 5 Conclusion
• Acknowledgments

Chapter Two: The Evolvement of Hematopoietic Stem Cell Niches

• Abstract
• 1 The Origin of HSC Niche Concept
• 2 Relocation of HSCs During Development
• 3 The Identification of HSC Niches
• 4 BM Niches for HSC Regeneration
• 5 HSC Niches Beyond BM
• 6 Mature Hematopoietic Cells as HSC Niche
• 7 Perspective

Chapter Three: The Role of the CNS in the Regulation of HSCs

• Abstract
• 1 The Autonomic Nervous System
• 2 Neural Contributions to Hematopoiesis: Multiple and From Development
• 3 Parasympathetic Innervation of Lymphoid Organs
• 4 Sympathetic Innervation of Lymphoid Organs
• 5 Toward Functionally Defining the Adrenergic Regulation of Hematopoiesis
• 6 Day–Night Oscillations of Hematopoiesis
• 7 Sympathetic Signaling in Hematological Malignancies
• 8 Sensory Innervation of Lymphoid Organs
• 9 Conclusions and Futures Perspectives
• Acknowledgments

Chapter Four: Imaging the Hematopoietic Stem Cell Niche

• Abstract
• 1 Introduction
• 2 Experimental Models Allowing Visualization of HSCs
• 3 Experimental Models Allowing Visualization of BM Niches
• 4 Optical Microscopy Approaches
• 5 Imaging HSC Niches: From 2D to 3D Samples
• 6 Intravital Microscopy
• 7 Emerging Approaches in IVM
• 8 Imaging Human HSCs
• 9 Imaging HSC Niches in Other Model Organisms
• 10 Conclusion
• Acknowledgments

Chapter Five: Mechanisms of Hematopoietic Stem and Progenitor Cells Bone Marrow Homing and Mobilization

• Abstract
• 1 Introduction
• 2 Getting HSPC in the BM Niche (HSPC Homing)
• 3 Getting HSPC Out of the BM Niche (HSPC Mobilization)
• 4 Summary and Concluding Remarks

Chapter Six: Alterations of HSC Niche in Myeloid Malignancies

• Abstract
• 1 Location and Cellular Components of Normal Stem Cell Niche
• 2 Stem Cell Niche Alteration in Myeloid Disorders
• 3 Future Perspectives

Chapter Seven: Targeting the Bone Marrow Niche in Hematological Malignancies

• Abstract
• 1 Introduction
• 2 Targeting the BMM for the Treatment of Hematological Malignancies
• 3 Conclusions